BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CERN//INDICO//EN BEGIN:VEVENT SUMMARY:Dose distribution comparison of cerebrospinal axis irradiation. He lical Tomotherapy vs. Proton Pencil Beam Scanning DTSTART;VALUE=DATE-TIME:20220714T094000Z DTEND;VALUE=DATE-TIME:20220714T100000Z DTSTAMP;VALUE=DATE-TIME:20260720T182844Z UID:indico-contribution-52-701@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Bartosz Kiełtyka\; The University Hospital in Krako w\, Poland ()\nBackground\nRadiotherapeutic treatment performed in cerebro spinal axis becomes more common in oncological practice. Central nervous s ystem (CNS) malignant tumors are diagnosed in 1-2% of all adult patients. Most cases are regarding brain tumors in which a combined treatment is a s tandard of care: surgical resection\, radiotherapy (RT) and chemotherapy ( CHT).\nIn clinical practice\, the most frequent techniques in external bea m RT are related to dynamic techniques based on a standard medical acceler ator. The treatment is prepared in fractionation scheme 1.8-2.0 Gy / fract ion in 25-30 fractions.\nRecently\, tomotherapy is used to irradiate long and symmetrical types of structures\, however published clinical results a re sparse. Proton beam irradiation (PBI) is another treatment mode althoug h less available in most countries.\nThe aim of this study is to compare d ose distributions in treatment plans for the cerebrospinal axis irradiatio n using photon and proton techniques.\n\nMaterial and methods\nThe aim of the study is to compare dose distributions in treatment plans for the cere brospinal axis irradiation. Photon and proton techniques were used to prep are RT plans. To create a photon tomotherapy plan in helical technique imp lemented on the Radixact apparatus\, a treatment planning system (TPS) Pre cision\, Accuray\, was used. In case of proton RT planning\, TPS Eclipse ( Varian) was used in scanning beam mode.\nIn this study\, six treatment cas es were analyzed. In both mentioned techniques the same tomographic scans and contours of the critical organs (RT Structures) were used for treatmen t plan preparation. used for Then the comparison of prepared plans was per formed on RayStation\, RaySearch Laboratories software.\nDose distribution s in the target and critical organs were analyzed in terms of uniformity\, maximum\, average\, minimum dose for target and integral dose. The high d ose gradient areas that represent the resilience of treatment plans to unc ertainties related to patient positioning and organ mobility were also inv estigated. The technique of proton radiotherapy requires joining the field s. Field joints were subjected to deep analysis. Duration of treatment was also compared.\n\nResults and conclusions\nThe dose distributions obtaine d in proton plans are much more favorable in terms of the protection of cr itical organs and the integral dose reduction\, which is very important in case of pediatric patients reducing the risk of secondary cancer inductio n. On the other hand\, the treatment plans prepared for the photon helical technique are characterized by a greater dose distribution homogeneity in the areas where fields needed to be joined in proton techniques. Those ph oton plans were proved to be less sensitive to errors resulting from the g eometry of the patient's position. For both techniques similar irradiation times were obtained. Each technique has its own benefits and depending on availability might be applied in the treatment of adult CNS malignant tum ors.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/701/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/701/ END:VEVENT BEGIN:VEVENT SUMMARY:Safe proton radiotherapy for patients with metallic spine stabiliz ation system DTSTART;VALUE=DATE-TIME:20220714T092000Z DTEND;VALUE=DATE-TIME:20220714T094000Z DTSTAMP;VALUE=DATE-TIME:20260720T182844Z UID:indico-contribution-52-700@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kamil Kieislewicz\;Centre of Oncology\, Maria Sklodo wska-Curie Memorial Institute Krakow Branch\, Poland ()\nIntroduction\nSin ce the beginning of proton radiotherapy in Krakow\, skull base tumors are the main sites treated here. Due to the need to deliver a high dose of ion izing radiation (70-74Gy RBE) and the close presence of critical structure s\, such brainstem\, optic chiasm\, optic nerves\, the use of a proton bea m creates better opportunities for dose escalation to the target volume co mpared to photon radiotherapy. The problem when planning such treatment is the presence of metal stabilizers in about 40% of patients\, which increa se the uncertainty of the planned dose deposition.\n\nMaterial and methods \nAcquisitions of CT layers necessary for treatment planning were performe d on the Siemens Somatom Definition AS apparatus using the iMAR\, an optim ized iterative algorithm for reducing metal artifacts. Then\, a dedicated calibration curve for the Varian Eclipse treatment planning system (HU vs. RSP) was prepared. For each patient with a stabilizer\, computed tomograp hy was additionally reconstructed in the extended HU scale to transfer the necessary information about the implant density for treatment planning al gorithm. Treatment plans were also based on individually defined structure s - so-called target per field (volume to be irradiated from a given thera peutic field - beam) in order to avoid fragmented areas of artifacts recon structed in an unacceptable way. The geometry of the beams was also optimi zed in relation to the metal element and critical organs.\n\nResults and c onclusions\nThe presented procedure allowed for the safe proton radiothera py treatment using scanning beam in over 50 patients with metallic stabili zers\, which was additionally confirmed by Monte Carlo simulations with th e FRED tool (Fast paRticle thErapy Dose evaluator).\n\nhttps://indico.koza .if.uj.edu.pl/event/7/contributions/700/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/700/ END:VEVENT BEGIN:VEVENT SUMMARY:Towards including radiation quality in proton therapy treatment pl anning and dosimetry DTSTART;VALUE=DATE-TIME:20220714T090000Z DTEND;VALUE=DATE-TIME:20220714T092000Z DTSTAMP;VALUE=DATE-TIME:20260720T182844Z UID:indico-contribution-52-699@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jan Gajewski\; Institute of Nuclear Physics Polish A cademy of Sciences\, Poland ()\nProton radiotherapy is recognised as an ef fective treatment method of tumours\, which allows for increased sparing o f normal tissues compared to conventional radiotherapy. Further improvemen t of clinical proton radiotherapy can be obtained with development of adva nced treatment planning and dosimetry methods. The uncertainties in the bi ological modelling of the radiation effectiveness pose the major limitatio n of this treatment modality\, which increases the risk of complications c aused by proton irradiations\, such as the development of secondary tumour s or necrosis. Therefore\, one of the main challenges in proton radiothera py is to improve the current strategies of treatment planning by accountin g for radiation quality described by means of the particle stopping power (Linear Energy Transfer - LET). Nowadays\, LET is not considered in the cl inical routine of treatment planning and dosimetry even if its engagement would fully allow to exploit the clinical advantages of proton radiotherap y.\n\nWithin the seminar\, an overview of the computational and experiment al methods for proton therapy treatment planning and dosimetry\, clinicall y used at CCB and in other proton facilities will be presented. Moreover\, it will be shown how to introduce radiation quality information in proton treatment. This part includes the development of (i) dosimetrical methods based on TimePix semiconductor pixel detectors developed in the framework of the CERN Medipix collaboration and (ii) computational methods based on fast GPU-accelerated Monte Carlo codes. The inclusion of radiation qualit y in the treatment planning and dosimetry has the potential to improve the precision of patient treatment in proton therapy.\n\nhttps://indico.koza. if.uj.edu.pl/event/7/contributions/699/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/699/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Research in Neutron Capture Therapy at University of Pavia DTSTART;VALUE=DATE-TIME:20220714T084000Z DTEND;VALUE=DATE-TIME:20220714T090000Z DTSTAMP;VALUE=DATE-TIME:20260720T182844Z UID:indico-contribution-52-698@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Saverio Altieri\; University of Pavia\, Italy ()\nBo ron Neutron Capture Therapy (BNCT) is an experimental radiotherapy treatme nt characterised by selectivity at the cellular level based on the 10B(n\, alpha)7Li reaction induced by thermal neutrons\; the reaction products\, a lpha and 7Li have a biological efficacy comparable to that of C-ions used in Hadrontherapy\; and they have the added advantage of being produced dir ectly in the tumour cells\, where they release their destructive energy\, without having to pass through the layers of healthy tissue overlying the tumour.\n\nToday\, the international BNCT community\, after its experience with neutron from research nuclear reactors\, finally has sources produce d with proton accelerators via p\,Be or p\,Li reactions. Accelerators have the advantage of being easy to install in a clinical facility and therefo re offer the possibility to treat patients in a more appropriate environme nt.\n\nThe University of Pavia has a long tradition in the field of BNCT b ased on the use of the Triga Mark II nuclear research reactor of the LENA laboratory\; here in the past BNCT was applied to treat diffuse liver meta stases\, using the auto-transplantation technique with the irradiation of the explanted liver in the reactor's Thermal Column.\n\nToday\, preclinica l research\, in collaboration with INFN\, many Italian Universities and in ternational Institutions and Laboratories\, is still very active on variou s aspects of BNCT: research into new boron carriers with in vitro and in v ivo toxicity and efficacy tests\, measurement of boron concentration in bi ological samples by alpha spectrometry\, neutron autoradiography\, online measurement of boron dose by SPECT and/or Compton Camera technique with Cd ZnTe (CZT) detectors.\n\nUNIPV has an intense collaboration with the Centr e for Oncology Hadrontherapy (CNAO) where a BNCT facility based on the TAE -TLS p-Li accelerator will be ready in a couple of years. Two treatment ro oms are planned\, one dedicated to patients and one to BNCT research.\n\nI n the talk\, after a brief introduction to the BNCT technique\, the above- mentioned topics will be presented.\n\nhttps://indico.koza.if.uj.edu.pl/ev ent/7/contributions/698/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/698/ END:VEVENT END:VCALENDAR