BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CERN//INDICO//EN BEGIN:VEVENT SUMMARY:Design of spread-out Bragg peaks in spatially fractionation proton therapy DTSTART;VALUE=DATE-TIME:20220712T082900Z DTEND;VALUE=DATE-TIME:20220712T083100Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-740@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Agata Tobola-Galus\; Institute Of Nuclear Physics Po lish Academy od Sciences\, Poland ()\nAuthor: Agata Tobola-Galus\nCo-autho rs: Jan Swakoń\, Paweł Olko\nPurpose\n\nIn spatially fractionated proton therapy SFTP (proton grid therapy) the arrays of parallel and pencil prot on beams generated by grid collimator are applied to reduce the impact of irradiation on healthy tissue. At the beam entrance the locally irradiated skin benefits from the ununiform profile of beam causing faster repair of irradiated tissues. In the same time\, due to the multiple Coulomb scatte ring of the proton beam\, the target volume can be uniformly irradiated. I n this paper\, use of proton grid therapy is considered designe Spread-Out Bragg Peak (SOBP) at the target depth. The aim of these studies was dosim etry verification produced grid collimator and range modulator to form uni form SOBP for spatially fractionated proton beams.\nMaterial and Methods\n The experimental verification of the depth dose distribution was performed at the eye proton therapy unit with 60 MeV proton beam from AIC-144 cyclo tron at IFJ PAN Krakow. Mesh-like brass collimators with the lateral centr e-to-centre (c-t-c) spots distances of 2 mm (spot diameter 1 mm were prepa red were prepared. A spread out Bragg peaks (SOBP) of half modulation (fro m 1.5 cm to 3 cm-depth in water) and full modulation were formed by specia lly designed for this collimator range modulators. ProBImS scintillator sy stem with a CCD camera were placed at several depths in a solid-water slab phantom to evaluate the relative 2-D dose distribution. As a figure of me rit\, the ratio between the central dose of one minibeam (peak dose) and t he dose in the middle of two consecutive beams (valley dose) was evaluated . This magnitude\, named peak-to-valley dose ratio (PVDR)\, is a very rele vant parameter in such spatially fractionated techniques. The dosimetry wa s complemented by measurements of the depth dose distribution performed in water phantom using the Markus ionization chamber and 2D-TLD in the solid phantom.\n\nResults\nOur results show that for parallel beams 1 mm in dia meter with c-t-c 2 mm\, the optimal distance of the collimator from the ey elid surface is 35 mm\, obtaining an almost uniform dose in the target and satifiable values of PVDR (3-5) in the region of the beam entrance. A dec rease in the PVDR value is observed with increasing distance of the phanto m from the collimator. Changing the distance of the measurement system fro m the grid collimator (snout) affects the shape of the dose depth distribu tion. The differences are not large\, mainly an increase of the dose at th e entrance\, and negative slope of the plateau are observed.\n\nConclusion s\nSpatially fractionated proton therapy SFPT (proton grid therapy) is bei ng considered for the treatment of eye tumors. A favorable dose distributi on at the beam entry would allow the eye to be irradiated through closed e yelid sparingly due to spatial fractionated dose.\nDesigning range modulat or wheels to SOBP for parallel proton min-beams with energy of 60 MeV\, an d diameter of 1 mm were found to be sufficient achieve homogeneous irradia tion of the target and to obtain a flat plateau SOBP with full and half mo dulation.\nThe results of this work can be used to guide future radiobiolo gical experiments using artificial skin.\n\nThis project has received fund ing from the European Union's H2020 Research and Innovation Programme\, un der Grant Agreement No: 730983\n\nhttps://indico.koza.if.uj.edu.pl/event/7 /contributions/740/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/740/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Influence of physical uncertainties on proton radiot herapy of moving targets DTSTART;VALUE=DATE-TIME:20220712T065500Z DTEND;VALUE=DATE-TIME:20220712T071500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-666@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Renata Kopeć\; Institute of Nuclear Physics\, Polis h Academy of Sciences\, Poland ()\nhttps://indico.koza.if.uj.edu.pl/event/ 7/contributions/666/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/666/ END:VEVENT BEGIN:VEVENT SUMMARY:Angular DOI Calibration Methods towards PET In-System Calibration of (Semi-)Monolithic Scintillators DTSTART;VALUE=DATE-TIME:20220712T083100Z DTEND;VALUE=DATE-TIME:20220712T083300Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-741@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Yannick Kuhl\; RWTH Aachen University\, Germany ()\n Author: Yannick Kuhl\nCo-authors: Florian Mueller\, Stephan Naunheim\, Dav id Schug\, Volkmar Schulz\n\nIntroduction\nAvailable clinical positron emi ssion tomography (PET) systems commonly consist of one-layer segmented det ector arrays with planar 2D gamma positioning. However\, without 3D positi oning in the additional depth-of-interaction (DOI) direction the system’ s spatial resolution is reduced at off-centered positions due to parallax errors. This effect is particularly relevant for small ring diameters\, or for total body PET devices with a large axial field of view. Monolithic a nd semi-monolithic detectors represent an attractive alternative with over all good performance characteristics and intrinsic DOI capability. Current ly\, the best positioning performance of (semi-)monolithic detectors is ac hieved with individual calibration and subsequent processing\, e.g.\, with machine learning-based gamma position estimation routines. Detector calib ration describes the process of acquiring a dataset of gamma interactions in the detector at known positions to generate\, e.g.\, a training dataset for machine learning-based preprocessing approaches. In this work\, the m achine learning technique gradient tree boosting (GTB) is used that establ ishes a relationship between the known gamma interaction position and its light distribution and is thus able to assign an interaction position to u nknown light distributions. However\, the individual calibration is time-c onsuming\, especially for large PET systems\, with calibration times of se veral days per detector using a conventional parallel hole beam collimator . By introducing a fan beam collimator\, also used in this work\, the proc ess can be accelerated to hours per detector and even to minutes with the adaption to a multi fan beam collimator utilizing several fan beams at the same time.\nCurrently\, however\, these methods are only prepared for cal ibration in test setups\, making it tedious to recalibrate the detectors o nce they have been installed in the PET system. A re-calibration may be ne cessary due to changes in measurement parameters\, such as changes in temp erature or bias voltage\, as well as aging of the detector components. The refore\, an in-system calibration technique may be necessary to establish (semi-)monolithic detectors in a system. For planar calibration with gamma irradiation along the detector normal only an adjustment of the setup is necessary. For DOI calibration with currently proven lateral detector irra diation\, however\, a new calibration method must be developed since the d etector sides are inaccessible in a ring.\nThe challenge for in-system cal ibration is now to generate an appropriate DOI training dataset with known irradiation position\, exclusively by measurements in the installed PET s ystem. As a proposed solution\, this work introduces two DOI calibration r outines based on angular detector irradiation.\n\nMaterials\nThe coinciden ce setup consists of a fan beam collimator and two PET detectors based on 8 semi-monolithic LYSO slabs with a height of 19 mm and a width of 3.9 mm coupled to a DPC3200-22 dSiPM (PDPC). One of the detectors is the one to b e evaluated and can be rotated in steps of 11.25° between lateral irradia tion (0°) and the detector normal (90°) in relation to the fan beam plan e by a special bracket. In the set position\, the detector can be driven t hrough the fan beam using a linear translation stage to irradiate the enti re crystal volume for complete calibration datasets.\n\nAngular Irradiatio n Methods\nIn the first “monoAngle” method\, the DOI position of the g amma interactions is obtained from a previously performed planar position estimation\, based on GTB as well\, and the known geometric course of the gamma beam inside the detector.\nIn the second “duoAngle” routine\, th e DOI position is calculated geometrically from the intersection of two su ccessively irradiated beams and then assigned to the gamma interactions wi thin that intersection. The main task here is to find the gamma interactio ns in the area around the intersection. The initial assumption is that the light distributions of both beams are similar at the intersection. An ite rative\, mutual search algorithm narrowing down the light distributions vi a similarity to this intersection showed the best results. In this iterati ve search\, each light distribution of one beam is compared with all gamma interactions of the other beam for similarity using a Nearest Neighbor ro utine with a Euclidean distance metric\, applied to the inverse optical ph oton counts. 20% of the most dissimilar gamma interactions per beam are di scarded per iteration until a termination criterion is reached\, which is based on the Lambert-Beer law and the penetration depth of the beams. Furt her calculated features based on the light distribution as a supplement sh owed no improvement. Using a planar position estimation\, based on GTB and performed in advance\, the gamma interactions in question can be restrict ed to a planar Y-position range around the intersection prior to the itera tive search.\n\nResults and Conclusion\nBoth methods showed a positioning performance within 5 % to the lateral irradiation (0°) up to an irradiati on angle of 45°. Thus\, both methods are suitable candidates for in-syste m calibration. Comparing monoAngle and duoAngle\, the monoAngle method is simpler in application and implementation and could provide even better po sitioning performance for higher resolution detectors than those used here .\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/741/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/741/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Dose-3D - towards measuring radiation dose with spat ial granulation DTSTART;VALUE=DATE-TIME:20220712T071500Z DTEND;VALUE=DATE-TIME:20220712T073500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-667@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Tomasz Szumlak\; AGH University of Science and Techn ology\, Poland ()\nIn this talk\, I introduce a breakthrough idea of a det ector with a 3D active measuring matrix capable of sampling the spatial di stribution of the radiation dose. Such a device can perform a measurement in quasi-real-time and may bring the quality control of delivered therapeu tic dose and the personalisation of the treatment plans to a new level.\n\ nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/667/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/667/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: A new perspective for NCT: besides cancer\, can it b e effectively used for Alzheimer’s disease? DTSTART;VALUE=DATE-TIME:20220712T073500Z DTEND;VALUE=DATE-TIME:20220712T075500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-668@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Nicoletta Protti\; Pavia University\, Italy ()\nNeut ron Capture Therapy (NCT)\, since its first theoretical hypothesis of 1936 [1]\, was understood and applied mainly as a cancer treatment with few an d occasional studies regarding other diseases [2\,3]. Indeed\, the high LE T secondaries of 10B neutron capture reactions with their short ranges in tissues (less than 10 μm) makes the treatment selective at the single cel l level\, opening the route for an effective “locally activated” hadro ntherapy useful for challenging scenarios such as wide spread tumours [4] and micro-infiltrating malignancies [5]. As cancer treatment\, it is actua lly more correct to speak of BNCT being B10 almost the sole nuclide in cli nical use and under investigation for future NCT agents.\nGadolinium\, in particular the isotope 157 (Gd157)\, aroused the interest of the scientifi c community since a while [6]. The extremely short ranges of the charged s econdaries (internal conversion and Auger electrons) set a very strong con straint on the NCT agent localisation inside the targeted cell which must bind DNA molecule directly. Nonetheless\, the spread clinical use of Gd-en riched systems as MRI-probes prevents the definitive decline of the intere st in GdNCT [7].\nAlzheimer’s disease (AD) is the most common form of de mentia (50-60% of all cases) [8]. Currently over 55 million people worldwi de live with dementia and the number is expected to rise up to 139 million by 2050. Statistics say a new case of dementia arise somewhere in the wor ld every 3 seconds. AD destroys nerve cells thus limiting or abolishing hi gher brain functions (memory\, mobility\, behaviour…). In the most advan ced stages\, patients are unable to care for themselves and need constant help with their daily life. This means huge costs\, economically and psych ologically\, and indeed if we consider dementia as a country it would be t he 14th largest economy worldwide\, with a US$ 1.3 trillion current cost.\ nDespite the ongoing debate on AD pathogenesis and development\, still the central role of the misfolded beta amyloid protein (Aβ) is widely accept ed. In particular\, recent studies [9] identified the oligomers\, one of t he first stages of aggregation of Aβ\, as the most neurotoxic species thu s supporting researchers of innovative treatments for AD.\nIn the late 199 0’s\, the effectiveness of conventional radiotherapy in the treatment of TracheoBronchial Amyloidosis (TBA) suggested the idea of a possible benef icial effect of photon irradiation in AD as well [10\,11]. Presently\, evi dences are under collection to demonstrate preclinically and in very small patient’s cohorts the feasibility of such treatment [12\,13].\nIn this scenario\, Pavia University (Italy) proposed a further extension of the po sitive effects of ionising radiations in AD through the EU FET project “ NECTAR": NEutron Capture enhanced Treatment of neurotoxic Amyloid aggRegat es.\nThanks to the match between the Aβ aggregates dimensions and the ran ges of B10 and Gd157 neutron capture reactions\, a depolymerisation of the aggregates is suggested by the ionisation events. In parallel\, the glia cell compartment of brain is supposed to be stimulated by the highly penet rating photons emitted by the very same capture reactions and so promoting the clearance of the Aβ debris. NECTAR will be the proof of concept at t he preclinical stage of a bimodal treatment for AD capable of being sensit ive to all the phases of aggregations of Aβ thanks to the development of specific new molecules designed to selectively bind Aβ protein.\nDue to t he progressive and chronic features of AD\, we further expect to demonstra te the effectiveness of the treatment using highly fractionated irradiatio n protocols based on low doses and low dose rates per fraction\, thanks to the evidences of a positive effect of LDIR (low dose ionising radiation) in the brain [14].\nThe presentation will deal with a general overview of NECTAR project and a brief description of the first results.\n\nBibliograp hy\n[1] Locher\, Amer J Roent\, 36:1-13 (1936)\n[2] Trivillin et al.\, Rad Environ Biopsy’s 55:467-475 (2016)\n[3] Tsuruta et al.\, in Neutron Cap ture Therapy - Principles and Applications\, Sauerwein\, Wittig\, Moss\, N akagawa Eds\, Springer-Verlag Berlin Heidelberg 2012\n[4] Zonta et al.\, A ppl Radiat Isot\, 67(7-8):S67-S75 (2009)\n[5] Alberti et al.\, Sci Rep\, 1 0:19274 (2020)\n[6] Martin et al\, Int J Radiat Biol\, 54(2):205-208 (1998 )\n[7] Narmani et al.\, J Drug Deliv Sci Tech\, 44:457-466 (2018)\n[8] htt ps://www.alzint.org\n[9] Forloni et al.\, Movement Disorders\, 31(6): 771- 781 (2016)\n[10] Neben-Wittich et al.\, Chest 132:262-267 (2007)\n[11] Bis tolfi\, Neuroradiol J 21:683-692 (2008)\n[12] Marples et al.\, Radiother O nce 118:43-51 (2016)\n[13] Cuttler et al.\, J Alzheimers Dis 80(3):1119-11 28 (2021)\n[14] Jebelli et al.\, Cureus 14(3):e23461 (2022)\n\nhttps://ind ico.koza.if.uj.edu.pl/event/7/contributions/668/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/668/ END:VEVENT BEGIN:VEVENT SUMMARY:Pilot tests of proton beam range monitoring with J-PET DTSTART;VALUE=DATE-TIME:20220712T075500Z DTEND;VALUE=DATE-TIME:20220712T081500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-669@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jakub Baran\; Jagiellonian University\, Poland ()\nh ttps://indico.koza.if.uj.edu.pl/event/7/contributions/669/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/669/ END:VEVENT BEGIN:VEVENT SUMMARY:Developing a phantom for the positronium imaging evaluation. DTSTART;VALUE=DATE-TIME:20220712T083500Z DTEND;VALUE=DATE-TIME:20220712T083700Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-743@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Gabriela Łapkiewicz\; Jagiellonian University\, Pol and ()\nAuthor: Gabriela Łapkiewicz\nCo-authors: Pawel Moskal\, Szymon Ni edźwiecki\n\nG. Łapkiewicz1\,2*\, Sz. Niedźwiecki1\,2\, P. Moskal1\,2\, on behalf of J-PET collaboration\n\n1Faculty of Physics\, Astronomy and A pplied Computer Science\, Jagiellonian University\, Cracow\, Poland\n2Cent er for Theranostics\, Jagiellonian University\, Cracow\, Poland\n\nPhantom s used in PET technique\, such as NEMA IEC allow for measurement of activi ty concentration accumulated in different volumes. New imaging method deve loped by the Jagiellonian PET collaboration in addition to the annihilatio n density distribution enables measurement of positronium lifetime [1-4]. To qualitatively determine the precision of this method it is essential to construct a phantom\, which will allow for measuring ortho-positronium li fetime alongside activity concentration.\n\nThe proposed phantom (much lik e NEMA IEC) will consist of 6 volumes of high activity accumulation immers ed in the lower activity background. Each volume will feature different me an\nlifetime of ortho-positronium. Isotopes used for measurements must not only exhibit β+ activity\, but also need to emit prompt gamma quanta (i. e. 44Sc or68G a) [5]\, [6]. In this contribution a\nmethod for controlling ortho-positronium lifetime is discussed along with preliminary results.\n \nIn order to evaluate a method for the prepration of media with different ortho-positronium lifetime we have studied the ortho-positronium lifetime in water suspension of XAD4 porous material.\nXAD4 is characterized with the average pore size of 50 Å and can absorb water up to 60% of its mass [7].\n\nFive samples of XAD4 with controlled amount of water were measured using PALS technique. Additionally one dry sample of XAD4 and one sample of pure water were measured. Obtained spectra were fitted with PALS Avalan che [8] and components corresponding to the ortho- positronium annihilatio n in XAD4 pores were established [9]. The results showed the correlation b etween the lifetime and production intensity of ortho-positronium and the concentration of XAD4 in water.\n\nAcknowledgements:\nThe authors acknowle dge support by the TEAM POIR.04.04.00-00-4204/17 program\, the NCN grant n o. 2021/42/A/ST2/00423 and the SciMat and qLife Priority Research Areas bu dget under the program Excellence Initiative - Research University at the Jagiellonian University.\n\nReferences:\n[1] P. Moskal et al.\, Positroniu m imaging with the novel multiphoton PET scanner\, Science Advances 7 (202 1)\n[2] P. Moskal\, Positronium Imaging\, 2019 IEEE Nuclear Science Sympos ium and Medical Imaging Conference (NSS/MIC) (2019) pp. 1-3\n[3] P. Moskal et al.\, Feasibility study of the positronium imaging with the J-PET tomo graph\, Phys. Med. Biol. 64 055017 (2019)\n[4] P. Moskal\, E. Ł. Stępie ń.\, Positronium as a biomarker of hypoxia\, Bio-Algorithms and Med- Syst ems 17 (2021) 311-319\n[5] T. Matulewicz\, Radioactive nuclei for β+γ PE T and theranostics: selected candidates\, Bio- Algorithms and Med-Systems 17 (2021) 235-239\n[6] J. Choiński\, M. Łyczko\, Prospects for the produ ction of radioisotopes and radiobioconjugates for theranostics\, Bio-Algor ithms and Med-Systems 17 (2021) 241-257\n[7] Sigma-Alrdrich\, XAD4 specifi cations sheet: www.sigmaaldrich.com/specification-sheets/ 304/271/XAD4-BUL K___SIGMA____.pdf\n[8] K. Dulski\, PALS Avalanche - A New PAL Spectra Anal ysis Software\, Acta. Phys. Pol. A 137 (2020) 167\n[9] K.Dulski\, The J-PE T detector-a tool for precision studies of ortho-positronium decays\, Nucl ear Inst. and Methods in Physics Research\, A 1008 (2021) 165452\n*Corresp onding author\, email: gabriela.lapkiewicz@student.uj.edu.pl\n\nhttps://in dico.koza.if.uj.edu.pl/event/7/contributions/743/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/743/ END:VEVENT BEGIN:VEVENT SUMMARY:Design and Application for a new intense positron beam at the Anti matter Laboratory in Trento DTSTART;VALUE=DATE-TIME:20220712T081500Z DTEND;VALUE=DATE-TIME:20220712T081700Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-733@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Luca Povolo\; University of Trento\, Italy ()\nAutho r: Luca Povolo\nCo-authors: Sebastiano Mariazzi\, Luca Penasa\, Ruggero Ca ravita\, Sushil Sharma\, Roberto Sennen Brusa\n\nAt the Anti-Matter Labora tory (AML) of the Department of Physics of the University of Trento a new positron beam is currently under development. It is being constructed for the production into vacuum of Positronium (Ps\, the bound state of an elec tron and the positron\, e+)\, which will be used for fundamental studies\, like inertial sensing [1]. However\, Ps is emitted into vacuum in the gro und state which has a lifetime of only 142 ns\, while studies with positro nium require lifetime in the microsecond range. This becomes possible by e xciting Ps into a metastable state via a two-photon transition\, as we dem onstrated [2].\nThe production of positronium atoms start by injecting pos itron into a target\, called e+/Ps converter [3-6]. The new positron beam of our laboratory is based on a 22Na radioactive source coupled with a sol id noble gas moderator held at cryogenic temperature [7]. Up to now we obt ained a continuous beam with up to 50000 positrons per second per milli-Cu rie. The next step will be the bunching of the continuous beam with a Buff er-Gas Penning trap [8] which will be followed by the positron bunch injec tion into the converter.\nIn this work\, we will present the preliminary d esign of the apparatus with simulations. The extraction of the positron co ntinuous beam from the source-moderator via magnetic field will be discuss ed in detail. The plan for the trapping and injection of the positron will be presented. Moreover\, we will discuss the tests for a possible detecto r for Positronium inertial sensing\, which needs to have the capability of 3D reconstruction of the Ps annihilation point.\n[1] S. Mariazzi et al.\, Eur. Phys. J. D 74\, 79 (2020)\n[2] C. Amsler et al.\, Phys. Rev. A 99\, 033405 (2019)\n[3] S. Mariazzi et al.\, Phys. Rev. B 81\, 235418 (2010)\n[ 4] S. Mariazzi et al.\, Phys. Rev. Lett. 104\, 243401 (2010)\n[5] S. Maria zzi et al.\, J. Phys. B: At. Mol. Opt. Phys. 54\, 085004 (2021)\n[6] S. Ma riazzi et al.\, Phys. Rev B 105\, 115422 (2022)\n[7] A. P. Mills Jr. et al .\, Appl. Phys. Lett. 49\, 1121 (1986)\n[8] R. G. Greaves et al.\, NIM B 1 92 (2002)\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/733/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/733/ END:VEVENT BEGIN:VEVENT SUMMARY:Breast Cancer diagnosis study along with the introduction of new d etection technology DTSTART;VALUE=DATE-TIME:20220712T083900Z DTEND;VALUE=DATE-TIME:20220712T084100Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-745@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Shivani\; Jagiellonian University\, Poland (Jagiello nian University)\nAuthor: Shivani\n\nShivani1\,2 On the behalf of J-PET co llaboration\n1Faculty of Physics and Applied Computer Science\, Jagielloni an University\, Cracow\, Poland\n2Center for Theranostics\, Jagiellonian U niversity\, Poland\n\nIn both developing and developed countries\, breast cancer is the top cause of mortality among women. Medical imaging plays an important role for breast cancer screening\, for classifying and examinin g indistinct breast abnormalities\, as well as for defining the extent of breast tumors [1]. Positron Emission Mammography is one of the most widely used imaging modalities today (PEM). The goal of the J-PET group is to de velop\, build\, and test the J-PEM (Jagiellonian Positron Emission Tomogra phy)\, which is based on a novel concept using plastic scintillators[2\,3\ ,4\,5] and a wavelength shifter (WLS) [6\,7]. readout.\n\nThe results of t he examination of data acquired from the hospital\, which included 131 les ions\, will be presented in this poster. The cases involved 114 individual s\, with 98 having one lesion\, 14 having two lesions\, and one patient ha ving three lesions. The findings of the BI RADS-based diagnostic test will be presented. A comparison of ROC curves will also be shown.\nThe perform ance of a newly designed J-PEM scanner prototype is also characterised in this work. The goal of the J-PET group is to develop\, build\, and test th e J-PEM (Jagiellonian Positron Emission Tomography)\, which is based on a novel idea using plastic scintillators[2\,3\,4\,5] and wavelength shifter (WLS) [6\,7] readout. The prototype system is made up of two layers of pla stic scintillators (6x24x500 mm) and one layer of wavelength shifters [3] (3x10x100 mm) arranged orthogonally between them. For signal reading\, eac h scintillator bar is connected to Silicon Photomultipliers on both ends. This three-dimensional device is based on the innovative notion of using p lastic scintillators to detect annihilation photons and wavelength shifter s to improve spatial resolution (WLS). Gate simulation was used to calcula te the point spread function\, sensitivity\, and scatter fraction. To unde rstand the difference\, simulations were run with WLS strips (Z = 1.28 mm) and without WLS strips (Z = 10 mm). It is apparent that utilising WLS str ips lowered the value of PSF along the Z-axis by about half (4.7 mm).\n\n[ 1] E. Łuczyńska\,et al.\, Med Sci Monit\, 2015\; 21: 1358-1367\n[2] P. M oskal\, Sz. Niedźwiecki\, et al.\, Nucl. Instr. Meth. A 764\, 317 (2014). \n[3] P. Moskal\, O. Rundel\, et al.\, Phys. Med. Biol. 61\, 2025 (2016).\ n[4] P. Moskal\, K. Dulski\, et al.\, Science Advances 7 (2021) eabh4394.\ n[5] P. Moskal\, A. Gajos\, et al.\, Nature Communications 12 (2021) 5658. \n[6] J. Smyrski\, P. Moskal\, et al.\, BioAlgorithms and Med-Systems 10\, 59 (2014).\n[7] J. Smyrski\, et al.\, Nuclear Inst. and Methods in Physic s Research A 851\, 39-42\,\n(2017).\n\nAcknowledgements:\nThe authors ackn owledge support by the TEAM POIR.04.04.00-00-4204/17 program\, the NCN gra nt no. 2021/42/A/ST2/00423 and the SciMat and qLife Priority Research Area s budget under the program Excellence Initiative - Research University at the Jagiellonian University\n\nhttps://indico.koza.if.uj.edu.pl/event/7/co ntributions/745/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/745/ END:VEVENT BEGIN:VEVENT SUMMARY:Double photon coincidence detection method for gamma-ray imaging i n medicine DTSTART;VALUE=DATE-TIME:20220712T082300Z DTEND;VALUE=DATE-TIME:20220712T082500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-737@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Mizuki Uenomachi\; Kyoto University\, Japan ()\nAuth ors: Mizuki Uenomachi\, Kenji Shimazoe\, Hiroyuki Takahashi\n\nPositron em ission tomography (PET) utilizes the coincidence detection of annihilation gamma-rays with energy of 511 keV produced after a positron-electron coll ision. The positron position can only be constrained on a line connecting the detection points because two annihilation gamma-rays emit at the oppos ite direction. On the other hands\, some nuclides emit successive gamma-ra ys via an intermediate state with a short duration such as 111In\, 177Lu\, 60Co\, and so on. These successive gamma-rays are emitted at almost isotr opic direction\; thus\, the radionuclide location can be identified by usi ng direction-resolving radiation detection system. We have exemplified the position identification capability of double photon coincidence method by applying to Compton imaging and mechanical collimation-based gamma-ray im aging. Moreover\, we have demonstrated its crosstalk reduction capability in multi-nuclide Compton imaging. In the presentation\, we will show the e xperimental results of the double photon coincidence method application.\n \nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/737/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/737/ END:VEVENT BEGIN:VEVENT SUMMARY:Multiphoton time-of-flight MLEM reconstruction for the positronium imaging in J-PET DTSTART;VALUE=DATE-TIME:20220711T130000Z DTEND;VALUE=DATE-TIME:20220711T132000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-657@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Roman Shopa\; National Centre for Nuclear Research\, Poland ()\nWe modify the positronium imaging method for the Jagiellonian PET (J-PET) scanners\, using the simulated data for the decays of a metast able ortho-positronium (o-Ps) based on the pick-off and conversion process es resulting in two 511-keV annihilation photons [1\, 2]. An analytical mo del\, embedded into the time-of-flight maximum likelihood expectation maxi misation (TOF MLEM) reconstruction algorithm\, is introduced for the asses sment of the multiphoton detector response and the estimation of the o-Ps mean lifetime.\nThe detection probabilities of the J-PET system matrix are calculated for the coincident events each constituted by two annihilation and one deexcitation photons. TOF information is used for the iterative M LEM run and the estimation of a time difference between the annihilation a nd the positron emission\, the distribution of which is built for each vox el. The latter is updated in event-by-event way using the weights for the ultimate MLEM iteration.\nEmploying the Geant4 software [3]\, we simulated the experiments with four point-like sources put into two existing J-PET prototypes\, each corresponding to a tissue of a different o-Ps lifetime\, with total activity 1.1 MBq for the injected 22Na [2\, 4]. The decay mode l was restricted to include only the decays into back-to-back photons\, im plying the exponentially modified Gaussian shape for the aforementioned ti me difference histograms.\nUtilising TOF MLEM allowed to reduce the noise and significantly improve the spatial resolution of the positronium imagin g\, compared to the earlier studies [1\, 2]. The o-Ps mean lifetimes\, cal culated as a result of fitting the histograms exhibited a good consistency with the simulation setup. The reconstruction algorithm uses the advanced resolution model that accounts for both the geometrical factors and the d etector blur of the J-PET\, and can as well be extended to include attenua tion correction or other contributions\, as well as for the o-Ps decay int o three photons.\n\n[1] P. Moskal et al. “Performance assessment of the 2γ positronium imaging with the total-body PET scanners\,” EJNMMI Phys. \, vol. 7\, no. 44\, pp. 1\, Jun. 2020.\n[2] P. Moskal et al.\, “Positro nium imaging with the novel multiphoton PET scanner\,” Sci. Adv.\, vol. 7\, no. 42\, pp. 1\, Oct. 2021.\n[3] S. Agostinelli et al.\, “Geant4 – A Simulation Toolkit\,” Nucl. Instrum. Meth. A\, vol. 506\, no. 1\, pp. 250\, Jul. 2003.\n[4] P. Moskal et al.\, “Simulating NEMA characteristi cs of the modular total-body J-PET scanner – an economic total-body PET from plastic scintillators\,” Phys. Med. Biol.\, vol. 66\, no. 17\, pp. 175015\, Sep. 2021.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributi ons/657/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/657/ END:VEVENT BEGIN:VEVENT SUMMARY:Determination of 10B concentration in melanocytes and melanoma cel ls DTSTART;VALUE=DATE-TIME:20220712T084100Z DTEND;VALUE=DATE-TIME:20220712T084300Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-746@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Monika Szczepanek\; Jagiellonian University\, Poland ()\nAuthor: Monika Szczepanek\nCo-authors: Anna Telk\, Ewa Stępień \ n\nMelanoma is the most aggressive skin cancer\, difficult to treat when m etastatic. It is also cancer that may become a candidate for Boron Neutron Capture Therapy (BNCT). BNCT is type of radiation therapy that employ the altered metabolism of cancer cells and additionally minimizes side effect s. During treatment\, the patient is administered a compound containing th e non-radioactive isotope of boron (10B)\, which accumulates in the melano ma cells due to its increased metabolism compared to normal cells [1]. The n\, the diseased area of the patient's body is irradiated with a thermal n eutron beam. As a result of irradiation\, cells with accumulated 10B are d estroyed\, while neighboring cells\, not loaded with 10B stayed undamaged. Selectivity in this therapy is based on the increased metabolism of neopl astic cells\, which ensures a higher boron concentration compared to norma l cells [2\,3]. The principle of efficient BNCT depends on the amount of b oron delivered to cancer cells \, which must be 3 times higher in compare to normal cells. Therefore\, the aim of proposed research is to assess the uptake of the 10B isotope by normal and cancer cells in an 2D in vitro mo del.\nIn our research\, we used normal skin cells – melanocytes and two melanoma cell lines\, delivered from primary tumor (WM115) and metastasis (WM266-4). Cells were incubated with boron carrier (boronophenylalanine\, BPA) in concentration 50 µg B/ mL\, for 2\, 4\, 6 and 12 hours. The effec tive boron carrier ensures a high concentration of 10B atoms in the cells at the level of 20-35 µg10B / g of tumor tissue ( 1.2-2.1x109 10B atoms p er cell) [4]. After incubation cells were harvested and 10B isotope concen tration was measured using inductively coupled plasma mass spectrometry (I CP-MS).\nBoth melanoma cell lines reached maximum concentration of 10B aft er 4h of incubation with BPA\, 9\,2 µg10B/g and 27\, 9 µg10B/g for WM115 and WM266-4\, respectively and these concentrations seemed to fluctuate w ithin 12 hours of incubation. In case of melanocytes 10B concentration in cells increased during the incubation time up to reach the highest boron c oncentration at 33\,7 µg10B/g in 12 hour of incubation.\nOur results show ed different kinetics of boron uptake in different cell types which is in confirms previous studies [5]. These data suggest the need to investigate the mechanism of BPA uptake and metabolism in other melanoma cell lines to eligible BPA for BNCT cancer treatment.\nReferences:\n[1] Mishima Y\, Hon da C\, Ichihashi M\, Obara H\, Hiratsuka J\, Fukuda H\, et al. Treatment o f malignant melanoma by single thermal neutron capture therapy with melano ma-seeking 10B-compound. Lancet. 1989\;2:388–389.\n[2] Nedunchezhian K\, Aswath N\, Thiruppathy M\, Thirugnanamurthy S. Boron Neutron Capture Ther apy - A Literature Review. J Clin Diagn Res.2016\;10:ZE01-04.\n[3] Silarsk i M\, Dziedzic-Kocurek K\, Szczepanek M. Combined BNCT and PET for therano stics. BAMS. 2021\;17:293-300.\n[4] Verlinden B\, Van Hoeckeet K\, Aertsal A\, Daems N\, Dobney A\, Janssens K\, et al. Quantification of boron in c ells for evaluation of drug agents used in boron neutron capture therapy. JAAS. 2021\;36:598-606 .\n[5] Carpano M\, Perona M\, Rodriguez C\, Nievase t S\, Olivera M\, Santa Cruz G.A\, al. Experimental Studies of Boronopheny lalanine (10BPA) Biodistribution for the Individual Application of Boron N eutron Capture Therapy (BNCT) for Malignant Melanoma Treatment Int. J. Rad iat. Oncol. Biol. Phys. 2015\;93:344-352.\nAcknowledgments:\nThis work was supported by the SciMat Priority Research Area budget under the Strategic Programme Excellence Initiative at the Jagiellonian University through gr ant No. U1U/P05/NO/03.47.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/cont ributions/746/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/746/ END:VEVENT BEGIN:VEVENT SUMMARY:Intelligent data analysis for the next generation medical phantom Dose-3D DTSTART;VALUE=DATE-TIME:20220712T082500Z DTEND;VALUE=DATE-TIME:20220712T082700Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-738@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kamila Kalecińska\; AGH University of Science and T echnology\, Poland ()\nAuthors: Kamila Kalecińska\, Dose-3D Collaboration \n\nMedical data intelligent analysis is the part of TEAM NET \nDose3D Pro ject “A Reconfigurable Detector for Measuring the Spatial Distribution o f Radiation Dose for Applications in the Preparation of Individual Patient Treatment Plans”. The goal of the Dose3D consortium is to build a three -dimensional measurement system containing a detector capable of directly measuring the spatial distribution of the deposited therapeutic dose in re al-time. The keyword “reconfigurable” means that such a tissue-like ph antom can be configured to mimic a specific part of the patient 's body. D elivery of a proper geometry which is in the form of 3D Computed Tomograph y (CT) scans of the patient body with highly precise delineation of the ar ea of affection to the detector is the important step of the whole process . The idea is to build a reliable\, fully automatic tool that would be abl e to extract the desired volume from 3D CT images. Technically this proces s (named segmentation) refers to assigning each voxel of the 3D image to a specific class.\nTraining data for segmentation tasks consists of raw CT scans in DICOM format as well as already manually segmented data in DICOM- RT Structures format. Medical data format complexity and data limitations mostly caused by privacy issues that require the preparation of a special preprocessing pipeline. One of the important steps in this procedure is to perform an effective data augmentation\, which refers to artificially inc reasing the amount of training data. Both data augmentation and 3D image a utomatic segmentation tools will be built on the basis of the most advance d deep learning models.\nHigh computational power and GPU’s support are required in the process of training 3D deep learning models. Fortunately\, the modern platform delivered by NVIDIA (NVIDIA Clara) with Python framew ork MONAI is dedicated to healthcare data analysis. This framework provide s state-of-the-art pre-trained ML models\, a set of tools for medical prep rocessing and domain-specific GPU optimization.\nThe presentation will be about prospects\, challenges and the current stage of developing medical d ata analysis tools with the potential to improve the individual treatment plans.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/738/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/738/ END:VEVENT BEGIN:VEVENT SUMMARY:Study of positronium in normal and cancer cells DTSTART;VALUE=DATE-TIME:20220711T132000Z DTEND;VALUE=DATE-TIME:20220711T134000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-659@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Ewelina Kubicz-Staszkiewicz\; Jagiellonian Universit y\, Poland ()\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/659/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/659/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Sensitivity of the deeply bound pionic atoms to the pion-nucleon sigma term DTSTART;VALUE=DATE-TIME:20220712T132000Z DTEND;VALUE=DATE-TIME:20220712T134000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-674@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Natsumi Ikeno\; Tottori University\, Japan ()\nThe d eeply bound pionic atom is known to be a very useful system to investigate the pion properties and the aspects of chiral symmetry at finite density. The pion-nucleon sigma term σπN is one of the essential quantities to i nvestigate the value of the chiral condensate in the nuclear medium. Howev er\, the σπN value has not been determined accurately enough. Therefore\ , it seems to be very interesting to determine the σπN value by the deep ly bound pionic atoms.\n\nWe have theoretically studied the sensitivity of the observables of the deeply bound pionic atoms to the pion-nucleon sigm a term σπN to investigate the possibility of the precise determination o f the value of σπN by the accurate data of the deeply bound pionic atoms expected to be obtained at RIBF/RIKEN. I will give a presentation based o n the paper of Ref. [1].\n\n[1] N. Ikeno\, T. Nishi\, K. Itahashi\, N. Nos e-Togawa\, A. Tani and S. Hirenzaki\, arXiv:2204.09211 [nucl-th].\n\nhttps ://indico.koza.if.uj.edu.pl/event/7/contributions/674/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/674/ END:VEVENT BEGIN:VEVENT SUMMARY:Study of differences in the composition of glycosphingolipids betw een the extracellular vesicles from β-cell and endothelium cell lines usi ng ToF-SIMS DTSTART;VALUE=DATE-TIME:20220712T084500Z DTEND;VALUE=DATE-TIME:20220712T084700Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-748@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Magdalena Marzec\; Jagiellonian University\, Poland ()\nAuthor: Dr Magdalena Marzec\nCo-authors: Carina Rząca\, Ewa Stepien\n \nTime of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is used to ana lyze biomolecules in tissues\, cells and membranous structures. This type of mass spectrometry enables qualitative semi-native testing without the n eed for isolation\, fixation or labelling of target elements with simultan eous 2D imaging. The analyzed mass range is less than 1000 Da\, which make s it possible to study of amino acids and lipids [1]. Extracellular vesicl es (EVs) are spherical cellular structures surrounded by a lipid bilayer i n size from 30 to 1000 nm. The basic classification of EVs distinguishes t hree subpopulations: exosomes derived from endosomes (50–150 nm)\, cell ectosomes (100–1000 nm) and apoptotic bodies (1000–5000 nm). Due to th e constantly growing importance of EVs in the diagnosis and treatment of d iseases\, more and more attempts are made to effectively isolate\, detect and analyze them [2]. So far\, it has not been demonstrated whether the in creased sugar concentration in the external environment modifies the compo sition of glycosphingolipids (GSL) in the composition of cell membranes an d EVs.\nThe aim of the study is to compare the GSL composition in EV subpo pulations: ectosomes and exosomes. In this study\, EVs were purified by a low-pressure filtration and concentrated by an ultracentrifugation. EVs co me from two cell lines: pancreatic β-cells and microvascular endothelium cells (TIME). Both cell lines were grown under normoglycemic (NG) and hype rglycemic (HG) conditions. The experiment also investigated the change in the content of the analyzed biomolecules in EVs due to high glucose concen tration influence.\nAs a result of the conducted research\, we have shown that we can perform glycosphingolipid analysis in extracellular vesicles u sing ToF-SIMS. The analysis showed significant changes in GSL composition depending on the cell line (β-cells and microvascular endothelium cells) for both ectosome and exosome populations. Cell culture conditions (hyperg lycemia) affect the glycosphingolipids profile both in the group of ectoso mes and exosomes.\n\nReferences:\n[1] M.E. Marzec\, D. Wojtysiak\, K. Poł towicz\, J. Nowak\, R. Pedrys\, Study of cholesterol and vitamin E levels in broiler meat from different feeding regimens by TOF-SIMS\, Biointerphas es. 11 (2016). https://doi.org/10.1116/1.4943619.\n[2] A. Kamińska\, M. R oman\, A. Wróbel\, A. Gala-Błądzińska\, M.T. Małecki\, C. Paluszkiewi cz\, E.Ł. Stępień\, Raman spectroscopy of urinary extracellular vesicle s to stratify patients with chronic kidney disease in type 2 diabetes\, Na nomedicine Nanotechnology\, Biol. Med. 39 (2022) 102468. https://doi.org/h ttps://doi.org/10.1016/j.nano.2021.102468.\n\nAcknowledgements\nThis work has been funded from the SciMat and qLife Priority Research Area budget un der the Strategic Programme Excellence Initiative at the Jagiellonian Univ ersity and by the National Science Center (NCN)\, grant OPUS 17 to prof. E . Stępień (No. 2019/33/B/NZ3/01004).\n\nhttps://indico.koza.if.uj.edu.pl /event/7/contributions/748/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/748/ END:VEVENT BEGIN:VEVENT SUMMARY:Current progress\, challenges and frontiers for Ps-based oncology nanodiagnostics DTSTART;VALUE=DATE-TIME:20220711T134000Z DTEND;VALUE=DATE-TIME:20220711T140000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-660@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Bożena Zgardzińska\; Maria Curie-Sklodowska Univer sity\, Poland ()\nPublication agreement (CC BY 4.0) Yes\nPrimary authors\ nBożena Zgardzińska (Institute of Physics\, Maria Curie-Sklodowska Unive rsity) Dr Jerzy Mielko (Department of Surgical Oncology\, Medical Universi ty of Lublin) Ms Katarzyna Gęca (Department of Surgical Oncology\, Medica l University of Lublin) Marek Gorgol (Maria Curie-Sklodowska University\, Institute of Physics\, Department of Nuclear Methods\, Pl. M. Curie-Sklodo wskiej 1\, 20-031 Lublin\, Poland) Radek Zaleski (Maria Curie-Skłodowska University) Magdalena Goździuk (Maria Curie- Sklodowska University) Boże na Jasińska (Institute of Physics\, Maria Curie Sklodowska University) Dr Stephenson Owusu (Radiation Research Laboratory\, University of Notre Dam e) Dr Gustaw Chołubek (Diagnostic Techniques Unit\, Faculty of Health Sci ences\, Medical University of Lublin) Mr Konrad Wysogląd (Institute of Ph ysics\, Maria Curie-Sklodowska University) Katsiaryna Yankova\nPresentatio n Materials\nThere are no materials yet.\n\nhttps://indico.koza.if.uj.edu. pl/event/7/contributions/660/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/660/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Study of the eta-prime meson in nuclei in the LEPS2/ BGOegg experiment DTSTART;VALUE=DATE-TIME:20220712T141000Z DTEND;VALUE=DATE-TIME:20220712T143000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-675@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Natsuki Tomida\; Kyoto University\, Japan ()\nA larg e mass reduction of the η′(958) in nuclei is expected in several theore tical models. If there is large mass reduction\, an η′ meson and a nucl eus can form a bound state. We investigated the η′-nucleus system in th e LEPS2/BGOegg experiment. To search for the η′-nucleus bound state\, w e carried out the missing mass spectroscopy of the 12C(γ\,p) reaction. To suppress background events from mult-meson productions\, the one nucleon absorption decay products were simultaneously measured for the first time. In addition\, we also carried out the simultaneous measurement of escapin g η′ mesons from nuclei. We will report the η′-nucleus optical poten tial evaluated by using both data. We will also show the preliminary resul ts of the direct measurement of η′ mass spectra from the η′→γγ d ecay in nuclei.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/ 675/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/675/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Studying the process γd→π0ηd DTSTART;VALUE=DATE-TIME:20220712T145000Z DTEND;VALUE=DATE-TIME:20220712T151000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-677@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Alberto Martinez Torres\; University of Sao Paulo\, Brasil ()\nIn this talk I will present a theoretical study of the γd→π 0ηd reaction and show that the observed shift of the peaks of the π0d\, ηd invariant mass distributions with respect to the phase space distribut ions are related to the dynamics of the γp→π0ηp.\n\nhttps://indico.ko za.if.uj.edu.pl/event/7/contributions/677/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/677/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Mass modifications of vector mesons in a finite dens ity matter DTSTART;VALUE=DATE-TIME:20220712T143000Z DTEND;VALUE=DATE-TIME:20220712T145000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-676@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kyoichiro Ozawa\; Institute of Particle and Nuclear Studies\, KEK\, Japan ()\nOrigin of hadron masses have wide interests in t he field of nuclear physics. Light quarks\, such as up and down quarks\, o nly have “bare” mass of a few MeV/c^2. A proton and a neutron\, which contains only three quarks\, have mass of ~1 GeV/c^2. This difference betw een quark mass and hadron mass can be theoretically explained as dynamical generations of hadron mass by a spontaneous breaking of a symmetry in a “QCD vacuum”. In this point of view\, hadron masses are not a stable a nd it can be changed in a finite temperature and/or density medium. Severa l experimental efforts are performed to measure mass modifications of hadr ons in a finite temperature and/or density medium. In high temperature reg ion\, high energy heavy ion experiments\, such as SPS\, RHIC\, LHC\, are p erformed. Experiments at KEK-PS\, CLAS\, CBELSA/TAPS are also performed to study hadron masses in a nucleus\, as a finite density matter.\nWe are ca rrying out a new experiment to measure mass spectra of vector mesons in nu clei at J-PARC in Japan. The experiment is a successor to the experiment a t KEK-PS. In the experiment\, we measure electron-positron decays of vecto r mesons\, since mass spectra of the vector mesons have strong relations w ith an order parameter of the symmetry breaking in the medium. We focus on electron-positron decays to avoid final state interactions between medium and daughter particles. We constructed new spectrometer which consists of four layers of tracking detectors and two kinds of electron identificatio n counters. Tracking detectors are one layer of Silicon Strip Detector and three layers of Gas Electron Multiplier (GEM) Trackers. For electron iden tifications\, GEM-based gas Cherenkov counters\, so called Hadron Blind De tector\, and Lead Glass EM calorimeters are used.\nWe started construction s of a beam line and detectors in 2012. We had the first beam in 2020 and started beam study and detector shake down. We collected pilot data in 202 0 and 2021 to evaluate detector performances. We are planning to have the first physics data-taking period in early 2023. We will introduce recent a ctivities of related studies and show status of our experiment.\nAlso\, fu ture plans to measure mass modification in a high-density matter which can be created using heavy ion collisions will be discussed.\n\nhttps://indic o.koza.if.uj.edu.pl/event/7/contributions/676/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/676/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Pionic atoms and chiral symmetry DTSTART;VALUE=DATE-TIME:20220711T143000Z DTEND;VALUE=DATE-TIME:20220711T145000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-661@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kenta Itahashi\; RIKEN\, Japan ()\nWe have been work ing on pionic atoms to extract information\non the chiral symmetry of the vacuum at the nuclear density.\nIn the recent analysis\, we evaluated the chiral condensate\nat the normal nuclear density (arXiv: 2204.05568). In 2 021\,\nwe have conducted a new systematic measurement of pionic\natoms alo ng the long chain of the Sn nuclei. I will report the\nrecent progress and the future perspectives.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/cont ributions/661/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/661/ END:VEVENT BEGIN:VEVENT SUMMARY:Detection of concentration and survival of HL-60 human acute promy elocytic leukemia cells by the PALS technique DTSTART;VALUE=DATE-TIME:20220712T084300Z DTEND;VALUE=DATE-TIME:20220712T084500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-747@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Katsiaryna Yankova\; Maria Curie-Skłodowska Univers ity\, Poland ()\nAuthor: Katsiaryna Yankova\nCo-authors: Bożena Zgardziń ska\, Bożena Jasińska\, Marek Gorgol\, Marcin Czop\, Janusz Kocki\n\nThe HL-60 human acute promyelocytic leukemia cells obtained from the Clinical Genetics Department of Medical University in Lublin were investigated wit h the use of positron and positronium probes. The HL-60 cell line is a pop ular and convenient test object due to easy reproduction. The cell line co mes from the patient\, 36-year-old Caucasian female with acute promyelocyt ic leukemia. The 16 samples were used for the study: 15 with HL-60 cell-li ne with different concentration of cells and 1 sample with a pure medium\, as a reference. The studies were performed with positron annihilation lif etime spectroscopy (PALS) and the results were correlated with cell surviv al. Examined samples were subjected to various external factors during mea surements: ionizing radiation\, time and light.\nIn contrast to our expect ations\, we found that the o-Ps component in PALS spectra does not differe ntiate the samples sufficiently and can’t be used as the only analyzed p arameter. The components of para-positronium and free annihilation should also be considered. Our studies indicate the possibility of assessing the concentration of cell lines using the PALS technique\, but a much more imp ortant factor differentiating the obtained results turned out to be the co ncentration of live cells in the sample. The positron annihilation shows a very close correlation with viability of the cells in the samples. Relayi ng on gathered information we can conclude that the PALS technique can be used as a highly sensitive method for estimating the quantity of living ce lls in sample.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/7 47/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/747/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Alpha and cluster decay of thermally excited nuclei DTSTART;VALUE=DATE-TIME:20220711T145000Z DTEND;VALUE=DATE-TIME:20220711T151000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-662@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Neelima Kelkar\; University of los Andes\, Colombia ()\nThe unprecedented observational data from compact object mergers in re cent years have confirmed that the nucleosynthesis of heavy and super heav y nuclei can be considered to proceed via the rapid neutron capture or r-p rocess. The r-process nucleosynthesis path is along highly unstable\, exot ic\, and neutron-rich nuclei. Thus\, it is not only the photo-dissociation and neutron capture cross sections but also fission (spontaneous and indu ced) and the decay rates which are important for the abundance evolution.\ nThe explosive conditions in supernovae and neutron star mergers leading t o considerably high temperatures could result in nuclei existing in excite d states. Though the thermal excitations of nuclei are usually taken into account in the production reactions and their reverse reaction rates\nente ring the network calculations\, the alpha decay rates are taken to be thos e corresponding to the terrestrial decays of ground state nuclei.\nIn this talk\, we shall discuss the effects of thermal excitations on the half-li ves of heavy nuclei which decay by emitting an alpha particle (4He) or lig ht clusters such as 14C\, 20O\, 28Mg etc.\n\nhttps://indico.koza.if.uj.edu .pl/event/7/contributions/662/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/662/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Exotic properties of N*(1895) and its impact on phot ophroduction of light hyperons DTSTART;VALUE=DATE-TIME:20220712T151000Z DTEND;VALUE=DATE-TIME:20220712T153000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-678@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kanchan Khemchandani\; Federal University of Sao Pau lo\, Brasil ()\nIn a recent work\, we have studied the decay properties of N(1895)\, which was found to arise from meson-baryon interactions in an e arlier work. We investigate the decays to different meson-baryon systems a nd to final states involving \\Lambda(1405) and a proposed \\Sigma(1400). In this talk\, I will show that the width of N^(1895) can get an important contributions from the decay to light hyperon resonances and such finding s can be relevant for processes like the photoproduction of \\Lambda(1405) .\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/678/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/678/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Nuclear instabilities in white dwarfs DTSTART;VALUE=DATE-TIME:20220711T151000Z DTEND;VALUE=DATE-TIME:20220711T153000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-663@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Marek Nowakowski\; University of los Andes\, Colombi a ()\nA special class of white dwarfs violating the standard Chandrasekhar limit are right now a timely topic. These Super-Chandrasekhar objects cou ld be understood as the progenitor of supernovae type Ia (SN Ia) and this is the main reason for their astrophysical interest. Some early studies ta ckled the possibility of white dwarfs surpassing the Chandrasekhar limit b y means of magnetic fields. More recently modified gravity has turned out to be a new possibility that the researchers have discovered. In such a se tting however\, the theory becomes more sensitive to the the nuclear insta bilities at the center of the star and a rigorous treatment of the latter becomes obligatory. In this talk we shall discuss the problem with a reali stic equation of state to describe the white dwarfs in modified gravity ta king into account the nuclear instabilities. A reliable limit of the maxim um mass can be reached and put to test.\n\nhttps://indico.koza.if.uj.edu.p l/event/7/contributions/663/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/663/ END:VEVENT BEGIN:VEVENT SUMMARY:Assessment of the influence of the Beta parameter in the reconstru ction of Q.Clear DTSTART;VALUE=DATE-TIME:20220712T085100Z DTEND;VALUE=DATE-TIME:20220712T085300Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-771@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Konrad Skórkiewicz\; Jagiellonian University\, Pola nd ()\nAuthor: Konrad Skórkiewicz\nCo-authors: Anna Sowa-Staszczak\, Kazi mierz Łątka\n\nAim/Introduction: The aim of the study is to determine th e appropriate value of the β parameter using the Q.Clear reconstruction a lgorithm in the imaging of patients with neuroendocrine tumors. Materials and Methods: The analysis concerned the measurements of the NEMA IEC Body Phantom\, filled with Ga-68 gallium chloride. Within the phantom we placed the 4 smalles hot spheres filled with a higher isotope concentration in c omparison with the body part. Imaging was performed in the PET/CT scanner in few time intervals. The raw data were reconstructed with the use of the Q.Clear reconstruction algorithm with 18 values of the β parameter (150- 1000\, every 50). Results: The obtained results show that together with an increase of the values of the β parameter\, the image quality in the Q.C lear reconstruction algorithm increases. Referring to the scientific repor ts\, one can see that the signal to noise ratio in the image increases. Th e effect of the change of the β parameter on the SUV mean value is the la rgest for the smallest sphere. The percentage decrease is much higher also with the lower values of the activity\, reaching a value of 3.7% and 8.5% for large and small sphere with β=450\, in comparison with β=200. With β=1000 a very significant decrease is observed\, especially for the small est sphere and for the lowest activity measured\, which is 18.5 % when β= 200. Conclusion: An increase of the values of the β parameter has an adve rse effect on the quantitative assessment of SUV. In the visual assessment \, a satisfactory image quality is present with β=450. This value results in a relatively low decrease of the SUV mean and SUV max.\n\nhttps://indi co.koza.if.uj.edu.pl/event/7/contributions/771/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/771/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: New developments and human imaging experience with t he PennPET Explorer DTSTART;VALUE=DATE-TIME:20220713T070000Z DTEND;VALUE=DATE-TIME:20220713T072500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-681@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Suleman Surti\; University of Pennsylvania\, USA ()\ nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/681/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/681/ END:VEVENT BEGIN:VEVENT SUMMARY:Decay probabilities in the multichannel case DTSTART;VALUE=DATE-TIME:20220711T153000Z DTEND;VALUE=DATE-TIME:20220711T155000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-664@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Francesco Giacosa\; Jan Kochanowski University of Ki elce\, Poland ()\nIn the context of an unstable state with more than a sin gle decay channel\, we present a novel and general formula for evaluating the decay probabilities in each open decay mode. We also discuss numerical examples in Quantum Mechanics (QM) and Quantum Field Theory (QFT). Just a s for the survival probability p(t)\, these partial decay probabilities ar e also not exponential and their ratio turns out to be not a simple consta nt\, as it would be in the exponential limit. Quite remarkably\, these dev iations may last relatively long\, thus making them potentially interestin g in applications.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributio ns/664/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/664/ END:VEVENT BEGIN:VEVENT SUMMARY:Opening talk: Potential Applications of Total Body PET Imaging wit h Emphasis on CV\, MSK and Malignant Disorders DTSTART;VALUE=DATE-TIME:20220711T070000Z DTEND;VALUE=DATE-TIME:20220711T074500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-577@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Abass Alavi\; University of Pennsylvania\, USA ()\nT he introduction of X-Ray by Roentgen in 1895 started a major revolution in medicine and still continues to have an impact on its current practice on a daily basis. However\, no major\, physics-based invention was initiated until the 1960s when David Kuhl at the University of Pennsylvania (Penn) introduced the concept of tomography as we know today. He and his colleagu es were first to design an instrument that allowed radiation-based imaging of brain tumors by a technique that was called “emission tomography” at the time. The invention of Computed Tomography (CT) by Hounsfield in 19 71 added a major dimension to modern imaging armamentarium. While prototyp e CT imaging was somewhat complicated and limited in scope\, over the past 5 decades\, this very powerful imaging modality has matured significantly and is nowadays the workhorse of clinical practice of medicine. The intro duction of the concept of MRI in 1970s by Lauterbur added a major dimensio n to medical imaging and its role in complicated diseases and disorders.\n \nInitial applications of emission tomography were primarily focused on as sessing blood-brain barrier abnormalities by conventional radiotracers. Ho wever\, the significant superiority of contrast enhanced CT over emission tomography propelled investigators at Penn to introduce the concept of ass essing brain glucose metabolism by radiolabeled deoxyglucose. Efforts at P enn soon led to synthesizing 18F-Fluorodeoxyglucose (FDG) and the first hu man studies were performed in August 1976. The success of this effort was a major stimulus to mobilizing forces for practical applications of positr on emitting radiopharmaceuticals for both research and clinical purposes. Investigators at Washington University\, led by Michael Ter-Pegossian\, de signed and built prototype positron emission tomography (PET) instruments that further enhanced the role of the modality in many settings. Over the years\, significant advances have been made in designing CT\, MRI\, and PE T imaging which has improved practical applications of such instruments. I n 2000\, the first hybrid PET/CT instrument was introduced by investigator s at the University of Pittsburgh\, and this allowed combining molecular i mages acquired by PET with those of CT. During the past 10 years\, PET/MRI instruments have further enhanced our ability to combine the advantages o f these two powerful modalities as a single powerful unit.\n\nDuring the p ast several years\, investigators at University of California\, Davis and United Imaging in Shanghai have designed and built total body PET/CT instr uments for simultaneous imaging of the entire body with a single acquisiti on. Similar approaches have been adopted by investigates at Penn\, the Uni versity of Kraków\, and Siemens which is further enhancing the role of th is approach worldwide.\n\nOver the past few decades\, molecular imaging wi th PET has made a major impact in many domains in medicine. While initial interests were focused on brain imaging because of the\n\nlimitations of a vailable instruments during the early years of PET technology\, the introd uction of body imaging has expanded interests into imaging various maligna ncies\, cardiovascular disorders\, and many infectious/inflammatory diseas es. The application of PET to the day-to-day practice of medicine has subs tantially improved patient care in many disciplines including neurology\, oncology\, orthopedics\, and other disorders of mankind. These approaches have substantially influenced management of patients and avoiding unnecess ary and costly procedures. Because of the success of FDG\, many new tracer s have been introduced over the years that have shown great promise in ass essment of both benign and malignant abnormalities. The ability for succes sful quantification by PET has also made a major contribution to the succe ss of this modality. During the past few decades\, great interest of globa l disease assessment by the medical imaging for many systemic disorders ha s become a reality employing conventional PET instruments with a limited f ield of view. This approach provides a single number that represents disea se activity throughout the body and has significant implications for optim al management of the affected population. Therefore\, the ability to image the entire body with total body PET instruments combined with such quanti tative capabilities will have far reaching impact in the future. In convul sion\, the revolution that has evolved over the past 5 decades in medical imaging is unparalleled in any discipline in medicine and this will lead t o substantially improved patient care in the future worldwide.\n\nhttps:// indico.koza.if.uj.edu.pl/event/7/contributions/577/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/577/ END:VEVENT BEGIN:VEVENT SUMMARY:Gold nanoparticles as contrast agents for micro-CT imaging DTSTART;VALUE=DATE-TIME:20220712T084700Z DTEND;VALUE=DATE-TIME:20220712T084900Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-755@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Dominik Panek\; Jagiellonian University\, Poland ()\ nAuthors: Dominik Panek\, Monika Szczepanek\nCo-authors: Bartosz Leszczyń ski\, Paweł Moskal\, Ewa Stępień\n\nMicro-computed tomography (micro-CT ) is nowadays often used to examine biological samples. This technique\, b ased on the attenuation of X-rays\, is capable of achieving micrometric re solution. However\, the challenge is to stain the samples in such a way th at they will be opaque to the X-ray radiation with a given energy. That is why different types of contrast agents are being currently developed in o rder to obtain the highest contrast. But the contrast itself is often not enough for the biological studies. It is also important for the contrastin g agent not to be toxic in any way – it has to be biocompatible. Example of such contrasting agents are gold nanoparticles (AuNPs)\, which are by far the most studied nanomaterials and\, amongst other metallic nanopartic les\, are believed to be the most appropriate for biological research [1\, 2]. In our studies\, the CT scanner (SkyScan 1127) was used in order t o visualize the uptake and accumulation of AuNPs. The nanoparticles were i ncubated with melanoma cell line (WM266-4) spheroids – a 3D cell model o f cell culture intended to imitate tumor tissue\, especially the environme nt inside it [3]. In this case\, micro-CT was used to check if it is possi ble to visualize AuNPs inside spheroids created from a the same number of cells (2000) and on different days of growth (3rd and 7th)\, incubated for 24h. The concentration of gold NPs used in this study was identical for a ll the samples and equal to 2.5 µg/ml. Additioanlly\, the same concentrat ion of AuNPs was added to the cells from the beginig of spheroid creation to comapre it with standard method. The results of experiments indicate th at AuNPs are promising contrast agents\, due to their high atomic numer\, which does not require the use of high concentraions. The spheroid was not created in case of the method where AuNPs were added to the cells from th e beginning.\nReferences\n[1] Kus-Liśkiewicz M\, et al. Biocompatibility and Cytotoxicity of Gold Nanoparticles: Recent Advances in Methodologies a nd Regulations. Int J Mol Sci. 2021\;22(20):10952.\n[2] Karimi\, H.\, Lesz czyński\, et al.\, X-ray microtomography as a new approach for imaging an d analysis of tumor spheroids. Micron\, 137.\n[3] Stępień\, E.\, Karimi\ , H.\, Leszczyński\, B.\, & Szczepanek\, M. (2020). Melanoma spheroids as a model for cancer imaging study. Acta Physica Polonica. B\, 51(1)\, 159 –163.\nAcknowledgements\nThe authors acknowledge support by the TEAM POI R.04.04.00-00-4204/17 program and the SciMat and qLife Priority Research A reas budget under the program Excellence Initiative - Research University at the Jagiellonian University and by DSC grant\, no. N17/MNS/000058/2021\ , awarded to D. Panek funded by Jagiellonian University.\n\nhttps://indico .koza.if.uj.edu.pl/event/7/contributions/755/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/755/ END:VEVENT BEGIN:VEVENT SUMMARY:Characterization of the 192-strip J-PET detector for multi-photon positronium imaging DTSTART;VALUE=DATE-TIME:20220712T085700Z DTEND;VALUE=DATE-TIME:20220712T085900Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-775@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kamil Dulski\; Jagiellonian University\, Poland ()\n Author: K. Dulski on behalf of the J-PET collaboration\n\nPositronium imag ing is a promising new technique that can enhance the diagnostic capabilit ies of Positron Emission Tomography (PET)\, based on a new structural inde x derived from ortho-positronium interaction with the environment in which it annihilates [1\,2]. A positronium (Ps) can be formed during a standard PET scan when a positron emitted from a radiopharmaceutical administered to a patient forms a bound state with the electron. Depending on the total spin number S\, the positronium can be formed in one of two states - para -Ps (p-Ps\, S = 0) and ortho-Ps (o-Ps\, S = 1). These two states differ ma inly in the average lifetime (in vacuum: 0.125 ns for p-Ps and 142 ns for o-Ps) and the number of photons that are emitted during the annihilation ( p-Ps even\, o-Ps odd number of photons). In particular\, the lifetime of o -Ps may be shortened when interacting with the environment in which it is formed. Therefore\, by simultaneously reconstruction of the position of o- Ps annihilation and its average lifetime\, it becomes possible to characte rize the structure of a given part of the sample in space\, which is the b asis for positronium imaging [1]. Currently\, the J-PET detector [1-3] is the only detector that is able to obtain positronium images. The positroni um images of the two phantoms measured by the 192-strip J-PET detector wil l be shown [1\,4]. Additionally\, data on the sensitivity and purity of tw o- and three-photon positronium imaging will be presented on the basis of simulation data [4].\n[1] P. Moskal\, K. Dulski\, N. Chug et al.\, Positro nium imaging with the novel multiphoton PET scanner\, Science Advances 7 ( 2021) eabh4394\n[2] P. Moskal and E.Ł. Stępień\, Positronium as a bioma rker of hypoxia\, Bio-Aglorithms and Med-Systems 17 (2021) 311-319\n[3] P. Moskal\, S. Niedźwiecki\, T. Bednarski et al.\, Test of a single module of the J-PET scanner based on plastic scintillators. Nucl. Instr. and Meth . A 764\, 317-321 (2014)\n[4] K. Dulski\, PhD Thesis: Development of posit ronium imaging with the 192-strip J-PET detector (2022)\n\nhttps://indico. koza.if.uj.edu.pl/event/7/contributions/775/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/775/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: Clinical and Technical Consideration for Fast TOF PET DTSTART;VALUE=DATE-TIME:20220711T074500Z DTEND;VALUE=DATE-TIME:20220711T081000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-578@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Georges El Fakhri\, Gordon Center\, Massachusetts Ge neral Hospital\, Harvard Medical School\, USA ()\nG. El Fakhria\, J. Álam o i\, J. Barberái\, J.M. Benllochi\, G. Borghib\, R. Dolenecc\,d\, J. M. Fernández-Tenlladoe\, D. Gascóne\, S. Gómezf\,e\, A. Golab\, K. Grogga\ , D. Gubermane\, S. Korparg\,d\, P. Križanc\,d\, S. Majewskih\, R. Manera e\, T. Marina\, A. Mariscal-Castillae\, J. Mauricioe\, S. Merzib\, C. More ra i\, M. Oreharc\, G. Pavóni M. Pennab\, R. Pestotnikd\, G. Razdevšekc \, H. Sabetha\, A. Seljakd\, A. Studenc\,d\n\naGordon Center for Medical I maging and Harvard Medical School\, Boston\, MA 02114\, United States\,\nb Fondazione Bruno Kessler\, 38123 Povo TN\, Italy\,\ncFaculty of Mathematic s and Physics\, University of Ljubljana\, Ljubljana\, Slovenia\,\ndJožef Stefan Institute\, Ljubljana\, Slovenia\,\neDept. Física Quàntica i Astr ofísica\, Institut de Ciències Del Cosmos (ICCUB)\, University of Barcel ona (IEEC-UB)\, Barcelona\, Spain\,\nfSerra Húnter Fellow\, Polytechnic U niversity of Catalonia (UPC)\, Barcelona\, Spain\,\ngFaculty of Chemistry and Chemical Engineering\, University of Maribor\, Maribor\, Slovenia\,\nh University of California Davis\, Davis\, CA 9b616\, United States of Ameri ca\, \niOncovision\, Valencia\, Spain\n\nThe paradigm shift in medicine fr om treatment of acute and/or advanced disease to very early diagnosis and even prevention in cancer\, neurodegenerative as well as cardiac fields\, puts more stringent requirements on PET imaging both in terms of sensitivi ty as well as specificity. Likewise\, recent developments in Targeted Rad ionuclide Therapy (TRT) where theragnostic pairs are used to tailor a pers onalized treatment in terms of dose using PET initial imaging and subseque nt alpha or beta emitting radionuclides have introduced a clear and urgent need for more widespread and accurate PET imaging. Standard clinical scan ners are sub-optimal both in terms of cost that\, limit widespread use\, a s well as performance. Standard clinical PET scanners use sets of tightly arranged rings of detector modules\, consisting of scintillation crystals optically coupled to light sensors with readout electronics. They cover on ly a limited solid angle\, and just a small few percent fraction of the po sitron decays is registered. Novel long axial PET scanners with axial fiel d of view offer a very attractive solution to many of the challenges detai led above\, especially in terms of increased sensitivity and enabling fast dosimetry and biodistribution for pharmacokinetic studies\, that will pav e the way to personalized TRT. However\, these scanners pose significant challenges both financially and logistically. In this talk we present a jo int effort between JSI-Ljubljana\, FBK-Trento\, Univ-Barcelona\, Oncovisio n and MGH-Harvard-Boston to address these challenges using fast coincidenc e timing resolution. On the front electronics\, our challenge is to develo p a low-noise\, high-dynamic-range ASIC with a time resolution of 20 ps or better\, and with on-chip time-to-digital converter (TDC). To achieve sub -100 ps CTR we intend to explore 2.5 D integration with the photo-sensor. Recent advances in Time-of-flight (TOF) PET technology afford a rare oppor tunity to improve signal-to-noise-ratio (SNR) without increasing the cost associated with axial coverage by resorting to very sparse angular coverag e of the patient and long axial field coverage (>1m). This would yield aff ordable long axial PET scanners with increased sensitivity that can enable full body pharmacokinetics and pharmacodynamics.\n\nhttps://indico.koza.i f.uj.edu.pl/event/7/contributions/578/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/578/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Developing multi-photon total-body PET from plastic scintillators DTSTART;VALUE=DATE-TIME:20220713T074500Z DTEND;VALUE=DATE-TIME:20220713T080500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-683@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Szymon Niedźwiecki\; Jagiellonian University\, Pola nd ()\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/683/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/683/ END:VEVENT BEGIN:VEVENT SUMMARY:Estimation of 511 keV gamma scatter fraction in WLS layer in Total Body J-PET \; A simulation study DTSTART;VALUE=DATE-TIME:20220712T083700Z DTEND;VALUE=DATE-TIME:20220712T083900Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-744@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Keyvan Tayefi Ardebili\; Jagiellonian University\, P oland ()\nAuthor: Keyvan Tayefi Ardebili\nCo-authors: Szymon Niedżwiecki \, Paweł Moskal\nEstimation of 511 keV gamma scatter fraction in WLS laye r in Total Body J-PET\n\nKeyvan Tayefi Ardebili1\,2\, Szymon Niedżwiecki 1\,2\, Paweł Moskal 1\,2 on behalf of the J-PET collaboration.\n\n1Facult y of Physics\, Astronomy\, and Applied Computer Science\, Jagiellonian Uni versity\, Łojasiewicza 11\, 30-348 Kraków\, Poland\n2Center for Theranos tics\, Jagiellonian University\, Cracow\, Poland\n\nAbstract:\nA positron emission tomography (PET) scan plays an essential role in medical diagnost ics and monitoring therapy. A new generation of Total-Body PET scanners ba sed on plastic scintillators is being developed by the J-PET collaboration at Jagiellonian University [1].\nThe total body J-PET scanner comprises o f 7 rings\, each ring consisting of 24 modules. A single module is built o f 2 layers each one 16 axially arranged plastic scintillator strips of 33 cm in length\, read out by silicon photomultiplier (SiPM) arrays from both ends\, and an additional layer of 50 wavelength shifter (WLS) fibers. In this study\, an estimation of the scatter fraction of the Total-Body J-PET manufactured from plastic scintillator strips according to the NEMA NU 2- 2018 standards by using GATE software. The scatter phantom was simulated a s a solid cylinder with a length of 700 mm and an outside diameter equal t o 203 mm while at a radial distance of 45 mm we have a hole with a diamete r of 6.4 mm that linear source with total activity 1 MBq is placed [2\,3]. For data processing\, sinograms were generated and the Single Slice Rebin ning (SSRB) algorithm was used for the calculated scatter fraction amount. \nAcknowledgments:\nThe authors acknowledge support by the TEAM POIR.04.04 .00-00-4204/17 program\, the NCN grant no. 2021/42/A/ST2/00423 and the Sci Mat and qLife Priority Research Areas budget under the program Excellence Initative - Research University at the Jagiellonian University.\nReference s:\n1. P. Moskal\, et al. "Simulating NEMA characteristics of the modular total-body J-PET scanner - an economic total-body PET from plastic scintil lators"\, Phys. Med. Biol. 66 (2021) 175015.\n2. P. Kowalski\, et al. “E stimating the NEMA characteristics of the J-PET tomograph using the GATE p ackage”\, Phys. Med. Biol. 63 (2018) 165008\n3. P. Kowalski\, et al. “ Scatter fraction of the J-PET tomography”\, Acta Phys. Pol. B 47 (2016) 549\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/744/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/744/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: Promising detector concepts to advance coincidence time resolution for time-of-flight positron emission tomography DTSTART;VALUE=DATE-TIME:20220713T083500Z DTEND;VALUE=DATE-TIME:20220713T090000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-685@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Craig Levin\; Stanford University and University of Leeds\, USA ()\nWe are studying novel detection concepts to enhance coinci dence time resolution (CTR) for time-of-flight (TOF) positron emission tom ography (PET). In this short talk we will briefly discuss fundamental limi tations on PET CTR using scintillation detectors and describe new configur ations and electronic readout designs that attempt to address those constr aints. We also concisely describe an innovative\, non-scintillation-based\ , fast detection concept\, which borrows concepts from the field of optics \, that could in theory achieve ~1 ps CTR. If successful\, these technolog ies will lead to next generation systems that enhance TOF-PET's ability to visualize and quantify disease.\n\nhttps://indico.koza.if.uj.edu.pl/event /7/contributions/685/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/685/ END:VEVENT BEGIN:VEVENT SUMMARY:First clinical positronium imaging of patients DTSTART;VALUE=DATE-TIME:20220711T120000Z DTEND;VALUE=DATE-TIME:20220711T122000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-581@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Pawel Moskal\; Jagiellonian University\, Poland ()\n https://indico.koza.if.uj.edu.pl/event/7/contributions/581/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/581/ END:VEVENT BEGIN:VEVENT SUMMARY:Development of the normalization method for the Jagiellonian PET s canner DTSTART;VALUE=DATE-TIME:20220712T090500Z DTEND;VALUE=DATE-TIME:20220712T090700Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-781@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Aurélien Coussat\; Jagiellonian University\, Poland ()\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/781/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/781/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: A new Brain Dedicated PET scanner with 4D detector i nformation DTSTART;VALUE=DATE-TIME:20220713T090000Z DTEND;VALUE=DATE-TIME:20220713T092000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-686@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jose Maria Benlloch Baviera\, Institute for Instrume ntation in Molecular Imaging CSIC\, Spain ()\n"4D-PET is a new scanner ded icated to the brain examination. The scanner is based on an innovative det ector design\, that obtains full 3D impact position of the gamma ray insid e the detector crystal\, while providing also a precise (in the order of 2 50ps) determination of its impact time. The detector design is based on cr ystal slabs that allow also for good Depth of Interaction measurement\, cr itical for dedicated scanners. We will show in this presentation the resul ts obtained with real data at module level and the overall scanner expecte d performance with simulated data.”\n\nhttps://indico.koza.if.uj.edu.pl/ event/7/contributions/686/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/686/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Development of a spatial sensitive detector for posi tronium inertial sensing measurements DTSTART;VALUE=DATE-TIME:20220714T065500Z DTEND;VALUE=DATE-TIME:20220714T071500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-695@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Sebastiano Mariazzi\; University of Trento\, Italy ( )\nAuthor:\nSebastiano Mariazzi\nCo-authors:\nRuggero Caravita\, Lisa Glö ggler\, Luca Povolo\, Luca Penasa\, Sushil Sharma\, Pawel Moskal\, Roberto Sennen Brusa\nRecent experiments have demonstrated the possibility to pro duce positronium in the long-lived 23S state (lifetime of 1142 ns) via 13S →33P [1] laser excitation followed by spontaneous [2\, 3] or stimulated [4] 33P→23S transition. This excitation scheme has shown to be suitable for the production of a monochromatic source of 23S positronium [3\,5].\nT he employment of such a source of 23S positronium has been proposed to per form the first force-sensitive inertial studies\, including gravity\, with a purely leptonic system [6]. In order to perform these studies\, three m ain steps are necessary: i) a monochromatic beam of 23S positronium has to be produced\, ii) the 23S beam has to cross a deflectometer/interferomete r device with consequent formation of the fringe pattern and iii) the disp lacement of the fringe pattern determined by an external force exerted on positronium has to be detected.\nIn this work\, the aforementioned steps a re presented. Particular attention will be dedicated to the description of the possible detection schemes that could be used for resolving the fring e pattern displacement. Recent results in the development of a spatial sen sitive detector for positronium are shown and the perspectives are discuss ed.\n\n[1] S. Aghion et al. (AEgIS Collaboration) Phys. Rev. A 94\, 012507 (2016)\n[2] S. Aghion et al. (AEgIS Collaboration) Phys. Rev. A 98\, 0134 02 (2018)\n[3] C. Amsler et al. (AEgIS Collaboration) Phys. Rev. A 99\, 03 3405 (2019)\n[4] M. Antonello et al. (AEgIS Collaboration) Phys. Rev. A 10 0\, 063414 (2019)\n[5] S. Mariazzi et al. (AEgIS Collaboration) Acta Phys. Pol. A 137\, 91 (2020)\n[6] S. Mariazzi et al. (AEgIS Collaboration) Euro p. Phys. J. D 74\, 79 (2020)\n\nhttps://indico.koza.if.uj.edu.pl/event/7/c ontributions/695/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/695/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Positron Annihilation Spectroscopy of oxygen content tissue-equivalent samples DTSTART;VALUE=DATE-TIME:20220711T124000Z DTEND;VALUE=DATE-TIME:20220711T130000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-582@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Ali Biganeh\; Nuclear Science and Technology Researc h Institute\, Iran ()\nPositron Annihilation Spectroscopy (PAS) has numero us applications in material science such as studies of structural defects\ , free volumes\, porous materials\, and their chemical environments. In re cent years\, the applications of this technique in chemical processes\, ra diobiology\, and medicine have been the subject of research by many resear chers [1\, 2]. PAS includes Coincidence Doppler Broadening Spectroscopy (C DBS) of annihilation radiation to determine the momentum of the electrons involved in the annihilation process and Positron Annihilation Lifetime Sp ectroscopy (PALS) for the investigation of the mechanism behind the positr onium annihilation in the sample. In this paper\, the possible application of the PALS technique for the characterization of healthy and cancer tiss ues is evaluated. The purpose of the experimental part of this work is to investigate the sensitivity of the PALS technique to the oxygen concentrat ion in tissue-equivalent samples.\nThe accepted hypothesis for this resear ch is that the concentration of oxygen in cancer tissues is less than in h ealthy tissues due to the massive cell proliferation [3]. To conduct the e xperiments\, the PALS spectrometer based on digital signal processing has been designed\, commissioned\, and optimized in the NSTRI positron lab. Th is spectrometer makes it possible to record the time difference of events with a channel width of 10 ps and the timing resolution of 173 ps using th e plastic scintillation detectors. To determine the sensitivity of the tec hnique to the presence of the polar groups including carbon-oxygen boundin g\, 4 polymer samples were measured using PALS and CDBS techniques\, and t he correlation between the parameters was clarified. The results of this i nvestigation confirmed that the position and height of the peak in the Orb ital Electron Momentum Spectrum (OEMS) obtained in the Doppler experiment and the component of the positronium lifetime in the PALS technique are bo th sensitive to the presence of oxygen in the content [4]. To determine th e PALS parameters related to the amount of oxygen\, 6 tissue-equivalent po lymers with different concentrations of oxygen were selected. The positron lifetime spectra in these samples were measured using the developed digit al PALS spectrometer and the results were analyzed using LT-10 software. T he results of this experiment confirmed that in general\, as the oxygen co ncentration in the sample increases\, due to the quenching role of oxygen atoms in the formation of the positronium atoms\, the I_3 and τ_3 paramet ers decrease significantly. However\, in the samples with a difference of about 4% in the oxygen concentration\, the behavior analysis of the positr onium lifetime and its intensity requires a systematic study of the effect of density\, porosity\, crystallinity\, and the bond type in the polymer samples. The results of this work apply to the development of a tumor imag ing system based on the PALS technique.\nReferences\n[1] Moskal\, Paweł\, and Ewa Stępień. "Positronium as a biomarker of hypoxia." Bio-Algorithm s and Med-Systems (2021).‏\n[2] Stepanov\, P. S.\, et al. "Interaction o f positronium with dissolved oxygen in liquids." Physical Chemistry Chemic al Physics 22.9 (2020): 5123-5131.‏\n[3] Brahimi-Horn\, M. Christiane\, Johanna Chiche\, and Jacques Pouysségur. "Hypoxia and cancer." Journal of molecular medicine 85.12 (2007): 1301-1307.‏\n[4] Zare\, Mahshid\, et a l. "Experimental investigation of the oxygen sensing ability of positron a nnihilation spectroscopy for tumor imaging." Radiation Physics and Enginee ring (2022).‏\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/ 582/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/582/ END:VEVENT BEGIN:VEVENT SUMMARY:Development of Polarization-Sensitive Positron Emission Tomography Demonstrator based on Single-layer gamma-ray polarimeters DTSTART;VALUE=DATE-TIME:20220713T092000Z DTEND;VALUE=DATE-TIME:20220713T094000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-687@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Siddharth Parashari\; University of Zagreb\, Croatia ()\nThe utilization of polarization correlations of gamma-rays originatin g from para-positronium annihilation is emerging as an important additiona l handle to identify true coincidences in Positron Emission Tomography (PE T) showing the potential to improve the signal to noise ratio in this imag ing modality [1-3]. It was demonstrated experimentally that the polarizati on correlations of annihilation quanta could be successfully measured usin g segmented single-layer scintillator matrices [4]. In that proof-of-conce pt study we used 4x4 Lutetium Fine Silicate (LFS) scintillator matrices re ad out by silicon photomultipliers (SiPMs) to reconstruct the Compton scat tering of the gammas in a single segmented scintillator layer acting both as the scatterer and as the absorber. In events where both quanta undergo Compton scattering\, the difference between their azimuthal scattering ang les could be used to deduce the initial relative polarizations\, since the two are highly correlated. In a subsequent exploratory study we tested fi ve detector configurations of 64 pixels each of either GaGG:Ce or LYSO:Ce crystals with cross section varying from 1.9×1.9 mm2 to 3.0×3.0 mm2 with the effective pitch of 2.2 mm and 3.2 mm\, respectively\, aiming to achie ve optimal sensitivity to measure polarization correlations of annihilatio n quanta [5]. At the same time\, Geant4 simulations of the investigated co nfigurations were performed in support of the experimental evidence [6]. P olarimetric performance of different module configurations were assessed b y reconstructing the Compton azimuthal angle difference of the annihilatio n gamma pair in measurements with a 22Na point source (≈1 kBq) positione d between modules. The results showed that higher polarimetric modulation factors are achieved by modules with finer segmentation\, the highest bein g\, μ=0.34±0.1\, for the GaGG crystals of 1.9×1.9×20 mm3 size with 2.2 mm pitch.\nThe current research focuses on the development and testing of a PET demonstrator (scanner) based on the single-layer polarimeters. The advantage of the single-layer Compton detectors\, as opposed to multi-laye r configurations\, is that their scaling up to large systems does not add complexity or cost\, compared to standard PET devices. The demonstrator co mprises four large modules with matrices of 16×16 scintillator pixels rea d out by SiPMs\, a pair with 3.2 mm pitch and another with 2.2 mm segmenta tion pitch. They are placed on radially sliding detector arms enabling cho ice of the ring diameter from 420 to 700 mm. The mechanical construction a lso enables precise rotation around the scanner axis to cover the full ang ular range. The SiPM control and the data acquisition are done by the TOFP ET2 system [7]. We will report on the overall performance of the detector modules and the key parameters driving the sensitivity to detect polarized gamma-rays. We will also report on the development of the demonstrator an d discuss its potential use with point as well as extended sources keeping gamma-ray polarization as key interest.\n\nReferences:\n1. A. McNamara\, et al.\, Phys. Med. Biol.\, vol. 59\, Nov. 2014\, pp. 7587–7600 .\n2. M. Toghyani\, et al.\, Phys. Med. Biol.\, vol. 61\, Aug. 2016\, pp. 5803–5 817.\n3. D.P. Watts\, et al.\, Nat. Commun. 12\, 2021\, 2646.\n4. M. Makek \, et al.\, Nucl. Instrum. Methods Phys. Res. A\, vol. 958\, Apr. 2020\, A rt. no. 162835.\n5. S. Parashari\, et al.\, arXiv:2205.01075.\n6. A.M. Ko žuljević et. al.\, Condensed Matter 2021\, 6\, 43.\n7. A.D. Francesco et al.\, J. Instr.\, 2016\, 11\, Art. no. C03042.\n\nhttps://indico.koza.if. uj.edu.pl/event/7/contributions/687/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/687/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: Designed Protein Cages: Current State and Potential Medi cal Applications DTSTART;VALUE=DATE-TIME:20220715T090000Z DTEND;VALUE=DATE-TIME:20220715T092500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-758@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jonathan Heddle\; Malopolska Centre of Biotechnology \, Poland ()\nDesigned proteins offer us the potential of matching or exce eding the capabilities of nature’s own naturally-occurring protein nanom achines which demonstrate a wonderous array of properties. Protein cages a re hollow\, typically spherical nanoscale protein assemblies which in natu re have multiple uses such as materials storage\, genome delivery (viruses ) and catalysis (enzymes). As such it is attractive to design and produce artificial cages with properties such as multiple antigen display on the e xterior for use as vaccines\, and the ability to protect and carry therape utically useful macromolecules in the interior for use as drug delivery sy stems. Making such systems programmable is a desirable feature and require s finding a way of opening such cages on demand to release cargo when and where required. In this presentation I will give an overview of the field and our own progress in producing a programmable artificial protein cage.1 \,2\,3\,4\,5\,6\n\nReferences\n1. Malay\, A. D. et al. An ultra-stable gol d-coordinated protein cage displaying reversible assembly. Nature 569\, 43 8–442 (2019).\n2. Malay\, A. D. et al. Gold Nanoparticle-Induced Formati on of Artificial Protein Capsids. Nano Lett. 12\, 2056–2059 (2012).\n3. Imamura\, M. et al. Probing structural dynamics of an artificial protein c age using high-speed atomic force microscopy. Nano Lett. 15\, 1331–1335 (2015).\n4. Naskalska\, A. et al. An artificial protein cage delivers acti ve protein cargoes to cell interior. Biomacromolecules 22\, 4146–4154 (2 021).\n5. Stupka\, I. et al. Chemically induced protein cage assembly with programmable opening and cargo release. 9424\, (2022).\n6. Majsterkiewicz \, K. et al. Artificial Protein Cage with Unusual Geometry and Regularly E mbedded Gold Nanoparticles. Nano Lett. 22\, 3187–3195 (2022).\n\nhttps:/ /indico.koza.if.uj.edu.pl/event/7/contributions/758/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/758/ END:VEVENT BEGIN:VEVENT SUMMARY:Reconstruction of photon’s interaction position within plastic s cintillator based on the WLS strips readout for the Total-Body J-PET DTSTART;VALUE=DATE-TIME:20220713T094000Z DTEND;VALUE=DATE-TIME:20220713T100000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-688@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Szymon Parzych\; Jagiellonian University\, Poland () \nRegistration of gamma quanta is a fundament for many experiments from th e field of physics\, as well as in nuclear medicine. One of the approaches for its enabling is provided by the means of plastic scintillator detecto rs. Developed by the J-PET Collaboration multi-purpose device - J-PET tomo graph [1\,2]\, consists of axially arranged plastic scintillator strips\, read out at both ends by a pair of silicon photomultipliers [3]. Independe nt on application of this system\, either as a PET tomograph or proton bea m range detector during proton therapy\, the axial coordinate of the photo n interaction within the scintillator is derived from the time difference of scintillation signals arrival on the opposite sides of the scintillator . Therefore\, the axial spatial resolution for the interaction point recon struction is limited by the timing resolution. A way to improve the axial resolution was presented in [4]\, where it has been examined that utilizat ion of multiple orthogonally oriented wavelength shifter (WLS) strips can enhance the axial coordinate determination. Nonetheless\, due to the lack of the depth-of-interaction detection\, the rest of interaction position c oordinates is set to the respective scintillators center.\nIn this work\, a semi-depth-of-interaction method for radial coordinate reconstruction wi ll be introduced based on the simulations of the aforementioned setup. If interaction occurred near to the WLS strips\, the photons emitted within t he cone dictated by the total internal reflection angle will largely inter act in the nearest region\, while in case of further place of interaction this region correspondingly expands. Moreover\, a different approaches to the axial coordinate reconstruction will be presented.\n\nAcknowledgements \nThe abovementioned work is presented on behalf of the J-PET Collaboratio n. This work was supported by the TEAM POIR.04.04.00-00-4204/17 program\, the NCN grant no. 2021/42/A/ST2/00423 and the SciMat and qLife Priority Re search Areas budget under the program Excellence Initiative - Research Uni versity at the Jagiellonian University. The study was funded by “Laborat ories of the Youth” as part of the “Excellence Initiative - Research U niversity” program at the Jagiellonian University in Kraków.\n\nhttps:/ /indico.koza.if.uj.edu.pl/event/7/contributions/688/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/688/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: High throughput cost-efficient Flat panel monolithic Walk Through PET DTSTART;VALUE=DATE-TIME:20220713T072500Z DTEND;VALUE=DATE-TIME:20220713T074500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-682@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Stefaan Vandenberghe\; Ghent University\, Belgium () \nThe first Total Body PET scanner have been installed in several (>10) in stitutions in Europe despite its high acquisition price of 8-10 MEuro. The first experiences of these groups have been closely followed and importan t conclusions are:\n•Scan times of 15 sec to 1 min deliver excellent qua lity for standard doses (used on nowadays standard short axial FOV)\n•Da ta handling and size are challenges due to the very high sensitivity\n•P atient throughput is potentially high (one patient every 3 min) not limite d anymore by the scan time but mostly by patient handling and a shortage o f personnel\n\nAlso in the clinical world there are gradual changes ongoin g and expected. PET is not only used for detection but more and more for ( expensive) therapy prediction and follow-up. There will be more and more s elected screening based on genetic information\, blood test and/or patient history. Even with selected screening there will be a high number of pati ents and repeat scans. Patients will also quite often healthy (or in an ea rly stage of cancer).\n\nThis change in the patient population and clinica l needs can be dealt with PET scanners with the following properties\n•L ower dose imaging (healthy patients)\n•Faster imaging + higher throughpu t\n•Lower cost imaging (systems + procedure)\n•Less personnel per scan (shortage of personnel)\n\nTherefore we redesigned TB-PET towards a fast technique with high throughput. Using the latest monolithic detector techn ology we propose a new design\, departing from the classical patient posit ioning on a bed. We propose an upright scanner (similar to airports mm-wav e scanners or planar X-ray) using TOF technology. This optimises detector area and avoids time consuming patient positioning.\n\nThe following key e lements enable such a design:\n•The presence of TOF gives us direct tomo graphic information and obviates the need for complete coverage of the pat ient.\n•Scatter and attenuation correction can be done with Deep learnin g\n•CT can be avoided and leads to lower dose to the patient\n•The siz e of the detectors is based on measurement from a PET patient population\n \nThe main benefits of this design regarding cost and performance are:\n •We need 1.9 x less detector surface for the same axial FOV (due to clos e detectors)\n•The effective sensitivity is higher as there are more obl ique incidences with flat panels\n•Monolithic detector technology (High resolution + Depth of interaction) enables system resolution below 2mm (ov er the whole FOV).\n\nFinally the potential clinical throughput\, patient experiencse and patient motion was evaluated using a first mockup flat pan el scanner in a NM department.\n\nhttps://indico.koza.if.uj.edu.pl/event/7 /contributions/682/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/682/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Kaonic atoms at DANE: where we are and where we go? DTSTART;VALUE=DATE-TIME:20220712T130000Z DTEND;VALUE=DATE-TIME:20220712T132000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-673@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Catalina Curceanu on behalf of Dr Alessandro Scordo\ ; National Laboratory of Frascati (LNF)\, Italy ()\nThe DAΦNE machine at the INFN Laboratories of Frascati is still the most suitable facility in t he world\, in terms of purity of the kaon beam\, luminosity\, and kinemati c conditions\, to perform measurements of kaonic atoms.\nRecent progress i n the field of X-ray detectors and their readout electronics contributed\, in these last years\, to a renewed interest in new and more precise measu rements.\nBeyond the SIDDHARTA-2 experiment\, presently installed on the D AΦNE Interaction Point exploiting 450 mm thick Silicon Drift Detectors (S DD) to measure for the first time X-rays from kaonic transitions in deuter ium\, several other important measurements are still planned or proposed.\ nThese new measurements\, among which transitions in kaonic helium\, carbo n\, sulfur\, lead\, wolfram\, nitrogen\, and molybdenum\, are now feasible thanks to new technologies: 1 mm thick SDDs\, CdZnTe\, and HPGe detectors as well as crystal spectrometers and TES microcalorimeters.\nIn this talk \, an overview of the already planned and foreseen measurements\, together with others proposed for future campaigns\, will be presented together wi th their physics case\, possible impacts\, and details of the experimental setups.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/673/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/673/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: Artificial intelligence in cardiovascular Imaging DTSTART;VALUE=DATE-TIME:20220713T120500Z DTEND;VALUE=DATE-TIME:20220713T123000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-689@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Piotr Slomka\; Cedars-Sinai Medical Center\, USA ()\ nCardiovascular imaging has been experiencing rapid development recently t hanks to refinements in imaging technologies and software for image analys is. Recent breakthroughs in data science\, machine learning\, and artifici al intelligence (AI) have been applied broadly to pre- and post-processing of imaging data.\nNovel computing approaches hold the promise of improved image quality\, automated detection and segmentation of abnormal regions\ , image registration\, and modality-to-modality transformation. There is a wealth of imaging information that offers new opportunities – while thi s can be automatically extracted from medical images\, new methods are req uired for integrating the diverse data such as multimodal images and elect ronic health records.\nAI may allow meaningful improvements in diagnostic accuracy and quantitative outcome prediction. Interpretable AI systems can explain the primary factors driving the diagnosis or prognosis to both th e physician and patient\, dispelling the “black-box” perception of AI. I will overview the latest AI developments in cardiovascular imaging\, bo th classical machine learning and deep learning focusing on nuclear medici ne and CT\, including application in PET imaging. I will also discuss issu es related to the validation and deployment of AI systems for medical imag ing applications.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contribution s/689/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/689/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: From High Performance Computing to PET medical imagi ng - EuroHPC PL software platform for novel techniques and artificial intelligence methods in the context of the total-body J-PET developm ent DTSTART;VALUE=DATE-TIME:20220713T123000Z DTEND;VALUE=DATE-TIME:20220713T125000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-690@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Wojciech Krzemień\; National Centre for Nuclear Res earch\, Poland ()\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/ 690/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/690/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: PET imaging innovations DTSTART;VALUE=DATE-TIME:20220713T132000Z DTEND;VALUE=DATE-TIME:20220713T134500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-691@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Taiga Yamaya\; National Institutes for Quantum and R adiological Science and Technology (QST)\, Japan ()\nIn current PET\, only a few percent of gamma rays emitted from a patient are used for imaging. Therefore\, improvement of the sensitivity is a hot topic worldwide. Axial extension\, which is referred as total-body PET\, is essential in terms o f the sensitivity improvement. In organ dedicated imaging\, on the other h and\, it is possible to improve the sensitivity without increasing the num ber of detectors. Improvement of spatial resolution is also expected by el iminating the photon non-collinearity effect.\nIn the former part of this presentation\, development of brain-dedicated PET systems will be reviewed . Among them\, we have recently developed VRAIN\, a PET system with a hemi spherical detector arrangement [1]. The hemispherical geometry fits the he ad best\, and minimizes the photon non-collinearity effect by reducing the detector-to-detector distance.\nIn the latter part of the presentation\, alternative approaches to improve the sensitivity rather than increasing t he solid angle of the measurement system will be reviewed. Among them\, wh ole gamma imaging (WGI) is a novel concept of combined PET with Compton im aging. An additional detector ring\, which is used as the scatterer\, is i nserted in a conventional PET ring so that single gamma rays can be detect ed by the Compton imaging method. In addition to conventional PET and Comp ton imaging\, further large impact can be expected for triple gamma emitte rs such as Sc-44 (~4 h half-life)\, that emits a positron and a 1157 keV g amma ray almost at the same time. In principle\, only a few decays would b e enough to localize the source position by calculating intersection point s of a 511 keV line-of-response with a 1157 keV Compton cone. We developed a prototype of the WGI system [2][3]\, and a Na-22 point source\, which e mits a 1275 keV gamma ray soon after a positron decay\, was measured as an alternative to Sc-44. In the triple gamma imaging\, where only simple bac kprojection was applied and no image reconstruction algorithm was applied\ , spatial resolution for the Na-22 point source was 4.8 mm FWHM (8 cm off- center) - 5.7 mm FWHM (center). WGI can be also used to measure positroniu m lifetime [4]\, which may enable a new field of “quantum PET (Q-PET)” . One possible application of Q-PET is hypoxia imaging of tumor patients [ 5].\n\n[1] E. Yoshida\, Hideaki Tashima\, Go Akamatsu\, et al.\, “245 ps -TOF brain-dedicated PET prototype with a hemispherical detector arrangeme nt\,” Phys. Med. Biol.\, 65\, 145008\, 2020.\n[2] E. Yoshida\, H. Tashim a\, K. Nagatsu\, et al.\, "Whole gamma imaging: a new concept of PET combi ned with Compton imaging\," Phys. Med. Biol.\, 65\, 125013\, 2020.\n[3] H. Tashima\, E. Yoshida\, H. Wakizaka\, et al.\, "3D Compton image reconstru ction method for whole gamma imaging\," Phys. Med. Biol.\, 65\, 225038\, 2 020.\n[4] P. Moskal\, B. Jasińska\, E.Ł. Stępień\, et al.\, “Positro nium in medicine and biology\,” Nat. Rev. Phys. 1\, 527-529\, 2019.\n[5] K. Shibuya\, H. Saito\, F. Nishikido\, et al.\, "Oxygen sensing ability o f positronium atom for tumor hypoxia imaging\," Commun. Phys. 3\, 173\, 20 20.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/691/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/691/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Multi-isotope imaging and quantum chemical sensing w ith PET and SPECT nuclides DTSTART;VALUE=DATE-TIME:20220713T134500Z DTEND;VALUE=DATE-TIME:20220713T140500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-692@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kenji Shimazoe\; The University of Tokyo\, Japan ()\ nMulti-isotope imaging is important for investigating multi-molecule dynam ics in individuals. PET and SPECT dual tracer imaging in vivo is demonstra ted with a developed Compton PET hybrid camera. In nuclear medicine imagin g\, quantum chemical sensing\, such as pH and chemical state of molecule\, can be additional value to accumulation imaging. pH sensing and imaging i s demonstrated with liquid state In-111 SPECT nuclide by double-photon ima ging method. Recent works on multi-isotope imaging and quantum sensing wit h double photon imaging will be introduced.\n\nhttps://indico.koza.if.uj.e du.pl/event/7/contributions/692/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/692/ END:VEVENT BEGIN:VEVENT SUMMARY:Polarization and directional correlations of γ-rays for nuclei: S cope in PET DTSTART;VALUE=DATE-TIME:20220713T142500Z DTEND;VALUE=DATE-TIME:20220713T144500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-693@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Pragya Das\; Indian Institute of Technology Bombay\, India ()\nThe spectroscopic investigation of nuclei at high spin states h as led to many discoveries\, e.g.\, exotic shapes\, super-deformation\, sh ape coexistence\, and chiral symmetry. In this endeavor\, the accurate spi n-parity assignment to nuclear states is crucial. Many studies in the lite rature have focused on finding the directional correlation ratios (DCO) fo r the assigning spins without any polarization measurement for parity dete rmination. The use of polarization-directional correlation (PDCO) [1] not only determines the parity\, but can also easily distinguish stretched and non-stretched γ-transitions\, allowing to establish both spin and parity . We have confirmed some earlier tentative spin-parities in 128I and 129Xe and modified a few of them with our new results on mixing ratios using PD CO. It is needless to mention here that a fresh understanding of the nucle ar structure is required if the spin-parity of the bandhead state is chang ed.\nWe performed an experiment via the fusion-evaporation reaction – 11 B (124Sn\; α3n\, p5n) 128I\, 129Xe – using the Pelletron accelerator at the Tata Institute of Fundamental Research (Mumbai\, India). The experime ntal set-up (INGA) consisted of 21 Compton suppressed HPGe clover detector s. The list-mode data [2] were utilized to construct the asymmetric matrix for finding PDCO. We used 90∘ detectors as polarimeters (θpil) and all other detectors as directional detectors (θdir)\, and followed the PDCO formalism by Droste et al. [1].\nFor the case of 129Xe\, we assigned [3] t he bandhead spin-parity 21/2+ to a 2180 keV state decaying via 604 keV γ- ray\, based on only the DCO information. Our finding (21/2+) and other ava ilable results for the same state – 19/2+ by Huang et al. [4] and 19/2 – by Helppi et al. [5] – were all in complete disagreement. So\, it be came imperative to confirm our assignment by further analyzing the PDCO da ta\, which enabled us to establish the same state 21/2+. Moreover\, there were other discrepancies\, and we could resolve them by critically examini ng the PDCO contour plots\, i.e.\, polarization (P) vs. DCO ratios (RDCO) for different values of mixing ratios. It was possible to distinguish stre tched and non-stretched transitions. Notably\, no polarization measurement existed in the literature prior to our work.\nIn the context of using pol arization correlation of coincident γ-rays\, the property of entanglement (orthogonal polarization) of annihilation photons (511 keV) has immense p otential in positron emission tomography (PET). It can help classify the t rue coincidence events amongst the scattered\, random\, and multiple event s. However\, the research area has not been fully explored\, probably beca use of experimental difficulties. Only a few simulation-based studies exis t [6\, 7]. We have also tried a preliminary study [8] with many simplified assumptions but have not yet succeeded in improving the image quality.\n\ n[1] Ch. Droste et al.\, Nucl. Instr. Meth. Nucl. Res. A 378 (1996) 518.\n [2] U. Lamani et al.\, Nucl. Phys. A 1014 (2021) 122220.\n[3] V. K. Pasi e t al.\, JPS Conf. Proc. 6 (2015) 030016.\n[4] Y. Huang et al.\, Phys. Rev. C 93\, (2016) 064315.\n[5] H. Helppi et al.\, Nucl. Phys. A 357 (1981) 33 3.\n[6] A. L. McNamara et al.\, Phys. Med. Biol. 59 (2014) 7587.\n[7] M To ghyani et al.\, Phys. Med. Biol. 61 (2016) 5803.\n[8] Satyajit Ghosh\, Ph. D. thesis submitted (2022)\, IIT Bombay\, India.\n\nhttps://indico.koza.i f.uj.edu.pl/event/7/contributions/693/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/693/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: Interaction of positron and positronium with gases in li quids and development of a new positron beam for advancing such fundamenta l studies DTSTART;VALUE=DATE-TIME:20220714T063000Z DTEND;VALUE=DATE-TIME:20220714T065500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-694@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Farida Selim\; Bowling Green State University\, USA ()\nThrough the last decades positron and positronium annihilation have be en powerful tools for fundamental studies in physics\, chemistry\, and mat ter. Now the recent development of novel type of positron emission tomogra phy (PET) at the Jagiellonian University in Krakow stimulates great intere st to understand positron/positronium interactions with gases dissolved in liquids and urges new research avenues in positron/positronium science. I n this talk I will give an example of such research and describe the devel opment of a new beam to advance such fundamental studies of positron and p ositronium in a wide range of science. I will discuss how it can be used t o advance our understanding of positron and positronium physics related to medicine. Lastly\, future perspectives of positron and positronium applic ations in medical diagnostics and therapeutic will be given.\n\nhttps://in dico.koza.if.uj.edu.pl/event/7/contributions/694/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/694/ END:VEVENT BEGIN:VEVENT SUMMARY:Precision tests of discrete symmetries in decays of positronium wi th the J-PET detector DTSTART;VALUE=DATE-TIME:20220714T073500Z DTEND;VALUE=DATE-TIME:20220714T075500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-697@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Eryk Czerwiński\; Jagiellonian Unversity\, Poland ( )\nThe Jagiellonian PET (J-PET) detector is the only device which enables estimation of positronium spin axis together with determination of polariz ation of photons from positronium annihilation on the event-by-event basis . This allows to test angular correlations in the annihilations of the lig htest leptonic bound system and explore a new class of discrete symmetry o dd operators that were not investigated before. Such measurement is equiva lent to a search for possible violation of combined charge\, parity\, and time-reversal symmetries as yet another approach for a test of New Physics . Positronium\, a bound state of electron and positron\, as the lightest m atter-antimatter system and at the same time an eigenstate of the C and P operators is an unique probe in such endeavor. With first measurements dem onstrating such capabilities we are able to reach the precision of CPT and CP tests at permill level. In the talk we will describe experimental tech niques and recent results of discrete symmetries tests in the decays of po sitronium in a whole available phase-space.\n\nhttps://indico.koza.if.uj.e du.pl/event/7/contributions/697/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/697/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Research in Neutron Capture Therapy at University of Pavia DTSTART;VALUE=DATE-TIME:20220714T084000Z DTEND;VALUE=DATE-TIME:20220714T090000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-698@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Saverio Altieri\; University of Pavia\, Italy ()\nBo ron Neutron Capture Therapy (BNCT) is an experimental radiotherapy treatme nt characterised by selectivity at the cellular level based on the 10B(n\, alpha)7Li reaction induced by thermal neutrons\; the reaction products\, a lpha and 7Li have a biological efficacy comparable to that of C-ions used in Hadrontherapy\; and they have the added advantage of being produced dir ectly in the tumour cells\, where they release their destructive energy\, without having to pass through the layers of healthy tissue overlying the tumour.\n\nToday\, the international BNCT community\, after its experience with neutron from research nuclear reactors\, finally has sources produce d with proton accelerators via p\,Be or p\,Li reactions. Accelerators have the advantage of being easy to install in a clinical facility and therefo re offer the possibility to treat patients in a more appropriate environme nt.\n\nThe University of Pavia has a long tradition in the field of BNCT b ased on the use of the Triga Mark II nuclear research reactor of the LENA laboratory\; here in the past BNCT was applied to treat diffuse liver meta stases\, using the auto-transplantation technique with the irradiation of the explanted liver in the reactor's Thermal Column.\n\nToday\, preclinica l research\, in collaboration with INFN\, many Italian Universities and in ternational Institutions and Laboratories\, is still very active on variou s aspects of BNCT: research into new boron carriers with in vitro and in v ivo toxicity and efficacy tests\, measurement of boron concentration in bi ological samples by alpha spectrometry\, neutron autoradiography\, online measurement of boron dose by SPECT and/or Compton Camera technique with Cd ZnTe (CZT) detectors.\n\nUNIPV has an intense collaboration with the Centr e for Oncology Hadrontherapy (CNAO) where a BNCT facility based on the TAE -TLS p-Li accelerator will be ready in a couple of years. Two treatment ro oms are planned\, one dedicated to patients and one to BNCT research.\n\nI n the talk\, after a brief introduction to the BNCT technique\, the above- mentioned topics will be presented.\n\nhttps://indico.koza.if.uj.edu.pl/ev ent/7/contributions/698/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/698/ END:VEVENT BEGIN:VEVENT SUMMARY:Towards including radiation quality in proton therapy treatment pl anning and dosimetry DTSTART;VALUE=DATE-TIME:20220714T090000Z DTEND;VALUE=DATE-TIME:20220714T092000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-699@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jan Gajewski\; Institute of Nuclear Physics Polish A cademy of Sciences\, Poland ()\nProton radiotherapy is recognised as an ef fective treatment method of tumours\, which allows for increased sparing o f normal tissues compared to conventional radiotherapy. Further improvemen t of clinical proton radiotherapy can be obtained with development of adva nced treatment planning and dosimetry methods. The uncertainties in the bi ological modelling of the radiation effectiveness pose the major limitatio n of this treatment modality\, which increases the risk of complications c aused by proton irradiations\, such as the development of secondary tumour s or necrosis. Therefore\, one of the main challenges in proton radiothera py is to improve the current strategies of treatment planning by accountin g for radiation quality described by means of the particle stopping power (Linear Energy Transfer - LET). Nowadays\, LET is not considered in the cl inical routine of treatment planning and dosimetry even if its engagement would fully allow to exploit the clinical advantages of proton radiotherap y.\n\nWithin the seminar\, an overview of the computational and experiment al methods for proton therapy treatment planning and dosimetry\, clinicall y used at CCB and in other proton facilities will be presented. Moreover\, it will be shown how to introduce radiation quality information in proton treatment. This part includes the development of (i) dosimetrical methods based on TimePix semiconductor pixel detectors developed in the framework of the CERN Medipix collaboration and (ii) computational methods based on fast GPU-accelerated Monte Carlo codes. The inclusion of radiation qualit y in the treatment planning and dosimetry has the potential to improve the precision of patient treatment in proton therapy.\n\nhttps://indico.koza. if.uj.edu.pl/event/7/contributions/699/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/699/ END:VEVENT BEGIN:VEVENT SUMMARY:Safe proton radiotherapy for patients with metallic spine stabiliz ation system DTSTART;VALUE=DATE-TIME:20220714T092000Z DTEND;VALUE=DATE-TIME:20220714T094000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-700@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kamil Kieislewicz\;Centre of Oncology\, Maria Sklodo wska-Curie Memorial Institute Krakow Branch\, Poland ()\nIntroduction\nSin ce the beginning of proton radiotherapy in Krakow\, skull base tumors are the main sites treated here. Due to the need to deliver a high dose of ion izing radiation (70-74Gy RBE) and the close presence of critical structure s\, such brainstem\, optic chiasm\, optic nerves\, the use of a proton bea m creates better opportunities for dose escalation to the target volume co mpared to photon radiotherapy. The problem when planning such treatment is the presence of metal stabilizers in about 40% of patients\, which increa se the uncertainty of the planned dose deposition.\n\nMaterial and methods \nAcquisitions of CT layers necessary for treatment planning were performe d on the Siemens Somatom Definition AS apparatus using the iMAR\, an optim ized iterative algorithm for reducing metal artifacts. Then\, a dedicated calibration curve for the Varian Eclipse treatment planning system (HU vs. RSP) was prepared. For each patient with a stabilizer\, computed tomograp hy was additionally reconstructed in the extended HU scale to transfer the necessary information about the implant density for treatment planning al gorithm. Treatment plans were also based on individually defined structure s - so-called target per field (volume to be irradiated from a given thera peutic field - beam) in order to avoid fragmented areas of artifacts recon structed in an unacceptable way. The geometry of the beams was also optimi zed in relation to the metal element and critical organs.\n\nResults and c onclusions\nThe presented procedure allowed for the safe proton radiothera py treatment using scanning beam in over 50 patients with metallic stabili zers\, which was additionally confirmed by Monte Carlo simulations with th e FRED tool (Fast paRticle thErapy Dose evaluator).\n\nhttps://indico.koza .if.uj.edu.pl/event/7/contributions/700/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/700/ END:VEVENT BEGIN:VEVENT SUMMARY:The development of the QETIR image reconstruction software for the Total-Body J-PET application DTSTART;VALUE=DATE-TIME:20220714T151000Z DTEND;VALUE=DATE-TIME:20220714T152500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-767@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Meysam Dadgar\; Jagiellonian University\, Poland () \nAuthors:\nMeysam Dadgar\, Faranak Tayefi Ardebili\n\nThe unique features that PET scanners have provided to the specialists in diagnosing diseases and investigating the physiology of the body have facilitated the develop ment of a more advanced generation of tomographs in order to improve their performance\, called Total-Body PET scans.\nDue to the larger AFOV\, TB P ET scanners provide more extensive detection coverage around the patient's body. They have significantly increased the probability of detecting phot ons emitted from the patient's body. This issue has increased the sensitiv ity of TB PETs and enhanced their accuracy in detecting and locating tumor s with smaller dimensions. This unique feature can increase the chances of saving the patient by detecting tumors in the early stages.\nAlong with t he numerous advantages of developing TB PETs\, the construction cost and m aintenance of these systems\, due to a large number of electronic componen ts and detectors\, have become one of the biggest obstacles to their wides pread use in diagnostic and research centers.\nJ-PET collaboration at Jagi ellonian University\, as one of the leading research groups in developing cost-effective larger AFOV PET based on plastic scintillators\, has been a ble to introduce a new generation of the systems mentioned above by overco ming the existing limitations.\nBesides the hardware challenges in the con struction of TB PET systems\, the demand to develop image reconstruction s oftware that can support these complex systems was felt due to the signifi cant differences between these systems and current clinical tomographs.\nI n addition to the cases mentioned above\, in TB J-PET\, due to the utiliza tion of dual-layer configuration and large AFOV\, most of the image recons truction software are not able to support it.\nThe Medisip group developed QETIR (Quantitative Emission Tomography Iterative Reconstruction) at Gent University as a flexible software that has overcome the existing challeng es in TB PETs image reconstruction.\nThe main aim of this study is to inve stigate the performance of QETIR image reconstruction software in J-PET sc anners with different AFOVs\, and single and multi-layer configurations.\n \nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/767/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/767/ END:VEVENT BEGIN:VEVENT SUMMARY:Dose distribution comparison of cerebrospinal axis irradiation. He lical Tomotherapy vs. Proton Pencil Beam Scanning DTSTART;VALUE=DATE-TIME:20220714T094000Z DTEND;VALUE=DATE-TIME:20220714T100000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-701@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Bartosz Kiełtyka\; The University Hospital in Krako w\, Poland ()\nBackground\nRadiotherapeutic treatment performed in cerebro spinal axis becomes more common in oncological practice. Central nervous s ystem (CNS) malignant tumors are diagnosed in 1-2% of all adult patients. Most cases are regarding brain tumors in which a combined treatment is a s tandard of care: surgical resection\, radiotherapy (RT) and chemotherapy ( CHT).\nIn clinical practice\, the most frequent techniques in external bea m RT are related to dynamic techniques based on a standard medical acceler ator. The treatment is prepared in fractionation scheme 1.8-2.0 Gy / fract ion in 25-30 fractions.\nRecently\, tomotherapy is used to irradiate long and symmetrical types of structures\, however published clinical results a re sparse. Proton beam irradiation (PBI) is another treatment mode althoug h less available in most countries.\nThe aim of this study is to compare d ose distributions in treatment plans for the cerebrospinal axis irradiatio n using photon and proton techniques.\n\nMaterial and methods\nThe aim of the study is to compare dose distributions in treatment plans for the cere brospinal axis irradiation. Photon and proton techniques were used to prep are RT plans. To create a photon tomotherapy plan in helical technique imp lemented on the Radixact apparatus\, a treatment planning system (TPS) Pre cision\, Accuray\, was used. In case of proton RT planning\, TPS Eclipse ( Varian) was used in scanning beam mode.\nIn this study\, six treatment cas es were analyzed. In both mentioned techniques the same tomographic scans and contours of the critical organs (RT Structures) were used for treatmen t plan preparation. used for Then the comparison of prepared plans was per formed on RayStation\, RaySearch Laboratories software.\nDose distribution s in the target and critical organs were analyzed in terms of uniformity\, maximum\, average\, minimum dose for target and integral dose. The high d ose gradient areas that represent the resilience of treatment plans to unc ertainties related to patient positioning and organ mobility were also inv estigated. The technique of proton radiotherapy requires joining the field s. Field joints were subjected to deep analysis. Duration of treatment was also compared.\n\nResults and conclusions\nThe dose distributions obtaine d in proton plans are much more favorable in terms of the protection of cr itical organs and the integral dose reduction\, which is very important in case of pediatric patients reducing the risk of secondary cancer inductio n. On the other hand\, the treatment plans prepared for the photon helical technique are characterized by a greater dose distribution homogeneity in the areas where fields needed to be joined in proton techniques. Those ph oton plans were proved to be less sensitive to errors resulting from the g eometry of the patient's position. For both techniques similar irradiation times were obtained. Each technique has its own benefits and depending on availability might be applied in the treatment of adult CNS malignant tum ors.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/701/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/701/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: PET-MRI nanotheranostics with radio-labelled nanoparticl es DTSTART;VALUE=DATE-TIME:20220714T120000Z DTEND;VALUE=DATE-TIME:20220714T122500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-702@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Zdenka Kuncic\; University of Sydney\, Australia ()\ nIn radiation oncology and nuclear medicine\, the efficacy of theranostic strategies (i.e. combining treatment with diagnostic imaging) may be drama tically improved by leveraging the unique properties of nanoparticles. Due to their nanoscale size\, nanoparticles can penetrate target tissues and tumour cells\, and enhance physico-chemical reaction rates. In this talk\, I will discuss the opportunities presented by superparamagnetic nanoparti cles\, which\, when labelled with suitable radioisotopes\, offer a means f or realising PET-MRI theranostics. I will present results on a novel chela te-free technique for radio-labelling superparamagnetic nanoparticles with clinically relevant isotopes and discuss how such nanoparticles can impro ve the overall image quality of PET-MRI. I will also discuss how radio-lab elling superparamagnetic nanoparticles with therapeutic isotopes presents an opportunity for enhancing internal targeted radiotherapy by leveraging MRI guidance and nanoparticle radio-enhancement effects.\n\nhttps://indico .koza.if.uj.edu.pl/event/7/contributions/702/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/702/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Compartmental models – a useful tool for medical t herapy and diagnosis DTSTART;VALUE=DATE-TIME:20220714T122500Z DTEND;VALUE=DATE-TIME:20220714T124500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-704@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Aleksandra Jung\; AGH University of Science and Tech nology\, Poland ()\nAmong many computational methods\, compartmental model s are still attractive for many applications in medicine\, both in the fie lds of therapy and diagnosis. Below relevant examples are presented\, they are based on literature and own research results.\n\nKinetics models base d on differential equations are common for dose estimation in extracorpore al therapies. Hemodialysis adequacy considers methods based on experimenta l data providing to different measures like Kt/V or equivalent renal funct ion. This can be improved by adding additional dialysis adequacy indices t ested by numerical simulations. Mathematical models may accurately reprodu ce the clinical data of adequacy markers like urea or creatinine. In extra corporeal liver support therapies (ELS) considerable efforts focus on dose parameter estimation\, correct identification of compartment volumes and transfer coefficients parameters. A limited amount of clinical data in thi s case can be resolved by combined models of kinetics of the two substance s: bilirubin and urea. Building new models for ELS may also be partially s upported by the use of physiological models of bile acid kinetics previous ly described in the literature.\n\nThe outcome of the model depends on its structure\, parameters and initial conditions. Therefore\, it is necessar y to investigate the sensitivity of applied parameters\, especially when t he number of observation points is limited as it facilitates to decide the sampling rate in clinical practice. The accuracy of the parameter estimat ion may be improved if the sampling time is selected individually for each patient near the peak values of the sensitivity. This is beneficial both for the individualization of therapy assessment for a single patient and f or the preparation of a new complete clinical trial protocol.\n\nCompartme nt models describing the kinetics of radiolabeled substances are successfu lly used to support PET and SPECT imaging diagnostics where radiopharmaceu ticals are used routinely. The results of the mathematical model allow\, i n this case\, to obtain additional detailed diagnostic information. Models are also useful for comparing the diagnostic value of PET and SPECT tests \, for distinguishing malignant neoplasms from inflammations or other beni gn changes\, for assessing the diagnostic value of new radiopharmaceutical s or for assessing the impact of disturbances on the results of estimated physiological parameters. Additionally\, they are applied to evaluate the results of magnetic resonance imaging or to differentiate the severity of Helicobacter pylori infection based on the result of a C-14 labeled urea b reath test.\n\nLast but not least\, a clinically important area of applica tion of this type of models is the assessment of radiological exposure dur ing radiopharmaceutical exams\, but also in the assessment of the accumula tion of selected elements in our body\, e.g. lead.\n\nIn each of the above -mentioned applications\, the key is to define the initial assumptions and to properly adjust the complexity of the model to the amount of available experimental data and then to verify the model. Despite their limitations compartmental models can be used to identify meaningful physiological par ameters helpful in making the correct diagnosis or selecting the appropria te therapeutic dose.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contribut ions/704/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/704/ END:VEVENT BEGIN:VEVENT SUMMARY:Mesoporous silica carriers for controlled drug release DTSTART;VALUE=DATE-TIME:20220714T124500Z DTEND;VALUE=DATE-TIME:20220714T130500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-705@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Radek Zaleski\; Maria Curie-Skłodowska University\, Poland ()\nOne of the most important challenges in modern medicine is to ensure the desired course of delivery of active pharmaceutical ingredients (APIs) to the patient’s body. Therefore\, many studies are devoted to n ew delivery systems that can control both rate and period of drug delivery as well as the place of their administration. An important factor to cons ider when designing controlled release systems is the solubility of the AP I in the aqueous environment. Using an appropriately designed carrier allo ws to control the infiltration of the dissolving medium into the system\, resulting in a modification of the release of API. Among others\, the carr iers suitable for achieving this goal are porous matrices\, in which a sol id dispersion of the drug is formed.\nThe ordered mesoporous silica SBA-15 (carrier) and diclofenac sodium (API) were used to develop a controlled d rug release system. The release rate of diclofenac sodium was tested in vi tro to evaluate the suitability of this system for API release control. Fo r tabletted SBA-15\, it was possible to achieve a release course close to the desired linear release profile with release of about 50% API after 24 hours.\nFurther improvement of the release system requires insight into th e course of API release through its detailed study. The distributions of d iclofenac sodium within the carrier were studied for systems before releas e and after various release times. Scanning electron microscopy (SEM) coup led with energy dispersive spectroscopy (EDS) was used to determine the mo rphology and the spatial distribution of the elements. Free volumes rangin g in size from angstroms to nanometers were characterized with nitrogen ad sorption and positron annihilation lifetime spectroscopy (PALS). The resul ts obtained with these techniques allow to infer how the microstructure of the carrier-API system influences the drug release.\n\nhttps://indico.koz a.if.uj.edu.pl/event/7/contributions/705/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/705/ END:VEVENT BEGIN:VEVENT SUMMARY:Calibration of Silicon Drift Detectors for the SIDDHARTA-2 Experim ent DTSTART;VALUE=DATE-TIME:20220712T081700Z DTEND;VALUE=DATE-TIME:20220712T081900Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-734@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Aleksander Khreptak\; National Laboratory of Frascat i (LNF)\, Italy ()\nAuthor: Aleksander Khreptak\n\nThe main aim of the SID DHARTA-2 experiment at the DAΦNE collider in the LNF-INFN (Italy) is to p erform the high precision measurement of the kaonic deuterium exotic atom\ , which is formed when a negatively charged kaon (K−) is captured in a h ighly atomic excited state\, replacing an electron [1\,2].\n\nTo achieve t his goal\, a large area Silicon Drift Detectors (SDDs) system has been dev eloped by the SIDDHARTA-2 Collaboration [3]. The energy response of each d etector should be calibrated and monitored to reduce the systematic error (to the level of 2-3 eV).\n\nThe poster will present a calibration method for the SIDDHARTA-2 setup [4]\, which should guarantee high precision spec troscopic performances of the system during the data taking.\n\n[1] M. Mil iucci et al.\, Il Nuovo Cimento 44 C (2021) 152.\n[2] C. Curceanu et al.\, Few-Body Syst. 62 (2021) 83.\n[3] M. Miliucci et al.\, Meas. Sci. Technol . 32 (2021) 095501.\n[4] F. Sgaramella et al.\, arXiv:2201.12101 (2022).\n \nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/734/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/734/ END:VEVENT BEGIN:VEVENT SUMMARY:Unsupervised learning for pixel mask clustering and cluster tracki ng in LHCb’s Velopix sensor calibration DTSTART;VALUE=DATE-TIME:20220714T135500Z DTEND;VALUE=DATE-TIME:20220714T141000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-706@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Maciej Majewski\; AGH University of Science and Tech nology\, Poland ()\nThe VELO detector is one of the core elements of the L HCb spectrometer. Its1\nupcoming upgrade will consist of a new type of Vel opix sensor. It branches from a2\nMedipix family of silicon pixel matrix s ensors. One of its operational challenges3\nwith future data taking at the Large Hadron Collider will be the ability to detect4\nfaulty (masked) pix els and monitor them. In this work\, we propose a method for5\nclustering the faulty pixels and tracking the progression of the clusters in time. We 6\ncompare two methods of clustering (DBSCAN and OPTICS) and their influen ce7\non the proposed tracking method\, using a simulated dataset of masked pixels.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/706/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/706/ END:VEVENT BEGIN:VEVENT SUMMARY:3D printed lightweight and modular lithium-ion Uninterruptible Pow er Booster for medical devices DTSTART;VALUE=DATE-TIME:20220714T141000Z DTEND;VALUE=DATE-TIME:20220714T142500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-708@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Gabriel Moskal\; Jagiellonian University\, Poland () \nAdvanced devices for diagnostics and medical therapy require a constant and stable power source. The disadvantage of commonly used uninterruptible power supply (UPS) is the heavy weight[1]\, centralization and the need t o use specially prepared rooms and dedicated electrical installations. The aim of the presented research is to prepare a safe\, economic and modular Uninterruptible Power Booster (UPB). A UPB can increase the insufficient power output of the mains supply\, guaranteeing power for the pre-planned time. Low price and modularity are possible due to the use of 3D printing and Li-ion cells\, which will allow the construction of UPB installed in t he immediate vicinity of the protected device. Among available technologie s of chemical energy storage\, Li-ion cells are characterized by high grav imetric and volumetric energy density[1]. Currently\, liquid electrolytes( LE) are used in Li-ion cells\, which have good ionic conductivity\, but ar e flammable\, toxic and sensitive to lithium dendrite overgrowth\, which m ay lead to an internal short circuit and damage to a given module. For saf ety reasons\, a much better solution than LE would be solid electrolytes(S E)\, which would not be flammable and hazardous to the environment. Due to the fact that SE constitute a barrier to lithium dendrites\, they can ext end the working time of li-ion cells[2]. Currently\, there is no known mat erial that would fit well as a SE for li-ion cells. There are several mate rials under development\, but they are not ready for industrial applicatio ns[3\,4].This presentation concerns the research conducted on SE\, synthes ized with the use of cheap\, environmentally safe materials. For this purp ose\, syntheses of materials based on silicon glass and polysaccharides we re performed. Methods of syntheses and the results for measuring the ionic conductivity of the tested electrolytes and an example UPB for J-PET mobi le tomograph will be presented[5\,6]. The use of this solution with statio nary devices will allow to reduce electricity costs by loading the energy storage using a less expensive night tariff\, and then using the collected energy during the day\, and also to install the device in a room without access to a UPS system.\n[1]S. Anuphappharadorn Et al.\, “Comparison the economic analysis of the battery between lithium-ion and lead-acid in PV stand-alone application” Energy Procedia\,56(2014)352-358\n[2]J. Xie\, Y . Lu\, “A retrospective on lithium-ion batteries” Nature Communication s\,11(2020)2499\n[3]F. Zheng Et al.\,” Review on solid electrolytes for all-solid-state lithium-ion batteries” Journal of Power Source\,389(2018 )198-213\n[4]A. Manthiram Et al.\, “Lithium battery chemistries enabled by solid-state electrolytes” Nature Reviews Materials\,2(2017)16103\n[5] P. Moskal\, E. Stępień\, “Prospects and Clinical Perspectives of Total -Body PET Imaging Using Plastic Scintillators” PET Clinics\,15(2020)439- 452\n[6]P. Moskal et al.\, “Positronium in medicine and biology” Natur e Reviews Physics\,1(2019)527-529\n\nhttps://indico.koza.if.uj.edu.pl/even t/7/contributions/708/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/708/ END:VEVENT BEGIN:VEVENT SUMMARY:Application of the PALS technique in the investigation of the nano structure of enzymatic biosensor matrices for biomarkers detection in medi cal diagnostics DTSTART;VALUE=DATE-TIME:20220712T082100Z DTEND;VALUE=DATE-TIME:20220712T082300Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-736@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Magdalena Goździuk\; Maria Curie-Skłodowska Univer sity\, Poland ()\nAuthor: Magdalena Goździuk\nCo-authors: Bożena Zgardzi ńska\, Taras Kavetskyy\n\nBiosensors are devices widely used in many fiel ds of medicine. Using biosensors we can detect biomarkers of pathological states. One of very popular biosensor types are enzymatic biosensors. The biggest advantage of enzymatic biosensor is detection of specific molecule s depending on the enzyme used which is associated with the absence of fal se positives. Sensors of this type are characterized by high sensitivity a nd selectivity. Enzymatic biosensors have a matrix which improves biosenso r detecting abilities and immobilize an enzyme. Matrices can be produced f rom many types of materials e.g. gel\, carbon nanotubes\, chitosan\, nanow ires\, polymers etc.\nWe use Positron Annihilation Lifetime Spectroscopy t o investigate nanostructure of biosensors biopolymer matrices based on soy bean oil. The matrices are the part of amperometric enzymatic biosensors. The advantage of using polymer matrices is their low resistance so they do not interfere with the detection mechanism. The second important issue is good liquid sorption to a matrix to get better sensitivity. Soybean- oil based matrices were investigated in wide range of temperatures (120 K÷320 K) to determine the phase transitions in samples and analyze nanostructur e changes due to temperature. The next stage of research was sorption/ des orption using deionized water\, NaCl solution and polluted water. Using PA LS we can forecast matrix properties used in biosensor construction basing on ortho-Positronium lifetimes (τ3) and intensities (I3) changes under g iven humidity conditions and correlate results received using other invest igation methods.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions /736/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/736/ END:VEVENT BEGIN:VEVENT SUMMARY:The charm of charm DTSTART;VALUE=DATE-TIME:20220714T142500Z DTEND;VALUE=DATE-TIME:20220714T144000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-709@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jakub Ryżka\; AGH University of Science and Technol ogy\, Poland ()\nThe existence of CP violation in charm particle decays ha s been elusive for a long time for experimentalists and has been observed for the first time in 2019 in the LHCb experiment. During the LHC Run 1 an d Run 2\, the LHCb collaboration collected huge data samples on a scale ne ver seen before. These data enable the most sensitive searches for CP viol ation ever performed. These measurements are interpreted as precise tests of the Standard Model. In the presentation\, the latest results achieved i n charm decays will be reviewed and two innovative model-independent techn iques (Kernel Density Estimation and Energy test) for searching for CP vio lation in charm baryons will be discussed.\n\nhttps://indico.koza.if.uj.ed u.pl/event/7/contributions/709/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/709/ END:VEVENT BEGIN:VEVENT SUMMARY:129m\,131m\,133mXe – for gamma-MRI\, a novel medical imaging tec hnique DTSTART;VALUE=DATE-TIME:20220714T145500Z DTEND;VALUE=DATE-TIME:20220714T151000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-711@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Mateusz Chojnacki\; CERN\, Switzerland ()\nGamma-MRI is a future imaging modality that should allow the simultaneous exploitat ion of the sensitivity of gamma-ray detection (SPECT) and the spatial reso lution and flexibility of MRI [1]. The approach uses\, like in SPECT\, gam ma-emitting nuclei\, which are highly polarized and thus exhibit anisotrop ic gamma-ray emission\, whereas their spins are rotated by rf pulses\, lik e in MRI. The signal in gamma-MRI is the change in the ratio of gamma rays emitted longitudinally and transversally to the spin (and magnetic field) direction [2]. The first nuclei used in the project are 11/2− spin isom ers 129mXe (T1/2=8.9 days)\, 131mXe (T1/2=11.8 days) and 133mXe (T1/2= 2.2 days).\n\nThe efficient production and purification of the 129m\,131m\,133 mXe is one of the first milestones in the gamma-MRI project. This contribu tion will present two main methods of production tested so far: neutron ir radiation of enriched stable 128Xe (product: 129mXe) and 130Xe (product: 1 31mXe) in the RHF reactor at Intitute Laue-Langevin (ILL\; Grenoble\, Fran ce) and at the MARIA reactor in the National Centre for Nuclear Research ( NCBJ\; Świerk\, Poland)\, and ion-implantation of 129m\,131m\,133mXe into gold foils at the ISOLDE facility in CERN (Switzerland). Both methods pro vide high values of xenon isotopes activities that can be extracted effici ently and used in polarization experiments.\n\nThe presentation will give a brief introduction to the gamma-MRI technique and will mention the diffe rent elements of this EU-funded project. It will then concentrate on the w ork performed at the CERN\, namely production and purification of the Xe i somers.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/711/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/711/ END:VEVENT BEGIN:VEVENT SUMMARY:Preliminary results of determining Modular J-PET spatial resolutio n DTSTART;VALUE=DATE-TIME:20220714T144000Z DTEND;VALUE=DATE-TIME:20220714T145500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-710@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Faranak Tayefi Ardebili\; Jagiellonian University\, Poland ()\nModular J-PET is the latest prototype of the Jagiellonian-PET\, based on long plastic scintillator strips [2]. The modularity of this pro totype allows for cost-effective imaging of multi-photon annihilation and positronium imaging\, straightforward assembly\, and portability [1-3]. Mo reover\, due to the low weight of a scanner\, it is possible to perform an examination with a static bed and mobile detection system closing on the patient from its side\, which cancels the need for large rooms in clinics [1-3].
\nThe Modular J-PET consists of 24 modules which are arranged in regular 24-sided polygons circumscribing a circle with a diameter of 73.9 cm [4]. Each module was built out of 13 scintillator strips placed next to each other with a length of 50 cm and a cross-section of 6 mm × 24 mm\, read out of scintillation light on both ends is done by an analog Silicon Photomultipliers (SiPMs). This study presents preliminary results of the s patial resolution measurement of the Modular J-PET tomograph performed wit h Na source placed at various positions inside the detector according to t he NEMA_NU 2-2018 standards [5]. The collected data were analyzed using a specialized software program called the J-PET Framework\, which is based o n the C++ architecture [6]. Experimental data were verified with the GATE simulations [7]. In simulations of the Modular J-PET spatial resolution\, a back-to-back gamma source was simulated in the same position as used in the experiment [8]. The results of the simulation were reconstructed with the QETIR package.\n\nAcknowledgments:\nThe authors acknowledge support by the TEAM POIR.04.04.00-00-4204/17 program\, the NCN grant no. 2021/42/A/S T2/00423 and the SciMat and qLife Priority Research Areas budget under the program Excellence Initative - Research University at the Jagiellonian Un iversity.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/710/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/710/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: 10ps Time-of-Flight PET scanner: From Hope to Practice DTSTART;VALUE=DATE-TIME:20220715T070000Z DTEND;VALUE=DATE-TIME:20220715T072500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-712@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Paul Lecoq\; CERN\, Switzerland ()\nThe future gener ation of radiation detectors is more and more demanding on timing performa nce for a wide range of applications\, in particular for time-of-flight (T OF) techniques in PET cameras.\nThere is in particular a consensus for gat hering Europe's multi-disciplinary academic and industrial excellence arou nd the ambitious challenge to develop a 10 ps TOF PET scanner (TOFPET). Th e goal is to reduce the radiation dose (currently 5-25 mSv for whole body PET/CT)\, scan time (currently > 10 minutes)\, and costs per patient (curr ently > 1000 € per scan)\, all by an order of magnitude. To achieve this very ambitious goal it is essential to significantly improve the performa nce of each component of the detection chain: light production\, light tra nsport\, photodetection\, readout electronics.\nThe possibility to reach 1 0 ps time-of-flight resolution at small energies\, as required in PET scan ners\, although extremely challenging\, is not limited by physical barrier s.\nThis talk will show how progress in nanotechnologies open new perspect ives for the development of meta-scintillators\, a new class of multifunct ional multi-intelligent scintillators.\nIndeed\, a number of disruptive te chnologies\, such as multifunctional heterostructures\, combining the high stopping power of well know scintillators with the ultrafast photon emiss ion resulting from the 1D\, 2D\, or 3D quantum confinement of the excitons in nanocrystals\, photonic crystals\, photonic fibers\, as well as new co ncepts of 3D digital SiPM structures\, open the way to new radiation detec tor concepts with unprecedented performance.\n\nhttps://indico.koza.if.uj. edu.pl/event/7/contributions/712/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/712/ END:VEVENT BEGIN:VEVENT SUMMARY:Optimization study of a muon tomography system for imaging of nucl ear waste containers DTSTART;VALUE=DATE-TIME:20220715T072500Z DTEND;VALUE=DATE-TIME:20220715T074500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-713@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Anzori Georgadze\; Kiev Institute for Nuclear Resear ch\, Ukraine ()\nThe important parameters of nuclear waste have to be dete rmined for its classification and selection of optimal disposal option. Fo r the non-destructive characterization of nuclear waste muon scattering to mography techniques can be used to image the contents of an enclosed volum e by measuring the scattering angle of cosmic ray muons as they pass throu gh a nuclear waste container using particle tracking detectors. In this pa per we present an optimization study of a muon tomography detector to obta in its parameters for best performance. Using Geant4 combined with Cosmic- ray shower generator (CRY) we have studied two detector geometries to comp are their efficiency of detection and reconstruction of high-Z materials. One of detector design consist of muon two tracking detectors placed on to p and bottom sides of nuclear waste container and another one represents c losed up design when muon trackers are surrounding container from four sid es. The results of POCA reconstruction of 10 cm cubic size object of high- Z material encapsulated in a concrete matrix indicate that detector design with tracking detectors on four sides around container demonstrate slight ly better performance comparing to detector design with two tracking detec tors on top and bottom. On the other hand\, tomography system with muon tr ackers on top and bottom sides can be more universal allowing changing the distance between planes and measuring nonstandard nuclear waste.\n\nhttps ://indico.koza.if.uj.edu.pl/event/7/contributions/713/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/713/ END:VEVENT BEGIN:VEVENT SUMMARY:Comparative studies of plastic scintillator strips with high techn ical attenuation length for the total-body J-PET scanner DTSTART;VALUE=DATE-TIME:20220715T074500Z DTEND;VALUE=DATE-TIME:20220715T080500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-714@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Łukasz Kapłon\; Jagiellonian University\, Poland ( )\nŁ. Kapłon 1\, 2\, 3\, on behalf of the J-PET Collaboration\n\n1 Facul ty of Physics\, Astronomy and Applied Computer Science\, Jagiellonian Univ ersity\, Krakow\, Poland\n2 Total-Body Jagiellonian-PET Laboratory\, Jagie llonian University\, Krakow\, Poland\n3 Center for Theranostics\, Jagiello nian University\, Krakow\, Poland\n\nCorresponding author: lukasz.kaplon@u j.edu.pl\n\nPlastic scintillators are used in many applications connected with advanced medical devices\, for example in novel multiphoton J-PET sca nners with positronium imaging capability [1\, 2]\, and in plastic scintil lation dosimetry [3].\n\nIn the first part of the lecture\, results from m easurements of transparency of commercially available plastic scintillator s will be presented [4]. Purpose of the research is to select the best typ e of scintillator for the total-body J-PET scanner construction. Emission spectra\, transmission spectra and technical attenuation length (TAL) valu es of six types of plastic scintillators with dimensions 6 mm × 24 mm × 1000 mm will be discussed. General purpose\, blue-emitting plastic scintil lators with low attenuation of visible light were tested: polyvinyl toluen e-based BC-408\, EJ-200\, RP-408 and polystyrene-based Epic\, SP32 and UPS -923A. The emission spectra of the investigated scintillators have maxima ranging from 420 nm to 429 nm. The BC-408 and EJ-200 scintillators have th e highest transmittance values of about 90% at the maximum emission wavele ngth (measured through a 6 mm thick scintillator) and the highest TAL valu es up to about 200 cm\, allowing building of long modules for total-body J -PET scanner.\n\nIn the second part of the talk\, results from the researc h of blue- and green-emitting polystyrene-based plastic scintillators for scintillation dosimetry applications will be presented [5]. Anthracene\, c oumarin and perylene fluorescent dyes were used as wavelength shifters [6] . Emission maxima of manufactured green-emitting polystyrene scintillators are in range from 484 to 525 nm. The concentrations of the BPBD ultraviol et dye and Solvent Green 5 green fluorescent dye\, influence the light out put\, rise and fall times\, and the emission spectra of the scintillator s amples.\n\nReferences:\n[1] P. Moskal\, E. Stępień\, PET Clinics 15 (202 0) 439-452\n[2] P. Moskal et al.\, Science Advances 7 (2021) eabh4394\n[3] S. Beddar et al.\, 12th chapter in: M. Hamel (Ed.)\, Plastic Scintillator s. Springer 2021\n[4] Ł. Kapłon\, IEEE Transactions on Nuclear Science 6 7 (2020) 2286-2289\n[5] Ł. Kapłon\, G. Moskal\, Bio-Algorithms and Med-S ystems 17 (2021) 191–197\n[6] Ł. Kapłon\, G. Moskal\, Submitted to Opt ical Materials: X (2022).\n\nThis work was supported by grant for the earl y stage of research financing from Centre for Technology Transfer CITTRU f rom the Jagiellonian University in 2021\; the Priority Research Area DigiW orld under the program Excellence Initiative Research University at the Ja giellonian University in 2021\; the National Science Centre of Poland thro ugh grant OPUS No. 2019/35/B/ST2/03562\, and the Jagiellonian University u nder project No. CRP/0641.221.2020. The authors acknowledge support by the TEAM POIR.04.04.00-00-4204/17 program\, the National Science Center grant no. 2021/42/A/ST2/00423 and the SciMat and qLife Priority Research Areas budget under the program Excellence Initiative - Research University at th e Jagiellonian University.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/con tributions/714/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/714/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: PET/CT and SPECT/CT in preclinical research: Systems and applications DTSTART;VALUE=DATE-TIME:20220715T083500Z DTEND;VALUE=DATE-TIME:20220715T090000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-715@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Sibylle Ziegler\; Ludwig-Maximilian University of Mu nich\, Germany ()\nPET and SPECT are truly translational since the same me thods can be applied in animals and in clinical studies. Owing to the smal l structures\, dedicated instrumentation is needed for mouse and rat imagi ng\, while large animal models can be investigated using clinical systems. Some new detector concepts have been introduced first in preclinical syst ems before scaling up to clinical systems. Biodistribution and biokinetics of novel radioactively labelled tracers are studied in rodents before tra nslating into patient use. Multi-tracer longitudinal measurements can be p erformed for characterizing disease models or assessing the effect of inte rventions. In addition\, similar quantitative image analysis methods can b e applied in preclinical models before translating to the clinical case.\n In this presentation\, an overview on specific instrumentation for animal imaging will be given\, together with examples of preclinical imaging stud ies performed in our lab with specific focus on specific tracer applicatio ns in neurology and beta-cell transplant research.\n\nhttps://indico.koza. if.uj.edu.pl/event/7/contributions/715/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/715/ END:VEVENT BEGIN:VEVENT SUMMARY:Relevance of Monte Carlo simulation validation analysis in the sco pe of the Dose-3D project DTSTART;VALUE=DATE-TIME:20220712T084900Z DTEND;VALUE=DATE-TIME:20220712T085100Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-770@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Wioleta Górska\; AGH University of Science and Tech nology\, Poland ()\nAuthors: Wioleta Górska\, DOSE-3D Collaboration\n\nRa diotherapy aims to deliver a specific dose of radiation to the treated are a\, destroying the tumour. Thanks to the use of newer technologies and the ir continuous development\, it is possible to very precisely deliver the p lanned doses of radiation to the treated areas\, while reducing the exposu re of healthy tissues to radiation. Undoubtedly\, physical simulations and the use of algorithms supporting the work of medical physicists contribut ed to the improvement of the quality of treatment. Due to their advantages \, MC simulations are used both in the area of treatment planning and scie ntific research. However\, to obtain reliable calculation results\, it is necessary to previously validate the MC simulations\, concerning experimen tal and reference data. This milestone has been already achieved in the sc ope of the Dose-3D project and this presentation is aimed to present its s ummary.\nThe Dose-3D project is a novel reconfigurable detector intended f or a full spatial therapeutic dose reconstruction to improve radiotherapy treatment planning. The main challenge of the project is the construction of a 3D measurement matrix. One of the crucial challenges is the developme nt of high-quality software for dose simulation\, configuration and contro l of the entire device\, and data analysis. A key issue in the research wi ll be to obtain a high agreement between the simulated dose distributions and those measured during the detector tests. For this purpose\, The GEANT 4-RT simulator platform was assembled. The implementation of a reliably fu nctioning platform using the GEANT4 engine to simulate the interaction of radiation with matter is crucial for the success of the entire project.\nT o verify the reliability of the modelled Varian Clinac 2300 C/D medical li near accelerator head and used physics model in the GEANT4-RT the spatial dose distributions were calculated and then correlated with the respective measurements provided by The Maria Sklodowska-Curie National Research Ins titute of Oncology in Krakow. The comparisons were conducted using a varie ty of methods including the common and standard verification approaches us ed in clinical practice like dose difference analysis and gamma test. The validation was extended by comparison with the results generated by Penelo pe engine based MC simulator - PRIMO\, whose reliability was verified in a ddition to Geant4-RT scope of studies. Once the geometry specification of linac’s is not publicly available we rely on the linac model defined in the PRIMO simulator. Extracting phaspace for the given beam model from PRI MO we continued simulation in GEANT4-RT application including field modell ing here.\nFurthermore\, MC simulation allows for physics model specificat ions and tuning values correlated with it like production cut. For this re ason\, it is necessary to verify the reliability of selected configuration s. To execute such validation\, an analysis of the photon interactions in the water phantom was performed.\nIn conclusion\, MC simulation platform w ithin the Dose-3D project has been initialised and verified as the in-hous e application for further development for reconfigurable scintillator phan tom purposes.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/77 0/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/770/ END:VEVENT BEGIN:VEVENT SUMMARY:Proteomic profiling of extracellular vesicles derived from pancrea tic beta-cells cultured under hyperglycemia DTSTART;VALUE=DATE-TIME:20220715T094500Z DTEND;VALUE=DATE-TIME:20220715T100500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-717@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Carina Rząca\; Jagiellonian University\, Poland ()\ nCargo carried by extracellular vesicles (EVs) is considered as a promisin g diagnostic marker\, especially proteins [1\,2]. EVs can be divided accor ding to their size and way of biogenesis into exosomes (diameter <200 nm) and ectosomes (diameter <200 nm) [1].\nFirst step of this study was charac terization of EVs sample [2]. Using Tunable Resistive Pulse Sensing (qNano ) size distribution and concentration were measured. The mean size of exos omes was 135±15 nm\, and ectosomes 210±17 nm. TEM images also confirmed the size of EVs and the purity of prepared samples. In the present study\, a nano liquid chromatography with tandem mass spectrometry (nanoLC-MS/MS) was used to profile and compare the protein content of ectosomes and exos omes secreted by pancreatic beta cells (1.1B4) grown under NG (5 mM D-gluc ose) and HG (25 mM D-glucose) conditions. The EVs samples were lysed\, and proteins were denaturated\, digested\, and analyzed using a Q-Exactive ma ss spectrometer coupled with the UltiMate 3000 RSLC nano system (Thermo Fi sher Scientific) The LC-MS/MS data were searched against SwissProt Homo sa piens database using MaxQuant software and protein quantitation was done b y the MaxLFQ algorithm. Statistical analysis was carried out with Perseus software. Further bioinformatic analysis was performed using the FunRich 3 .1.4 software with the UniProt protein database and STRING [3\, 4\, 5].\nA s a result of the tandem mass spectrometry analysis more than 1\,000 prote ins were identified and quantified in each sample. The average number of i dentified proteins in exosomes and ectosomes was 1\,397 and 1\,697\, respe ctively. Label-free quantitative analysis showed that exosome and ectosome protein composition differed significantly between those isolated under N G and HG conditions. Many pathways were down-regulated in HG\, particularl y the ubiquitin-proteasome pathway. In addition\, a significant up-regulat ion of the Ras-proteins pathway was observed in HG.\nOur description of EV s protein content and its related functions provides the first insight int o the EV interactome and its role in hyperglycemia development and diabeti c complications. The results also indicate the applicability of some of th ese EVs proteins for further investigation regarding their potential as ci rculating in vitro biomarkers [6\, 7\, 8].\n\nReferences\n[1] Stępień E Ł\, et. al. Bio-Algorithms and Med-Systems 2021\;17\,4\; 301-309.\n[2] Ka mińska A\, PhD Thesis 2019\, Kraków\, WFAIS UJ.\n[3] Surman M\, et. al. International Journal of Molecular Science 2021\, 22(13)\, 6816.\n[4] Surm an M\, et. al. Cells 2022\, 11(7)\, 1184.\n[5] Surman M\, et. al. Proteome s 2019\, 7(2)\,21.\n[6] Stępień E\, et. al. Theranostics 2018\;8(14).\n[ 7] Stępień E\, et al. 2021\, Patent Nr: PAT.237810.\n[8] Stępien E\, et al. 2020\, Patent Nr: PAT.235682.\n\nhttps://indico.koza.if.uj.edu.pl/eve nt/7/contributions/717/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/717/ END:VEVENT BEGIN:VEVENT SUMMARY:Closing & Awards for The Best Poster and The Best Young Researcher Talk DTSTART;VALUE=DATE-TIME:20220715T100500Z DTEND;VALUE=DATE-TIME:20220715T103500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-718@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Prof. Paweł Moskal\, Prof. Ewa Stępień ()\nhttps: //indico.koza.if.uj.edu.pl/event/7/contributions/718/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/718/ END:VEVENT BEGIN:VEVENT SUMMARY:Measurement of correlation between polarization of annihilation ph otons emitted in e+e- system to detect entanglement at sub-MeV range DTSTART;VALUE=DATE-TIME:20220712T085300Z DTEND;VALUE=DATE-TIME:20220712T085500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-772@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Deepak Kumar\; Jagiellonian University\, Poland ()\n Author: Deepak Kumar\nCo-author: Sushil Sharma\n\nD. Kumar1\,2\,3\, S. Sha rma1\,2\,3 on behalf of the J-PET collaboration\n1Faculty of Physics\, Ast ronomy\, and Applied Computer Science\, Jagiellonian University\, Poland.\ n2Total-Body Jagiellonian-PET Laboratory\, Jagiellonian University\, Krak ów\, Poland\n3Center for Theranostics\, Jagiellonian University\, Cracow\ , Poland\ne-mail: d.kumar@doctoral.uj.edu.pl\n\nQuantum electrodynamics pr edicts that photons originating from the decays of e+e- annihilations are entangled and have mutually orthogonal linear polarization [1]. Since the polarization of the photons is orthogonal to each other\, correlation can occur in subsequent interactions. Compton scattering of photons can be use d as a polarization analyser to measure such correlations [2]. To measure the correlation between the scattered photon due to entanglement\, the two photons must be detected before and after the scattering [3]. Thanks to i ts unique geometry\, J- PET can be used as a potential detector to perform such studies in full phase space [4\,5\,6]. It consists of 192 plastic sc intillators with dimensions 50 x1.9 x 0.7cm3 (length x width x height) arr anged in 3 cylindrical layers with increasing radial distance 42.50 cm\, 4 6.75 cm and 57.5 cm\, respectively [4]. Photons interact mainly via the Co mpton effect inside plastic scintillators. Since an incident photon intera cting with the plastic scintillator is mostly scattered perpendicular to t he polarization direction of the incident photon\, the polarization of a s ingle photon is defined as the cross product of the momentum vectors of th e photon before and after scattering (ϵ=k ×k') [7].\nOur goal is to stud y the correlation between the polarization vectors of annihilation photons produced either by direct annihilation of electron and positron or by the formation of a positronium atom in the presence of a medium. In this pres entation\, the methodology to perform such studies in the framework of J-P ET detector and the preliminary results will be presented.\nThe authors ac knowledge support by the TEAM POIR.04.04.00-00-4204/17\nprogram\, the NCN grant no. 2021/42/A/ST2/00423 and the SciMat and\nqLife Priority Research Areas budget under the program Excellence\nInitiative - Research Universit y at the Jagiellonian University.\nReferences:\n[1] Snyder\, H. S.\, Paste rnack\, S. & Hornbostel\, J Phys. Rev.73\, 440 (1948)\n[2] O. Klein\, Y. N ishina\, Y. Z. Physik 52\, 853 (1929)\n[3] P. Moskal et al.\, Acta Phys. P olon. B 47\, 509 (2016)\n[4] S. Niedzwiecki et al.\, Acta Phys. Polon. B48 (2017) 1567\n[5] P. Moskal et al.\, Nature Communications 12. 5658 (2021) \n[6] P. Moskal et al.\, Science Advances\, Vol 7\, Issue 42\, Page No. 43 94 (2021)\n[7] P. Moskal et al. Eur. Phys. J. C 78\, 970 (2018).\n\nhttps: //indico.koza.if.uj.edu.pl/event/7/contributions/772/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/772/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Quantitative analysis of tumor hypoxia in nuclear me dicine imaging and therapy DTSTART;VALUE=DATE-TIME:20220711T092500Z DTEND;VALUE=DATE-TIME:20220711T094500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-655@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kuangyu Shi\; University of Bern\, Switzerland ()\nT umour hypoxia is a critical hallmark of cancer\, which is associated with tumour aggressiveness and resistance to multiple therapies. PET imaging me thods have been developed for noninvasive visualization of tumour hypoxia and the emerging radioligand therapy is expected to overcome the limitatio n of conventional external beam radiotherapy in cancer treatment. However\ , it is not straightforward to interpret the PET imaging signals for tumou r hypoxia due to the complex tumour microenvironment. On the other side\, the influence of hypoxia on radioligand therapy is more complex than the p enetration distance of therapeutic radioisotopes. This talk will give an o verview of computational methods including pharmacokinetic modelling and r eaction-diffusion modelling in the interpretation of hypoxia in PET imagin g and radioligand therapy. The combination of experimental data and comput ational modelling may accelerate the development of hypoxia-related nuclea r medicine imaging and therapy.\n\nhttps://indico.koza.if.uj.edu.pl/event/ 7/contributions/655/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/655/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Molecular imaging of human stem/progenitor cells for pro-regenerative purposese DTSTART;VALUE=DATE-TIME:20220711T090500Z DTEND;VALUE=DATE-TIME:20220711T092500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-580@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Maciej Kurpisz\; Institute of Human Genetics\, Polis h Academy of Sciences\, Poland ()\nWe have used human stem/progenitor cell s of myogenic origin (with mostly CD56+\, desmin-positive characteristics) either alone or together with mesenchymal stem cells (MSC) to be applied in the mouse post-infarction heart model (immunocmpromise SCID mice) when tracking them in situ in medium and long-term imaging system. In order to differentiate between myoblasts anbd MSC/s we have used two types of biolu minescent markers (firefly liciferase versus nanoluc) with two different m olecular promoters incorporated to the stem cells while delivering the cel ls intramyocardially to post-infarcted heart using four variants of cellul ar therapies. We have found by bioluminescent imaging that in a group of m ice with post-infarcted heart the highest signal was obtained when myoblas ts were applied together with MSC/s vs myoblasts alone (p<0.0001). This co uld be a promising strategy for pro-regenerative future clinical trials.Fo r a long cell imaging we additionally used [18F}-FHBG PET/CT model when ap plying stem cells with molecular double promoter/reporter sequence that co uld either link flushed 18F isotopes with FDG (fluorodeoxyglucose) for cel l viability. In vivo PET/CT and MRI revealed precise measurement of report er probes signaling incorporated into the cells for as long as 6 weeks of monitoring.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/580/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/580/ END:VEVENT BEGIN:VEVENT SUMMARY:Characterization of spheroid growth based on a new dynamical model DTSTART;VALUE=DATE-TIME:20220712T085500Z DTEND;VALUE=DATE-TIME:20220712T085700Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-774@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kamil Dulski\; Jagiellonian University\, Poland ()\n Authors: K. Dulski1\,2 and M. Szczepanek1\,2\n\n1Institute of Physics\, Ja giellonian University\, Kraków\, Poland\n2Center for Theranostics\, Jagie llonian University\, Kraków\, Poland\n\nCell cultures are a recognized mo del that helps understand interaction of cells with certain external facto rs\, such as radiation or drugs [1\,2]. In particular\, characterizing the growth of a given cell line for a different intensity of a therapeutic ag ent allows for non-invasive assessment of its effectiveness [1]\, and in s ome cases also for optimization of therapeutic conditions for cells of a g iven type [3\,4]. Currently\, there are two types of cell culture - 2D\, w here cells grow in a planar monolayer and 3D\, an example of which are sph eroids. 3D cultures are characterized by greater similarities to tumours i n the conditions occurring in the body. The common features between spher oids and tumours allow for a more complete understanding evaluation of the effectiveness of therapy [3-6]. \nCurrently\, the growth of biological sy stems is mainly described by logistic models\, most often with the Gompert z model [7\,8]. However\, this model does not always describe the experime ntal data perfectly\, and it also fails to characterize the cell line base d on parameters such as cell size\, nutrient consumption\, and separation zones of strongly dividing cells from zones with dead and non-dividing cel ls. A new\, dynamic model of spheroid growth will be presented\, allowing to characterize the above-mentioned parameters and additionally better ref lecting the spheroid growth curve. Additionally\, the simulations performe d using dedicated software allowed for a detailed characterization of the WM266-4 skin cancer cell line\, as well as for the theoretical visualizati on of the distribution of various zones inside the spheroid at different g rowth times.\n[1] D.A. Scudiero\, R.H. Shoemaker\, K.D. Paull et al.\, Eva luation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug S ensitivity in Culture Using Human and Other Tumor Cell Lines\, Cancer Res. 48 (1988) 4827-4833\n[2] M.F. Bernet\, B. Brassart\, J.R. Nesser and A.L. Servin\, Lactobacillus acidophilus LA 1 binds to cultured human intestina l cell lines and inhibits cell attachment and cell invasion by enterovirul ent bacteria\, Gut 35 (1994) 483-489\n[3] M. Zoetemelk\, M. Rausch\, D.J. Colin et al.\, Scientific Reports 9 (2019) 7103\n[4] M. Silarski\, K. Dzie dzic-Kocurek and M. Szczepanek\, Combined BNCT and PET for theranostics\, Bio-Algorithms and Med-Systems 17 (2021) 293-300\n[5] E.Ł. Stępień\, H. Karimi\, B. Leszczyński and M. Szczepanek\, Melanoma spheroids as a mode l for cancer imaging study\, Acta Phys. Pol. B 51 (2020) 159-163\n[6] M. S zczepanek\, Application of 3D model of cancer cellsin research on the effe ctiveness of BNCT in the treatment of melanoma\, Acta Phys. Pol. B 51 (202 0) 413-419\n[7] R.L. Buchanan\, R.C. Whiting\, W.C. Damert\, When is simpl e good enough: a comparison of the Gompertz\, Baranyi\, and three-phase li near models for fitting bacterial growth curves\, Food Microbiology 14 (19 97) 313-326\n[8] R. Omar\, M.A. Abdullah\, M.A. hasan\, M. Rosfarizan and M. Marziah\, Kinetics and modelling of cell growth and substrate uptake in Centella asiatica cell culture\, Biotech. Bioprocess Eng. 11 (2006) 223-22 9\n\nAcknowledgment\nThis work was supported by the Foundation for Polish Science through the MPD and TEAM/2017-4/39 programs\, the National Science Centre of Poland through grant nos. 2017/25/N/NZ1/00861\, 2019/35/B/ST2 / 03562 and 2021/41/N/ST2/03950\, the Jagiellonian University via project CR P/ 0641.221.2020\, and the SciMat Priority Research Area budget under the program Excellence Initiative-Research University at Jagiellonian Universi ty\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/774/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/774/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Nuclear Imaging in Infective Endocarditis DTSTART;VALUE=DATE-TIME:20220711T094500Z DTEND;VALUE=DATE-TIME:20220711T100500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-656@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Magdalena Kostkiewicz\; Nuclear Medicine Department\ , John Paul II Hospital\, Poland ()\nInfective endocarditis is a complex d isease with cardiac involvement and multiorgan complications. Its prognosi s depends on prompt diagnosis that leads to an aggressive therapeutic mana gement combining antibiotic therapy and early cardiac surgery when indicat ed. However\, IE diagnosis always poses a challenge. In recent years\, nuc lear imaging ( technetium99m hexamethylpropyleneamine oxime-labelled autol ogous leukocytes (99mTc-HMPAO-SPECT/CT) and 18FDG PET) have experienced si gnificant technical improvements\, and their application to the detection of cardiac and extracardiac IE-related lesions seems to be a strategic way forward in the management of patients with suspected IE. The accumulation of time-dependent radiolabelled leucocytes (99mTc-HMPAO-WBC) is registere d to evaluate in vivo inflammatory lesions. The main added value of this t echnique is its high specificity and detection of peripheral embolic event s. Sensitivity and specificity of 99mTc-HMPAO-SPECT/CT was 86% and 97%\, r espectively. Positron emission tomography with fluorodeoxyglucose (18F-FDG PET) technology delivers high-resolution images by the use of biologicall y active compounds labeled with positron emitters. Uptake of the radiophar maceutical in PET is based on the high expression of glucose transporters\ , which actively incorporate the tracer into the cells. A radiolabeled gly cogen analog accumulates into cells such as activated inflammatory cells i n infection and inflammation processes.Metabolic activity is evaluated bot h qualitatively and quantitatively. If PET/CT acquisition is combined with cardiac CT (PET/CT)\, the metabolic findings provided by the [18F]FDG upt ake distribution and intensity might be added to the anatomic findings alr eady described for cardiac CT within a single imaging procedure. Notable a dvantages of PET/CT and WBC SPECT/CT are their ability to perform the extr acardiac workup within a single imaging procedure and to reveal the concom itant presence of extracardiac infection sites as the consequence of both septic embolism and primary infective processes. Nuclear examination may p rovide opportunities for personalized evaluation in order to choose the be st therapeutic strategy.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contr ibutions/656/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/656/ END:VEVENT BEGIN:VEVENT SUMMARY:Development of a high-resolution PET detector for small animal in- beam PET system DTSTART;VALUE=DATE-TIME:20220712T085900Z DTEND;VALUE=DATE-TIME:20220712T090100Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-776@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Munetaka Nitta\; Ludwig Maximilians University\, Ger many ()\nAuthors: Munetaka Nitta\, Giulio Lovatti\, Kang Han Gyu\, Rohgieh Haghani\, Chiara Gianoli\, Georgious Dedes\, Andrea Zogular\, Yamaya Taig a\, Christoph Scheidenberger\, Marco Durante\, Peter Thirolf\, Katia Paodi \n\nWe have been developing a high resolution small in-beam PET system in the framework of the project “Small animal Irradiation for Research in M olecular Image-guided radiation Oncology (SIRMIO)”\, which is an EU-fund ed endeavor aiming to realize a prototype platform for accurate image-guid ed small animal proton irradiation at clinical facilities. In this project we plan to deliver a proton beam to the mouse tumor and monitor the posit ron emitters generated by the beam using a dedicated in-beam PET scanner. The PET scanner exhibits a unique spherical shape for high detection sensi tivity along with sufficient open space for accommodating the beam and int egrating additional beam monitoring detectors as well as a mouse holder. I n addition to that\, uniform sub-millimeter spatial resolution is required for accurate range verification. In order to achieve these requirements\, in a collaborative effort between LMU and QST\, we have developed a 3-lay ers depth-of-interaction (DOI) PET detector [1]. The PET detector is compo sed of LYSO scintillator pixels with 0.9 mm×0.9 mm×6.67 mm size read out by an 8×8 SiPM array. A charge division circuit is used to reduce the 64 signals of the SiPM array to 4 signals for an Anger calculation. 56 PET d etectors are embedded in a spherical housing frame.\nIn this study\, a poi nt source experiment was carried out to evaluate the spatial resolution of the PET scanner especially in the central region of the field of view and along beam axis. There\, we could achieve the targeted 1 mm spatial resol ution\, confirming satisfactory performance for our project. In addition t o that\, we will show the capability of our PET detector for high resoluti on radioactive ion beam imaging of C-11\, as explored in the context of th e EU-funded project “Biomedical Applications of Radioactive Beams” (BA RB).\n\nAcknowledgment\;\nThis work is funded by the European Research Cou ncil (ERC) under the European Union's Horizon 2020 research and innovation programme through the grant agreements number 725539 (SIRMIO\, PI K. Paro di) and 883425 (BARB\, PI M. Durante). The authors would also like to ackn owledge the support from the Bavaria California Technology Center (grant A 1 [2021-1]). Part of the results are based on an experiment carried out in the context of FAIR Phase-0 at GSI\, Darmstadt (Germany).\n\nReference\n[ 1] 2021\, Kang et al.\, BPEX\, vol 7\, no. 3\, pp. 035018\n\nhttps://indic o.koza.if.uj.edu.pl/event/7/contributions/776/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/776/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: Biomedical Applications of Radioactive ion Beams: First results of the BARB project at GSI DTSTART;VALUE=DATE-TIME:20220712T063000Z DTEND;VALUE=DATE-TIME:20220712T065500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-665@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Marco Durante\; GSI Darmstadt\, Germany ()\nHeavy io n particle therapy is a rapidly growing and potentially the most effective and precise radiotherapy technique. However\, range uncertainties remain one of its limitations: they jeopardize the benefits of the sharp Bragg pe ak and force to use wide margins extending in the normal tissue.\n\nThe us e of radioactive ion beams (RIBs) for simultaneous treatment and online ra nge verification using positron emission tomography (PET) could help overc oming this limitation\, due to increased signal/noise ratio and alignment of the activity peak with the Brag peak compared to PET imaging of fragmen ts produced by primary\, stable ions.\n\nIn this context\, the BARB (Biome dical Applications of Radioactive ion Beams) project was initiated at GSI aiming to assess the technical feasibility and investigate possible advant ages of RIBs in preclinical studies.\n\nDuring the first year of experimen ts within this project\, radioactive Carbon and Oxygen beams (10\,11C and 15O) were produced by isotopic separation with the fragment separator and transported to the medical vault of GSI. Thanks to the upgrade of the SIS- 18 in the FAIR in Darmstadt\, it was possible to achieve RIB intensities s ufficient to treat a small animal tumor.\n\nBeam implantation in plastic p hantoms was visualized by two independent imaging setups: a dual-panel PET scanner from the University Medical Center Groningen and a subset of a hi gh resolution small animal -PET detector in development at the Ludwig-M aximilians-Universität in Munich. Range and depth dose distributions meas urements have been performed with a water column setup. These first experi mental results will be presented.\n\nWork supported by ERC Advanced Grant BARB (2020\, Marco Durante)\n\nhttps://indico.koza.if.uj.edu.pl/event/7/co ntributions/665/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/665/ END:VEVENT BEGIN:VEVENT SUMMARY:Towards improving the sensitivity of testing CPT symmetry in posit ronium decays with the Modular J-PET detector DTSTART;VALUE=DATE-TIME:20220712T090300Z DTEND;VALUE=DATE-TIME:20220712T090500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-777@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Neha Chug\; Jagiellonian University\, Poland ()\nAut hor: Neha Chug\n\nNeha Chug1\,2* on behalf of the J-PET Collaboration\n\n1 Faculty of Physics\, Astronomy and Applied Computer Science\, Jagiellonian University\, Krakow\, Poland\n2Center for Theranostics\, Jagiellonian Uni versity\, Krakow\, Poland\n*e-mail: neha.chug@doctoral.uj.edu.pl\n\nThe Ja giellonian Positron Emission Tomograph is the first plastic scintillator b ased tomographic device used to test discrete symmetries in the charged le ptonic sector [1]. One of such tests is for CPT symmetry\, under the combi ned transformation of charge\, parity and time reversal\, in the decays of positronium atoms [2]. J-PET performed its first measurement for CPT symm etry test by searching for non vanishing CPT-violating angular correlation s between the spin and orientation of decay plane of ortho-positronium (o- Ps) atoms\, which is the triplet state of positronium [3\, 4]. Sensitivity of testing CPT symmetry with the J-PET detector reaches the precision lev el of 10-4 [4]. Here we will discuss the prospects of improving the sensit ivity of this test beyond the level of 10-4 by enhancing the photon regist ration efficiency using a new layer of densely packed plastic scintillator s and a spherical annihilation chamber as a positronium production medium [5].\n\nAcknowledgement:\nThe authors acknowledge support by the TEAM POIR .04.04.00-00-4204/17 program\, the NCN grant no. 2019/35/B/ST2/03562 and 2 021/42/A/ST2/00423\, and the SciMat and qLife Priority Research Areas budg et under the program Excellence Initiative - Research University at the Ja giellonian University.\n\nReferences:\n[1] P. Moskal et. al.\, Acta Phys. Polon. B 47\, 509 (2016)\n[2] B. K. Arbic et al.\, Phys. Rev. A 37\, 3189 (1988)\n[3] A. Gajos et al.\, Acta. Phys. Pol. A 137\, 126 (2020).\n[4] P. Moskal\, A. Gajos et. al.\, Nature Communications\, 12\, 5658 (2021)\n[5] A. Gajos\, Symmetry\, 12(8)\, 1268 (2020)\n\nhttps://indico.koza.if.uj.ed u.pl/event/7/contributions/777/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/777/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Testing Quantum Foundations in the Cosmic Silence DTSTART;VALUE=DATE-TIME:20220712T120000Z DTEND;VALUE=DATE-TIME:20220712T122000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-670@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kristian Piscicchia\; Centro Ricerche Enrico Fermi - Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi"\, It aly ()\nThe VIP experiment\, operated at the Laboratori Nazionali del Gran Sasso (LNGS) of INFN\, aims to perform high sensitivity tests of the Paul i Exclusion Principle (PEP) for electrons. In the context of Local Quantum Field Theories\, deviations from PEP are strongly constrained by the Mess iah Greenberg Superselection (MGS) rule\, which forbids superpositions of states with different symmetry. Such models can then be only tested with o pen systems. Such a condition is fulfilled in VIP-2 by introducing new ele ctrons in a pre-existing system of electrons\, and testing the resulting s ymmetry state. An overview of the latest VIP-2 Open Systems result will be presented.\n\nPEP violations\, transgressing MGS\, were recently shown to be induced by space-time non-commutativity\, a class of universality for several models of Quantum Gravity. High sensitivity tests of PEP violation in closed systems represent the better candidates to test the non-commuta tivity emergence in Quantum Gravity\, at unexpectedly high energy scales. The results of exploratory studies will be shown.\n\nThe extremely low bac kground environment of LNGS is also suitable for investigating the measure ment conundrum\, one of the main mysteries of Quantum Mechanics Foundation s. Dynamical models of wave function collapse explain the quantum-to-class ical transition by a progressive reduction of the superposition\, proporti onal to the increase of the mass of the system. The results of our analyse s\, setting the strongest bounds on the collapse models\, will be presente d.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/670/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/670/ END:VEVENT BEGIN:VEVENT SUMMARY:CP Discrete Symmetry study in the decay of ortho-Positronium atom using the J-PET detector. DTSTART;VALUE=DATE-TIME:20220712T090100Z DTEND;VALUE=DATE-TIME:20220712T090300Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-778@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Kavya Valsan Eliyan\; Jagiellonian University\, Pola nd ()\nKavya Valsan Eliyan\, Juhi Raj\, On Behalf of the J-PET Collaborati on Jagiellonian University.\n\nFaculty of Physics\, Astronomy and Applied Computer Science\, Jagiellonian University\, Kraków\, Poland.\nTheranosti cs Center\, Jagiellonian University\, Kraków\, Poland.\nEmail: kavya.eliy an@doctoral.uj.edu.pl\, juhi.raj@doctoral.uj.edu.pl\n\nInteraction between electron-positron pair leads to direct annihilation into photons or creat ion of a bound state called Positronium. Positronium is the lightest purel y leptonic object decaying into photons [1-3]. Positronium atom can be for med in two states based on the spin alignment of its constituting particle s\, Singlet state (1S0 -para-Positronium (p-Ps) and Triplet state (3S1- or tho-Positronium (o-Ps). Constrained by conservation laws\, the o-Ps annihi late into odd number of photons (o-Ps → 3γ\, where γ = 1\, 2\, …)\, while the p-Ps decay into an even number of photons (p-Ps → 2γ\, where γ – 1\,2\, 3\, ...) [4\,5]. As an atom bound by a central potential\, i t is a parity eigenstate\, and as an atom built out of an electron and an anti-electron\, it is an eigenstate of the charge conjugation operator [1] . Therefore\, the positronium is a unique laboratory to study CP discrete symmetry involving correlations of photons momenta originating form o-Ps a nnihilation [6]. The Standard Model predicts that the photon–photon inte raction and weak interactions will mimic the symmetry violation in the ord er of 10−9 and 10−13 respectively [6]. Violation of CP invariance in p urely leptonic systems has never been seen so far [7]. The experimental li mits on CP and CPT symmetry violation in the decays of o-Ps are set at the level of 10−3 [2\,8].\n\nIn the year 2021\, the limitations of the prev ious experiments were overcome by the J-PET detector due to its much highe r granularity and improve the world result by a factor of three and reache s the statistical precision of 10−4. The reported result is the present best upper limit on the CP violation in the decay of ortho-Positronium\, l eaving us 5 orders of more statistical sensitivity to be explored in this aspect. J-PET detector is constructed of 192 polymer scintillators\, where each scintillator is attached with photomultipliers at each end. 192 scin tillators are arranged co-axially in three layers at 3 different radii 42. 5 cm\, 46.75 cm\, 57.5 cm respectively. Positronium atom can be formed in the center of J-PET detector using the beta-emitter 22Na source placed ins ide a small chamber. The source is sandwiched between an aerogel material. Plastic scintillators offer high time and angular resolution. Time Over T hreshold is adopted as a measure of energy deposition. The signals are mea sured by using the trigger-less data acquisition [9-12]. All of the previo us investigations with Positronium\, which tested the discrete symmetries\ , were based on symmetry odd operators constructed as the products of phot ons momenta (k⃗ i̇ ) and Positronium spin (S⃗ ̇ ) vectors [2-4\,6]. This project describes an extended study using another proposed operator [ 4]\, taking advantages of properties of the 3 layered J-PET detector\, whi ch enables to determine the linear polarization direction of annihilation photons. Measurement of polarization direction of annihilation photons (51 1 keV) is a unique feature of the J-PET detector which allows the study of CP symmetry violation by determining the expectation values of the CP sym metry odd operator (ε⃗ i⋅.k⃗ j) where i ≠j). As a future prospect \, the J-PET collaboration has developed a modular version of the J-PET de tector to improve the detection efficiency of this measurement and provide larger statistics in a shorter duration of measurement time to improve th e precision significantly.\n\nACKNOWLEDGEMENTS:\nThe author acknowledge su pport by the TEAM POIR.04.04.00-00-4204/17 program\, the NCN grant no. 202 1/42/A/ST2/00423 and the SciMat and qLife Priority Research Areas budget u nder the program Excellence Initiative - Research University at the Jagiel lonian University.\n\nReferences:\n[1] M. Skalsey\, J. Van House\, Phys. R ev. Lett. 67\, 1993 (1991).\n[2] P. A. Vetter\, S.J. Freedman\, Phys. Rev. Lett. 91\, 263401 (2003).\n[3] T. Yamazaki\, T. Namba\, S. Asai\, T. Koba yashi\, Phys. Rev. Lett. 104\, 083401 (2010).\n[4] P. Moskal et al.\, Acta Phys. Polon. B 47\, 509 (2016).\n[5] E.Czerwinski et al.\, Acta Phys. Pol on. B 48\, 509 (2017).\n[6] P. Moskal\, A. Gajos\, M. Mohammed\, Nat. Comm un. 12\, 5658 (2021).\n[7] V. A. Kostelecky and N. Russell\, 2018 update t o Rev. Mod. Phys. 83\, 11 (2011).\n[8] T. Yamazaki\, T. Namba\, S. Asai\, T. Kobayashi\, Phys. Rev. Lett. 104\, 083401 (2010).\n[9] M. Palka\, Jour. Of Instr. 12\, P08001 (2017)\n[10] G. Korcyl et al.\, Acta Phys. Polon. B 47\, 491 (2016).\n[11] Sz. Niedzwiecki et al.\, Acta Phys. Polon. B 48\, 1567 (2017).\n[12] A. Gajos et al.\, Nucl. Instr. and Meth. A 819\, 54 (20 16).\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/778/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/778/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: A bound diproton: is it “illusive” particle or e xotic nucleus? DTSTART;VALUE=DATE-TIME:20220712T122000Z DTEND;VALUE=DATE-TIME:20220712T124000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-671@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Ihor Kadenko\; International Nuclear Safety Center o f Taras Shevchenko National University of Kyiv\, Ukraine ()\nWe report on a search for a bound diproton\, or 2He nucleus\, by analyzing the results of irradiation of Tb and Ta samples with protons of 5.8 and 6.9 MeV energy \, correspondingly. These proton energies are about threshold energies for corresponding (p\,2p) nuclear reaction channel. The irradiated Tb and Ta samples were then counted with application of HPGe gamma-spectrometer. The peaks of 511 keV energy and of high intensities were detected in the inst rumental gamma-ray spectra. We measured its intensity vs time and derived the corresponding values for half-lives. These values are the following:\n - for Tb sample: 5\,603 ± 385 s after extended cooling of irradiated\nsam ple\;\n- for Ta sample: 1\,224 ± 56 s and 6\,307 ± 340 s.\nIn order to a ssign these half-lives to any reaction products on (p\,x) nuclear reaction s on Ta and Tb as well as impurities in these samples\, we could not ident ify any significant contributors to the 511 keV peak intensity of certain half-lives.\nThen we make an assumption about the formation of the diproto n\, or 2He bound and proton-excess nucleus\, to be a source of positrons w ith subsequent annihilation of them in a sample volume. The idea for the d iproton to exist is based on the prediction of A. Migdal in 1973 for two i dentical particles to become bound in the potential well of a heavy nucleu s but outside of its volume. This prediction was experimentally proved by us for two neutrons\, bound together in one nucleus – the dineutron and does not exclude the existence of a similar bound system\, but comprised o f two protons.\nIn the same time\, theoretical estimates for a positron de cay mode of the diproton were obtained as follows:\n- for a diproton decay into a triplet deuteron state: 1140 ± 216 s\;\n- for a diproton decay in to a singlet deuteron state: 5516 ± 1031 s.\nPossible algorithms to calcu late diproton binding energy and radius as well as mutual space arrangemen ts between a heavy nucleus and the diproton are also considered.\nBased on our preliminary results and estimates one can assume that such an approac h to generate and study diprotons in detail may result in discovery of the very unusual system “the heavy nucleus-diproton” to confirm for the d iproton the status of being the unique nucleus rather than an “illusive ” particle.\nIn addition\, the existence of such out-and-outer 2He nucle us may have far-reaching consequences on our understanding of nucleon-nucl eon and nucleon-nucleus interactions as well as practical app\n\nhttps://i ndico.koza.if.uj.edu.pl/event/7/contributions/671/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/671/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Search for η’-mesic nuclei in (p\,dp) reaction at GSI/FAIR DTSTART;VALUE=DATE-TIME:20220712T124000Z DTEND;VALUE=DATE-TIME:20220712T130000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-672@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Yoshiki Tanaka\; RIKEN\, Japan ()\nPossible existenc e of η′ meson nucleus bound states (η′-mesic nuclei) has been attrac ting both theoretical and experimental interests due to their relation to axial U(1) anomaly and chiral symmetry breaking in QCD. Experiments to sea rch for η′-mesic nuclei were recently performed by using the (p\,d) rea ction at GSI and by the (γ\, p) reaction at SPring-8. However\, no signif icant peak structure of the bound mesic states was so far observed\, which lead to upper limits of the formation cross sections as well as constrain ts on the η′-nucleus potential. In order to further investigate η′-m esic nuclei\, new experiments with an increased experimental sensitivity a re necessary.\n\nAt GSI/FAIR\, we have performed a new experiment in 2022 by combining the large-acceptance detector system WASA with the forward hi gh-resolution spectrometer FRS to search for η′-mesic nuclei with an im proved sensitivity. We employed a 2.5 GeV proton beam from the SIS-18 sync hrotron and used the FRS for high-resolution missing-mass spectroscopy of the 12C(p\,d) reaction near the η′-meson production threshold. Simultan eously\, possible decay particles from the produced η′-mesic nuclei\, p articularly high-energy protons\, were detected and identified by the WASA detector system surrounding the reaction target to enhance the signal-to- background ratio of the missing-mass spectrum.\n\nIn this contribution\, w e will report on this recent experiment including the status of the data a nalysis.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/672/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/672/ END:VEVENT BEGIN:VEVENT SUMMARY:Polarisation observables Sigma\, T\, P and H in pi0 and eta photop roduction off quasifree nucleons DTSTART;VALUE=DATE-TIME:20220712T153000Z DTEND;VALUE=DATE-TIME:20220712T155000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-679@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Nicolas Jermann\; University of Basel\, Switzerland ()\nThe excitation spectrum of the nucleon is an important testing ground for quantum chromodynamics in the regime where it cannot be treated pertur batively. During the last two decades much progress has been made on the t heory side\, e.g. lattice gauge methods and in experiments\, particularly using energy tagged photon beams at electron accelerators\, which has now reached a state where not only differential cross sections but also asymme tries measured with polarised photons\nand polarised targets allow for det ailed partial wave analyses. This provides much more stringent information about the involved reaction multipoles and thus the contributing nucleon resonances. The present experiment was done at the ELSA accelerator in Bon n with the Crystal Ball/TAPS detector setup. The incident electron beam of 3.2 GeV impinged on a diamond radiator where it produced coherent bremsst rahlung photons with linear polarisation\, which again impinged\non a tran sversely polarised\, deuterated butanol target. This allows the simultaneo us measurement of the polarisation observables Σ\, T\, P and H. Analysed were the final states Nπ0 and Nη with the almost 4π covering electromag netic calorimeter Crystal Ball/TAPS.\nOne of the main motivations of this experiment was a more detailed investigation of the not yet understood nar row structure in the excitation function of the γn→nη reaction at appr oximately 1 GeV.\nPreliminary results will be discussed.\n\nhttps://indico .koza.if.uj.edu.pl/event/7/contributions/679/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/679/ END:VEVENT BEGIN:VEVENT SUMMARY:Helicity dependent cross sections for the photoproduction of π0π ± pairs from quasi-free nucleons DTSTART;VALUE=DATE-TIME:20220712T155000Z DTEND;VALUE=DATE-TIME:20220712T161000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-680@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Debdeep Ghosal\; University of Basel\, Switzerland ( )\nPhoton induced π0π±-pairs production from quasi-free nucleons bound in the deuteron has been investigated in view of the helicity dependence o f those two reactions. Measurements with a liquid deuterium target were us ed to extract the unpolarized cross sections for protons and neutrons. A d euterated\, longitudinally polarized butanol target together with a circul arly polarized photon beam was also used to measure the double polarizatio n observable E. Antiparallel and parallel spin configurations of the beam photon and target nucleon correspond to the spin-dependent cross sections σ1/2 and σ3/2 respectively\, which have been derived from E. The measure ments were done at the Mainz MAMI accelerator with tagged photon beams pro duced via bremsstrahlung from longitudinally polarized electron beams. The reaction products from the two target types were detected with an almost 4π solid-angle covering calorimeter composed of the Crystal Ball\, TAPS d etectors and particle identification detectors. The results are sensitive to sequential decays of nucleon resonances via intermediate states and als o by emission of charged ρ mesons. Furthermore\, the results have been co mpared to the recent available model calculation.\n\nhttps://indico.koza.i f.uj.edu.pl/event/7/contributions/680/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/680/ END:VEVENT BEGIN:VEVENT SUMMARY:Mirror Matter searches with the J-PET detector DTSTART;VALUE=DATE-TIME:20220714T071500Z DTEND;VALUE=DATE-TIME:20220714T073500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-696@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Elena Perez del Rio\; Jagiellonian University\, Pola nd ()\nThe Positronium system\, a bound state of an electron and a positro n\, is suitable for testing the predictions of quantum electrodynamics (QE D)\, since its properties can be perturbatively calculated to high accurac y and\, unlike the hydrogen system\, is not affected by finite size or QCD effects at the current experimental precision level. Experiments searchin g for invisible decays of the Ps triplet state\, the ortho-Positronium (o- Ps)\, which mainly decays to three photons\, are being conducted\, since t hey are sensitive to new physics scenarios\, e.g. mirror matter\, milli-ch arged particles\, and extra space-time dimensions.\n\nThe particular case of Mirror Matter (MM) and its search with the J-PET setup is presented in this talk.\nMirror Matter was originally proposed to restore parity violat ion in weak interactions\, by introducing a new hidden mirror sector where parity is violated in the opposite way. This means that under certain spa tial inversion the particles transform into a parity reflected new mirror state. These mirror partners would interact with Standard Model (SM) parti cles via gravitation\, making them suitable candidates for Dark Matter. In the o-Ps system\, the photons from the decay would oscillate into their m irror partners\, leaving no signal in the detector. By performing a high p recision measurement of the o-Ps lifetime\, the accuracy of the present QE D calculations can be tested and a search for the invisible decays of the o-Ps conducted. A discrepancy with the expectation from theory could indic ate the presence of Physics Beyond the SM\, i.e. a signal for MM.\n\nThe p resented search is conducted with the novel total-body Positron-Electron T omography (PET) scanner at the Jagiellonian University. The J-PET is a lar ge and high precise medical imaging tool\, based on plastic scintillators. \n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/696/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/696/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Perspectives of preclinical research in Bialystok Ce nter of Molecular Imaging DTSTART;VALUE=DATE-TIME:20220715T092500Z DTEND;VALUE=DATE-TIME:20220715T094500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-716@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Anna Gromotowicz-Poplawska\; Medical University of B ialystok\, Poland ()\nBialystok Center of Molecular Imaging (BCMI) is one of the key elements of the new project of the Innovative Research Center f or the Prevention of Civilization Diseases and Individualized Medicine (CB I PLUS)\, that is now proceeding by the Medical University of Bialystok (M UB). This will be the first laboratory for the synthesis and quality contr ol of radiopharmaceuticals in the region and the first PET/MR preclinical research center in Poland. The main goal of BCMI is to develop new radioph armaceuticals for the early diagnosis and treatment of civilization diseas es. This will be supported by the preclinical and clinical research with t he innovative molecular imaging technique application. The BCMI labs will follow the GMP and GLP procedures. At the moment\, the construction of the BCMI is underway. The GMP documentation has already been prepared and the purchase of the hot cell\, synthesis unit\, 68Ge/68Ga generator and quali ty control system is ongoing. In the preclinical research labs the PET/MR and SPECT/CT scanners for small animals will be installed. The configurati on of systems will allow for a whole body scan\, brain\, heart\, lung and amdominal imaging in preclinical research in the field of oncology\, neuro logy\, cardiology and metabolic diseases. The animal scanners will be a pa rt of the unique imaging system that is already used in the MUB (i.a. huma n PET/MR hybrid system)\, thus providing the translational research. BCMI will increase opportunities for collaboration and conducting multicentre r esearch as well as international projects. The entire BCMI installation sh ould be completed in mid-2023.\n\nhttps://indico.koza.if.uj.edu.pl/event/7 /contributions/716/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/716/ END:VEVENT BEGIN:VEVENT SUMMARY:Polymer and composite carriers for controlled drug release DTSTART;VALUE=DATE-TIME:20220714T130500Z DTEND;VALUE=DATE-TIME:20220714T132500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-719@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Marek Gorgol\; Maria Curie-Sklodowska University\, P oland ()\nDelivering of the active pharmaceutical ingredients (APIs) to th e organism in the desired manner is a great challenge. Therefore\, it is i mportant to develop and investigate new systems\, allowing to control both the rate and the period of drug delivery. In such systems\, the carrier\, in which API is dissolved\, can and should be designed and/or modified in a way which allows to control the infiltration of the dissolution medium into the system\, resulting in a modification of API release. The porous m atrices seem to be suitable carriers for this purpose\, as a solid dispers ion of the drug can be formed inside of them.\nSeveral solid API dispersio ns have been developed with diclofenac sodium as API and porous carriers s uch as mesoporous polymers: poly(trimethylolpropane trimethacrylate) (poly (TRIM))\, and commercially available Amberlite® XAD7HP as well as polymer -silica composites [1]. Additionally\, selected carriers were modified by functionalizing with 3-aminopropyl groups or tableting by mechanical compr ession.\nThe rate of the diclofenac sodium release from each of solid disp ersions was examined in vitro to assess their usefulness for the controlle d release. The use of XAD7HP with small amount of API and poly(TRIM) funct ionalized with 3-aminopropyl groups as porous carriers gave satisfying res ults\, with the drug release profile quite close to linear\, Unfortunately \, good release profiles were obtained at the expense of reducing the amou nt of released API from nearly 100% to about 50% after 24 hours. It is als o worth to mention\, that increasing the amount of diclofenac sodium added into XAD7HP caused nonhomogeneous distribution of API inside a carrier an d gave non-satisfying results in the release profile.\nTo better understan d the course of the drug release\, the initial distribution of diclofenac sodium within the carrier for each solid dispersions as well as the distri bution of remaining diclofenac sodium after various release times for sele cted samples were studied. The morphology and the spatial distribution of the elements in sample cross-sections were determined with scanning electr on microscopy (SEM) coupled with energy dispersive spectroscopy (EDS). The porosity of the investigated systems was characterized with classic low-t emperature N2 adsorption porosimetry and positron porosimetry based on pos itron annihilation lifetime spectroscopy (PALS).\n\n[1] A. Kierys\, R. Zal eski\, M. Grochowicz\, M. Gorgol and A. Sienkiewicz\, Micropor Mesopor Mat \, 294\, 109881 (2020).\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contri butions/719/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/719/ END:VEVENT BEGIN:VEVENT SUMMARY:Key talk: Idea of theranostics in nuclear medicine. Where we are? DTSTART;VALUE=DATE-TIME:20220711T081000Z DTEND;VALUE=DATE-TIME:20220711T083500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-579@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Leszek Krolicki\; Medical University of Warsaw\, Pol and ()\nTheranostics is a relatively new field of medicine\, although its roots go back at least 70 years. This principle implies that treatment sho uld be based on well-defined medical/biological goals defined by imaging m ethods.\nOver the last decade\, there has been rapid progress in this area . In recent years\, the number of publications on theranostic techniques h as reached around 1\,000/year. Theranostics covers various areas: radioiso tope-based therapy\, bioimage guided radiotherapy\, optical imaging\, lase r ablation and surgery or nanotherapy.\n• Radiotheranostics is perhaps t he most advanced clinical application of theranostics\, with many advances and emerging opportunities. In these procedures\, indications for radiois otope therapy are based directly on the results of scintigraphic images: s cintigraphy indicates whether a given radiopharmaceutical accumulates in t he appropriate amount in the tumor\; a therapeutic radiopharmaceutical is used only when the scintigraphy indicates a sufficiently large accumulatio n of the diagnostic form of the radiopharmaceutical. Therefore\, pairs of radioisotopes are sought - emitting gamma radiation (for diagnostics) and emitting beta or alpha radiation (for therapeutic purposes). Examples incl ude 123I (for diagnosis) and 131I (for treatment) in malignant or benign t hyroid diseases. The second direction of the development of radiotheranost ics is the use of known theranostic radiopharmaceuticals in the diagnosis and treatment of other diseases. An example is the use of somatostatin ana logues labelled with 177Lu in the treatment of pheochromocytoma\, breast c ancer\, small-cell lung cancer or meningioma. 177Lu labelled PSMA is adapt ed for treatment of thyroid\, hepatocellular or renal cancer. The examinat ions are conducted on the use of various radioisotopes depending on the ty pe and severity of the disease. The search for new therapeutic targets is also underway. The current results indicate that new therapeutic targets m ay turn out to be CXCR-4\, FAPI\, gastrin-releasing peptide receptor\, int egrin αVβ3 or αVβ5 receptors\, CD38\, CD45.\nThe next direction in the development of theranostics is the use of tandem therapies. The combinati on of radioisotope treatment and chemo-/immunotherapy seems to be more eff ective. An important achievement in recent years is also the possibility o f characterizing the tumor microenvironment: activity of immune cells and fibroblasts\, extracellular matrix or angiogenesis. This information is he lpful (or even critical) in selecting the appropriate treatment for patien ts.\nToday\, radiotheranostics constitutes a new view on therapeutic proce dures\, and nuclear medicine is currently the best tool for its developmen t.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/579/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/579/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: A statistical reconstruction algorithm for positroni um lifetime imaging using time-of-flight positron emission tomography DTSTART;VALUE=DATE-TIME:20220711T122000Z DTEND;VALUE=DATE-TIME:20220711T124000Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-658@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Hsin-Hsiung Bill Huang\; University of Central Flor ida\, USA ()\nAs an emerging technology\, positronium lifetime imaging (PL I) using time-of-flight (TOF) positron emission tomography (PET) provides supplemental information reflecting the microenvironment surrounding the t issue\, in addition to the radiotracer activities from PET scan. However\, due to the finite coincidence resolving time (CRT)\, typically on the ord er of 200 – 600 ps\, reconstruction of the lifetime image from PLI list- mode events has yet to be fully developed. \n Previous studies have estab lished the feasibility of positronium lifetime imaging using TOF PET scann ers that have superior CRT to allow precise localization of each event in space [Moskal 2019\, Shibuya 2020]. Currently\, no practical TOF PET scann ers have the needed CRT and therefore the studies consider only well-separ ated sources that can be resolved by systems having a finite CRT. The exis ting positronium imaging method [Qi 2022] considers the marginal likelihoo d of the lifetime parameter given the radiotracer activity parameter and a pplies a surrogate function to estimate the lifetime parameter. In contras t\, our proposed method directly models the lifetime and activity paramete rs and estimates them jointly. Our method overcomes all these challenges a nd produces quantitatively correct lifetime images beyond the resolution l imit of the system CRT.\n We address the problem of reconstructing the li fetime image from TOF PET data with finite CRT. We present a statistical r econstruction framework that maximizes the likelihood of observed PLI even ts\, each comprising the following observable attributes: the detector re ceiving the prompt gamma\, the detector pair receiving the annihilation pa ir\, the time difference between the detection of prompt gamma and annihil ation pair\, and the time difference between the two photons within the an nihilation. In our study\, our simulation data include the flight time of the photons before detection and our method does not require having sub-1 00 ps TOF resolution for accurate localization of each detected event. We have verified our method using PLI events generated by the Monte-Carlo si mulation.\n\nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/658/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/658/ END:VEVENT BEGIN:VEVENT SUMMARY:Invited talk: Towards High Sensitivity and High-Resolution PET Sca nners\; Image-guided Proton Therapy and Total Body imaging DTSTART;VALUE=DATE-TIME:20220713T140500Z DTEND;VALUE=DATE-TIME:20220713T142500Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-729@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Karol Lang\; University of Texas at Austin\, USA ()\ nhttps://indico.koza.if.uj.edu.pl/event/7/contributions/729/ LOCATION:Collegium Novodvorscianum URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/729/ END:VEVENT BEGIN:VEVENT SUMMARY:Monte Carlo simulation platform and software stack in Dose-3D proj ect DTSTART;VALUE=DATE-TIME:20220712T081900Z DTEND;VALUE=DATE-TIME:20220712T082100Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-735@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jakub Hajduga\; AGH University of Science and Techno logy WFIIS\, Poland ()\nAuthors: Jakub Hajduga\, Dose-3D Collaboration\n\n As part of the Dose-3D project titled "Reconfigurable detector for measuri ng spatial distribution of radiation dose for applications in preparing in dividual patient treatment plans"\, in addition to the construction of the new type of phantom itself\, it is necessary to develop high-end software for dose simulation\, configuration and control of the entire device and finally the data analysis. Within the project comprehensiveness the softwa re stack comprises a number of packages for data processing and analysis ( Monte Carlo generators\, Raw data preprocessing\, Machine Learning tools\, Python/C++ modules\, Medical Physics specific software for DICOM standard ).\nThe Monte Carlo simulation itself is an essential element for the succ ess of the Dose-3D project. This is related to the fact that MC physics si mulations are the gold standard cross-check for planning and cross validat ion of experimental data. Using a framework based on the Geant4 engine we will produce data that mimics real apparatus. The data will be used to opt imize the parameters of the Dose-3D cell and ensure proper calibration of the prototype phantom.\nOne of the most important features of the final si mulation platform is the possibility to read-in and setup within simulatio n environment irradiation plans stored in DICOM-RT format.\nOne of the mos t important parts of the Dose-3D software stact is the middleware that bri dges gaps between the low and high level data processing. Based on the Pyt hon-like packages (with specific c++ modules binded to Python) we provide unified services to users. The presented work embraces a modern approach o f software engineering for the interdisciplinary scientific project which is the Dose-3D.\nThe aforementioned middleware in-house software is being developed as Python package called pydose3d. Its modules are responsible f or such functionalities as handling data from different sources (internal MC simulation based on Geant4\, PRIMO simulation and phantom measurements) \, where these data are then unified in a high-level data exchange format (Pandas Data Frame)\, modules responsible for basic visualization and anal ysis of acquired data\, or a set of tools responsible for loading informat ion about the planned course of radiotherapy from DICOM-RT files\, which c an then be loaded into the simulation itself.\n\nhttps://indico.koza.if.uj .edu.pl/event/7/contributions/735/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/735/ END:VEVENT BEGIN:VEVENT SUMMARY:Silicon as a candidate for a proton beam-activated tracer for rang e verification in proton therapy DTSTART;VALUE=DATE-TIME:20220712T082700Z DTEND;VALUE=DATE-TIME:20220712T082900Z DTSTAMP;VALUE=DATE-TIME:20260510T151142Z UID:indico-contribution-7-739@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Barbara Kołodziej\; Jagiellonian University\, Polan d ()\nAuthor: Barbara Kołodziej\nCo-authors: Aleksandra Wrońska\, Aleksa ndra Kaszlikowska\, Mareike Profe\, Ronja Hetzel \, Barbara Beus\, Magdale na Garbacz\, Renata Kopeć\n\nProton therapy is a radiotherapy method whic h is superior to conventional radiotherapy performed with photons because of the achievable dose conformality. However\, to fully benefit from the f avorable dose-depth profile of the ion beams\, new methods are required to monitor the treatment process online. A class of methods is under develop ment based on the analysis of prompt gamma radiation\, which can provide i nformation on the dose distribution in real time [1]. The idea of a proton beam-activated tracer\, discussed in this poster\, is based on detecting a prompt gamma signal from an element delivered to the tumor selectively a nd excited by the proton beam [2]. In the poster\, silicon will be present ed as a suitable candidate for such a tracer.\n\nInvestigation on silicon was performed using Geant4 simulations. The aim of the simulations was to obtain a prompt gamma spectrum and the response of a detector. In the simu lations\, a cuboid PMMA phantom was used as the target\, housing in its ce nter a silicone-doped insert (mass concentration of 2%). The phantom was i rradiated using a treatment plan layer by layer\, and the results were adj usted to include the anticipated acceptance of a detector. The use of an H PGe detector of RWTH Aachen [3]\, equipped with an active Compton shield\, was considered. Its response and effect on the registered spectrum were a lso investigated.\n\nFor proximal monoenergetic layers\, the signal from t he tracer was statistically significant when the Bragg peak was completely located in the insert. For distal layers\, when Bragg peak was outside th e insert\, the signal dropped noticeably\, but it was still visible becaus e the cross section for producing gamma particles is non-zero for higher-e nergy protons. Inclusion of the detector response did not change this obse rvation. However\, reduction of statistics resulting from detection effici ency lead to the necessity of including the active Compton shield in the d etection setup\, otherwise the signal was buried by background.\n\nThe res ults showed a dependence between the signal from silicon and the Bragg pea k position\, and this observation can be used to develop monitoring method s based on tracers activated by the proton beam. The next planned step is to confirm this result by experiment\, whose pilot run took place in Febru ary 2022 at the Cyclotron Centre Bronowice. This research was funded by th e Priority Research Area Digiworld under the program Excellence Initiative – Research University at the Jagiellonian University in Kraków and by the Polish National Agency for Academic Exchange.\n\nReferences:\n\nA. Wro ńska i D. Dauvergne. Range verification by means of prompt-gamma detectio n in particle therapy. W: Radiation Detection Systems\, tom 2. CRC Press/R outledge\, 2021. https://doi.org/10.1201/9781003218364-6\nhttps://agenda.i nfn.it/event/23656/contributions/120652/\nLaurent Kelleter et al\, Spectro scopic study of prompt-gamma emission for range verification in proton the rapy\, Physica Medica\, Volume 34\, 2017\, Pages 7-17\, ISSN 1120-1797\, h ttps://doi.org/10.1016/j.ejmp.2017.01.003\n\nhttps://indico.koza.if.uj.edu .pl/event/7/contributions/739/ LOCATION:Collegium Maius URL:https://indico.koza.if.uj.edu.pl/event/7/contributions/739/ END:VEVENT END:VCALENDAR