23-28 June 2019
Collegium Maius
Europe/Warsaw timezone

Investigations on physical and biological range uncertainties in Krakow proton beam therapy centre

24 Jun 2019, 11:20
25m
Collegium Maius

Collegium Maius

Jagiellońska 15 Street, Kraków
invited talk Monday

Speaker

Prof. Antoni Ruciński (Institute of Nuclear Physics PAN)

Description

The physical and biological range uncertainties are limiting the clinical potential of proton beam therapy (PBT). Our research activities aim at developing software tools and detector instrumentation to tackle the problem of beam range uncertainties in the clinic. We will present research activities performed by our group within national and international collaborations in the perspective of recent advances in the field of proton therapy medical physics.

We will report on our development and pre-clinical application of a GPU-accelerated Monte Carlo (MC) simulation toolkit FRED. The MC based recalculation of patient treatment plans with variable radiobiological effectiveness is an essential input for medical doctors and physicists and can support PBT treatment planning. Taking advantage from the FRED time performance we aim to improve quality assurance efficiency in Krakow PBT facility. The software tools and procedures developed are currently integrated into the cancer patient treatment procedures to fully exploit the advantages of proton beams in the clinic.

We will report on our investigations of plastic scintillator based PET detectors for monitoring of particle therapy delivery. We study the feasibility of Jagiellonian-PET detector technology for proton beam therapy range monitoring by means of MC simulations of the β+ activity induced in a phantom using proton beams. The experimental validation and image reconstruction activities are ongoing.

Using a GPU-accelerated Monte Carlo simulation toolkit FRED and plastic scintillator based PET detectors we aim to improve patient treatment quality with protons.

Primary author

Prof. Antoni Ruciński (Institute of Nuclear Physics PAN)

Co-authors

Jakub Baran ( Institute of Nuclear Physics PAN) Prof. Giuseppe Battistoni (INFN, TIFPA) A Chrostowska (Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Cracow Branch) Prof. Marco Durante (Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Technische Universität Darmstadt, Institut für Festkörperphysik) Dr Jan Gajewski (Institute of Nuclear Physics PAN) Magdalena Garbacz (Institute of Nuclear Physics PAN) Kamil Kisielewicz (Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Cracow Branch) Dr Nils Krah (University Lyon, CNRS, CREATIS UMR 5220, Centre Léon Bérard) Prof. Vincenzo Patera (Sapienza University of Rome) Monika Pawlik-Niedźwiecka (Institute of Physics, Jagiellonian University) Dr Ilaria Rinaldi (ZonPCT/Maastro clinic) B Rozwadowska-Bogusz (Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Cracow Branch) Prof. Emanuele Scifoni (TIFPA) Agata Skrzypek (Institute of Nuclear Physics PAN) Dr Francesco Tommasino (TIFPA, University of Trento) Prof. Angelo Schiavi (Sapienza University of Rome) Prof. Pawel Moskal (Institute of Physics, Jagiellonian University)

Presentation Materials