Conveners
Poster Session
- Magdalena Skurzok (Jagiellonian University)
- Szymon Niedźwiecki (Jagiellonian University)
Spheroids are a model commonly used in research into new cancer treatments and therapies. They mimic the structure, microenvironment and cells signaling present in solid tumors [1]. The following features can be recalled, that makes spheroids a perfect model for investigations into cancer treatment, like their layered composition, forced by the availability of nutrients, the growth kinetics...
Detectors play a fundamental role in understanding physical phenomena and improved our understanding. The rapid development in this area of science has been increased interest to enhance the performance of detectors to achieve precise results. Photomultiplier tube (PMT) known as one of the main parts of the detectors which are constructed in the shape of a vacuum tube and can detect light...
Molecular PET / CT imaging is used for the diagnosis of patients with neuroendocrine tumors with the use of radiolabelled somatostatin analogues. Iterative image reconstruction techniques are used to obtain the image.Unfortunately, as a result of the significant impact of the so-called "Partial Volume Effect" in minor changes in pathological radiopharmaceutical uptake, the results of the...
carina.rzaca@doctoral.uj.edu.pl
Nowadays extracellular vesicles (EVs) are being actively researched. EVs are involved with several biological processes including cell signalling, transfer specific cargo (lipids, proteins, and nucleic acids) and biomarkers of disease. EVs can be divided according to their size and way of arising into exosomes (diameter from 30 nm to 100 nm) and ectosomes...
Human albumin (HSA) is the main plasma protein that ensures the maintenance of proper osmotic blood pressure and is also involved in the transport of metabolites to cells. It exhibits high solubility at pH = 7.4 and the ability to bind molecules, making it possible to use it as a transporter of drugs such as 5-fluorouracil (5-FU). 5-FU is a drug that causes the incorporation of...
Being able to predict whether a sample is contaminated with any toxic substances or not is crucial, especially when it comes to health, and this is where machine learning algorithms are essential [1-2]. In our research the emphasis was put on the ability to classify samples contaminated with two types of heavy metals: zinc (Zn), cadmium (Cd), and the mixture of these two elements (Zn+Cd),...
The small size of ectosomes makes their isolation and obtaining the appropriate protein yield for liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analyzes a considerable methodological challenge. Especially isolation of ectosomes from limited amount of body fluids of cancer patients means that a much smaller amount of protein is available for LC-MS/MS. The SP3...
Paweł Konieczka, on behalf of the J-PET collaboration
Convolutional Neural Networks are excellent at analyzing images by
learning abstract representations. CNN has been an overwhelming strategy
in computer vision tasks and has achieved expert-level performances in
various fields. There has been a surge of interest in the potential of
CNN among radiology researchers and several studies...
Discrete symmetry under the combined transformation of charge, parity, and time reversal (CPT) can be tested in the decays of positronium atom, the lightest bound system built of charged leptons.
Jagiellonian Positron Emission Tomograph (J-PET) device constructed from plastic scintillators, detects the photons originating from electron positron annihilation. This feature enables J-PET to...
Jakub Boratyński 1,2, Michał Jagodziński 1,2 and Zbigniew Rogulski 2
1 Centrum Produkcji Radiofarmaceutyków VOXEL S.A, ul. Wrocławska 1-3, 30-006 Kraków,
2 Wydział Chemii, Centrum Nauk Biologiczno-Chemicznych, Uniwersytet Warszawski, ul. Żwirki i Wigury 101, 02-089 Warszawa
E-mail: j.boratynski@voxel.pl
The 68Ga isotope is usually eluted from the 68Ge/68Ga generator and is...
One of the most important challenges in hadron therapy is the development of online monitoring techniques. Monitoring systems based on the detection of secondary radiation such as prompt gamma (PG) emission produced during treatment are promising approaches for this purpose [1,2]. The SiFi-CC, a Compton camera based on stacks of heavy scintillating fibers and SiPMs, is being developed for PG...
Stable development of fission-based nuclear energy facilities requires the safe management of spent nuclear fuel. The growing number spent nuclear fuel in dry storage casks in intermediate storage sites around the world require efficient tools for non-destructive routine verifications of safe storage of spent fuel assemblies. Using a cosmic ray muon for screening of spent nuclear fuel in dry...
Positronium, a bound state of positron and electron has been proposed as a novel biomarker for examining cancer cells [1]. This atom is copiously created in cells during Positron Emission Tomography (PET) imaging [2-3].Our pre-clinical studies have shown significant differences in the lifetime of positronium between normal and neoplastic cells and tissues [4-5]. Due to the conversion process...
Impact of PRRT with the use of 90Y/177LuDOTA-TATE to change of SUVs obtained in 68Ga-DOTA-TATE PET/CT in patients with neuroendocrine tumors – does the use of a theroanostic pair of radiopharmaceuticals may affect the estimation of survival after PRRT?
Introduction
Peptide receptor radionuclide therapy (PRRT) is an effective therapeutic option for metastatic neuroendocrine tumor (NET)...
Key words:
myocardial perfusion, nuclear medicine, SPECT/CT, image quality
Background:
Myocardial perfusion imaging with 99mTc-MIBI by SPECT/CT plays a major role in the diagnosis of coronary artery disease (CAD) as a non-invasive test to assess perfusion in cardiomyocytes. The exam allows to assess the severity of the disease, the effectiveness of the therapy, and has a...
Poly(amidoamine) (PAMAM) dendrimers are monodisperse synthetic polymers with nanosize ranging from 1-14nm. Dendrimer synthesis can be precisely controlled in size, shape, molecular mass, composition, and reactivity [1,2]. The study's main aim was to investigate the correlation between the physicochemical properties of the carrier and the active substance and the efficiency of the PAMAM-5FU...
Spheroids are three-dimensional cancer cell models able to mimic important properties of real tumors such as physical structure, physiological characteristics, and gene expression patterns. In this research, the lifetime of Positronium has been evaluated in spheroids formed from human melanoma cell lines, WM266-4 and WM115. In the first step, spheroids were formed from WM266-4 and WM115...
Agata Jędruszczak for the J-PET collaboration
agatajedruszczak1999@gmail.com
Jagiellonian University in Kraków; Faculty of Physics, Astronomy and Applied Computer Science, Profesora Stanisława Łojasiewicza 11, 30-348 Kraków
The poster shows the results of the research on the absorption in the brain of gamma quanta from positronium atoms created during the PET imaging.
Positronium...
Extracellular vesicles (EVs) are a spherical shape structures surrounded by a protein-lipid membrane. EVs are important in the detection of various diseases, such as cardiovascular disease or cancer, and may have a high therapeutic potential [1]. The molecular composition and size of EVs membranes vary depending on the source cells, the current stage of development and environmental...
Positron annihilation lifetime spectroscopy (PALS) has been used less extensively in studies with biological material, although its use in interrogating free volume, voids and defects in polymers is well established. There exist a number of results, e. g. by E. Kubicz and the J-PET group [1], showing the correlation between cell structure and the PALS parameters, such as mean...
Nanotechnology is a combination of science, engineering and technology in a nanoscale. This revolutionary technics is used in many fields of science and life [1,2]. Advances in nanotechnology resulted in the development of theranostic nanoparticles constituting the diagnostic and therapeutic agent in a single particles [3]. Such features are possessed, among others, by magnetite nanoparticles...
The purpose of the presented investigation is to compare the sensitivity, specificity, PPV, and NPV for standard mammography, spectral mammography, ultrasound, and magnetic resource imaging (MRI), which are the commercially available imaging modalities for breast cancer. The aim of our investigation is to design, construct and establish the performance characteristics of the Jagiellonian...
The aim of this study was to analyzed the differences between the reconstruction of the patient's anatomy in the therapeutic area, performed with the use of the X-ray Volume Imaging system (XVI) of the Elekta system, and the actual patient positioning. The results obtained from the cone beam tomography (CBCT) performed twice (before and after irradiation) were compared with the reference...
