BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CERN//INDICO//EN BEGIN:VEVENT SUMMARY:Polymer and composite carriers for controlled drug release DTSTART;VALUE=DATE-TIME:20220714T130500Z DTEND;VALUE=DATE-TIME:20220714T132500Z DTSTAMP;VALUE=DATE-TIME:20261008T191327Z UID:indico-contribution-53-719@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Marek Gorgol\; Maria Curie-Sklodowska University\, P oland ()\nDelivering of the active pharmaceutical ingredients (APIs) to th e organism in the desired manner is a great challenge. Therefore\, it is i mportant to develop and investigate new systems\, allowing to control both the rate and the period of drug delivery. In such systems\, the carrier\, in which API is dissolved\, can and should be designed and/or modified in a way which allows to control the infiltration of the dissolution medium into the system\, resulting in a modification of API release. The porous m atrices seem to be suitable carriers for this purpose\, as a solid dispers ion of the drug can be formed inside of them.\nSeveral solid API dispersio ns have been developed with diclofenac sodium as API and porous carriers s uch as mesoporous polymers: poly(trimethylolpropane trimethacrylate) (poly (TRIM))\, and commercially available Amberlite® XAD7HP as well as polymer -silica composites [1]. Additionally\, selected carriers were modified by functionalizing with 3-aminopropyl groups or tableting by mechanical compr ession.\nThe rate of the diclofenac sodium release from each of solid disp ersions was examined in vitro to assess their usefulness for the controlle d release. The use of XAD7HP with small amount of API and poly(TRIM) funct ionalized with 3-aminopropyl groups as porous carriers gave satisfying res ults\, with the drug release profile quite close to linear\, Unfortunately \, good release profiles were obtained at the expense of reducing the amou nt of released API from nearly 100% to about 50% after 24 hours. It is als o worth to mention\, that increasing the amount of diclofenac sodium added into XAD7HP caused nonhomogeneous distribution of API inside a carrier an d gave non-satisfying results in the release profile.\nTo better understan d the course of the drug release\, the initial distribution of diclofenac sodium within the carrier for each solid dispersions as well as the distri bution of remaining diclofenac sodium after various release times for sele cted samples were studied. The morphology and the spatial distribution of the elements in sample cross-sections were determined with scanning electr on microscopy (SEM) coupled with energy dispersive spectroscopy (EDS). The porosity of the investigated systems was characterized with classic low-t emperature N2 adsorption porosimetry and positron porosimetry based on pos itron annihilation lifetime spectroscopy (PALS).\n\n[1] A. Kierys\, R. Zal eski\, M. Grochowicz\, M. Gorgol and A. Sienkiewicz\, Micropor Mesopor Mat \, 294\, 109881 (2020).\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contri butions/719/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/719/ END:VEVENT BEGIN:VEVENT SUMMARY:Mesoporous silica carriers for controlled drug release DTSTART;VALUE=DATE-TIME:20220714T124500Z DTEND;VALUE=DATE-TIME:20220714T130500Z DTSTAMP;VALUE=DATE-TIME:20261008T191327Z UID:indico-contribution-53-705@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Radek Zaleski\; Maria Curie-Skłodowska University\, Poland ()\nOne of the most important challenges in modern medicine is to ensure the desired course of delivery of active pharmaceutical ingredients (APIs) to the patient’s body. Therefore\, many studies are devoted to n ew delivery systems that can control both rate and period of drug delivery as well as the place of their administration. An important factor to cons ider when designing controlled release systems is the solubility of the AP I in the aqueous environment. Using an appropriately designed carrier allo ws to control the infiltration of the dissolving medium into the system\, resulting in a modification of the release of API. Among others\, the carr iers suitable for achieving this goal are porous matrices\, in which a sol id dispersion of the drug is formed.\nThe ordered mesoporous silica SBA-15 (carrier) and diclofenac sodium (API) were used to develop a controlled d rug release system. The release rate of diclofenac sodium was tested in vi tro to evaluate the suitability of this system for API release control. Fo r tabletted SBA-15\, it was possible to achieve a release course close to the desired linear release profile with release of about 50% API after 24 hours.\nFurther improvement of the release system requires insight into th e course of API release through its detailed study. The distributions of d iclofenac sodium within the carrier were studied for systems before releas e and after various release times. Scanning electron microscopy (SEM) coup led with energy dispersive spectroscopy (EDS) was used to determine the mo rphology and the spatial distribution of the elements. Free volumes rangin g in size from angstroms to nanometers were characterized with nitrogen ad sorption and positron annihilation lifetime spectroscopy (PALS). The resul ts obtained with these techniques allow to infer how the microstructure of the carrier-API system influences the drug release.\n\nhttps://indico.koz a.if.uj.edu.pl/event/7/contributions/705/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/705/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Compartmental models – a useful tool for medical t herapy and diagnosis DTSTART;VALUE=DATE-TIME:20220714T122500Z DTEND;VALUE=DATE-TIME:20220714T124500Z DTSTAMP;VALUE=DATE-TIME:20261008T191327Z UID:indico-contribution-53-704@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Aleksandra Jung\; AGH University of Science and Tech nology\, Poland ()\nAmong many computational methods\, compartmental model s are still attractive for many applications in medicine\, both in the fie lds of therapy and diagnosis. Below relevant examples are presented\, they are based on literature and own research results.\n\nKinetics models base d on differential equations are common for dose estimation in extracorpore al therapies. Hemodialysis adequacy considers methods based on experimenta l data providing to different measures like Kt/V or equivalent renal funct ion. This can be improved by adding additional dialysis adequacy indices t ested by numerical simulations. Mathematical models may accurately reprodu ce the clinical data of adequacy markers like urea or creatinine. In extra corporeal liver support therapies (ELS) considerable efforts focus on dose parameter estimation\, correct identification of compartment volumes and transfer coefficients parameters. A limited amount of clinical data in thi s case can be resolved by combined models of kinetics of the two substance s: bilirubin and urea. Building new models for ELS may also be partially s upported by the use of physiological models of bile acid kinetics previous ly described in the literature.\n\nThe outcome of the model depends on its structure\, parameters and initial conditions. Therefore\, it is necessar y to investigate the sensitivity of applied parameters\, especially when t he number of observation points is limited as it facilitates to decide the sampling rate in clinical practice. The accuracy of the parameter estimat ion may be improved if the sampling time is selected individually for each patient near the peak values of the sensitivity. This is beneficial both for the individualization of therapy assessment for a single patient and f or the preparation of a new complete clinical trial protocol.\n\nCompartme nt models describing the kinetics of radiolabeled substances are successfu lly used to support PET and SPECT imaging diagnostics where radiopharmaceu ticals are used routinely. The results of the mathematical model allow\, i n this case\, to obtain additional detailed diagnostic information. Models are also useful for comparing the diagnostic value of PET and SPECT tests \, for distinguishing malignant neoplasms from inflammations or other beni gn changes\, for assessing the diagnostic value of new radiopharmaceutical s or for assessing the impact of disturbances on the results of estimated physiological parameters. Additionally\, they are applied to evaluate the results of magnetic resonance imaging or to differentiate the severity of Helicobacter pylori infection based on the result of a C-14 labeled urea b reath test.\n\nLast but not least\, a clinically important area of applica tion of this type of models is the assessment of radiological exposure dur ing radiopharmaceutical exams\, but also in the assessment of the accumula tion of selected elements in our body\, e.g. lead.\n\nIn each of the above -mentioned applications\, the key is to define the initial assumptions and to properly adjust the complexity of the model to the amount of available experimental data and then to verify the model. Despite their limitations compartmental models can be used to identify meaningful physiological par ameters helpful in making the correct diagnosis or selecting the appropria te therapeutic dose.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contribut ions/704/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/704/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: PET-MRI nanotheranostics with radio-labelled nanoparticl es DTSTART;VALUE=DATE-TIME:20220714T120000Z DTEND;VALUE=DATE-TIME:20220714T122500Z DTSTAMP;VALUE=DATE-TIME:20261008T191327Z UID:indico-contribution-53-702@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Zdenka Kuncic\; University of Sydney\, Australia ()\ nIn radiation oncology and nuclear medicine\, the efficacy of theranostic strategies (i.e. combining treatment with diagnostic imaging) may be drama tically improved by leveraging the unique properties of nanoparticles. Due to their nanoscale size\, nanoparticles can penetrate target tissues and tumour cells\, and enhance physico-chemical reaction rates. In this talk\, I will discuss the opportunities presented by superparamagnetic nanoparti cles\, which\, when labelled with suitable radioisotopes\, offer a means f or realising PET-MRI theranostics. I will present results on a novel chela te-free technique for radio-labelling superparamagnetic nanoparticles with clinically relevant isotopes and discuss how such nanoparticles can impro ve the overall image quality of PET-MRI. I will also discuss how radio-lab elling superparamagnetic nanoparticles with therapeutic isotopes presents an opportunity for enhancing internal targeted radiotherapy by leveraging MRI guidance and nanoparticle radio-enhancement effects.\n\nhttps://indico .koza.if.uj.edu.pl/event/7/contributions/702/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/702/ END:VEVENT END:VCALENDAR