Speaker
Description
Damian Kaniowski,a Katarzyna Ebenryter-Olbińska,a Katarzyna Kulik,a Slawomir Janczak,b Anna Maciaszek,a Katarzyna Bednarska-Szczepaniak,b Barbara Nawrota and Zbigniew J. Leśnikowskib
aCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland; bInstitute of Medical Biology, Polish Academy of Sciences, Lodowa 106 92-232, Lodz, Poland
Nucleic acids, while retaining their status as “the molecules of life,” are becoming “molecular wires,” i.e., materials for the construction of molecular structures at the junction between the biological and inorganic worlds [1]. Natural as well as modified nucleic acids are used in practice. Unmodified nucleic acids are easily accessible because of the availability of automated chemical methods for nucleic acids synthesis, but their properties are ordinary. The aim of the second approach is the incorporation of new, “unnatural” properties, which is usually performed by adding suitable labels and modifying units into nucleic acids.
One of the original openings in nucleic acids modification were derivatives containing of boron cluster (polyhedral boron hydrides) component [2]. Herein, we will discuss the use of boron clusters as a platform in the design of a new type of bioinorganic composites comprising nucleic acids and boron clusters and will discuss some of their properties and applications [3-7].
References: [1] Lesnikowski, Z.J., Cur. Org. Chem., 2007, 11, 355; [2] Lesnikowski, Z.J., Eur. J. Org. Chem., 2003, 4489; [3] Ebenryter-Olbińska, K., et al., Chem. Eur. J., 2017, 23, 16535; [4] Kaniowski, D., et al., Molecules, 2017, 22, 1393; [5] Olejniczak, A.B., et al., Int. J. Mol. Sc., 2018, 19, 3501; [6] Leśnikowski, Z.J., J. Med. Chem. 2016, 59, 7738; [7] Adamska-Bartłomiejczyk, A., et al., in “Boron-Based Compounds: Potential and Emerging Applications in Medicine”, (E-M. Hey-Hawkins, C. Vinas-Teixidor, Eds.,), John Wiley & Sons, Inc., Chapter 1.2, pp 20-34, 2018.
Acknowledgments: This work was supported in part by the National Science Center, Poland, grant 015/16/W/ST5/00413. Contributions from the Statutory Fund of IMB PAS (S.J, Z.J.L., K.B-S) and CMMS PAS (B.N., K.E-O., K.K., D.K., A.M.) are also gratefully acknowledged.
