BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CERN//INDICO//EN BEGIN:VEVENT SUMMARY:Metabolic and positronium imaging sensitivity of the total body J- PET tomographs DTSTART;VALUE=DATE-TIME:20211010T100000Z DTEND;VALUE=DATE-TIME:20211010T102000Z DTSTAMP;VALUE=DATE-TIME:20260815T043008Z UID:indico-contribution-17-278@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Szymon Parzych (Faculty of Physics\, Astronomy and A pplied Computer Science Jagiellonian University\, 30-348 Kraków\, Poland) \nOn behalf of the J-PET Collaboration\n\nA new and popular trend in the f ield of medical imaging\, especially in the positron emission tomography\, is the construction of scanners with a whole human body coverage. Such to tal body PET tomographs prove to be much more efficient and accurate with respect to the clinically available PET systems [1]. One of the groups\, w hich is currently developing a total body scanner\, is the Jagiellonian PE T Collaboration (J-PET) [2]. In contrast to the standard crystal-based det ectors\, it utilizes axially arranged plastic scintillators.\n\nDuring con ventional PET imaging the information taken into reconstruction comes from the two\, back-to-back annihilation photons. Standard metabolic imaging e nables the diagnosis of the uptake of radiopharmaceuticals in cells [3]. N evertheless\, in almost 40% of cases positrons annihilations occur through the creation of a metastable positronium atom. Properties of such atoms l ike formation probability and mean lifetime turn out to have a dependence on the inner structure of tissues. It was proven that they can be used as an additional diagnostic indicator. The recently proposed positronium mean lifetime imaging method enables study of these characteristics [3-7]. \n\ nIn the framework of this work a simulation-based study of the sensitivity to the conventional and positronium imaging was conducted on the total bo dy tomographs designed with the J-PET technology. For that a dedicated Toy Monte-Carlo model working in the event-by-event basis has been developed and validated. The research was conducted basing on the “NEMA Standards Publication NU 2-2018” [8]. Moreover\, a comparison with the traditional short axial field of view PET system was performed.\n\nReferences:\n[1] S . R. Cherry et al.\, Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care\, J. Nucl. Med.\, vol . 59\, no. 1\, pp. 3-12\, Jan 2018\n[2] P. Moskal et al.\, Simulating NEMA characteristics of the modular total-body J-PET scanner – an economic t otal-body PET from plastic scintillators\, Phys Med Biol.\, vol. 66\, no. 17\, Sept 2021\n[3] P. Moskal\, E. Ł. Stepien\, Prospects and Clinical Pe rspectives of Total-Body PET Imaging Using Plastic Scintillators\, PET Cli n.\, vol. 15\, no. 4\, pp. 439-452\, Oct 2020\n[4] P. Moskal\, Positronium Imaging\, 2019 IEEE Nuclear Science Symposium and Medical Imaging Confere nce (NSS/MIC)\, 2019\, pp. 1-3\n[5] P. Moskal et al.\, Performance assessm ent of the 2 γpositronium imaging with the total-body PET scanners\, EJNM MI Phys.\, 7:44\, June 2020\n[6] P. Moskal et al.\, Positronium in medicin e and biology\, Nat Rev Phys\, vol. 1\, pp. 527–529\, Sept 2019\n[7] P. Moskal et al.\, Feasibility study of the positronium imaging with the J-PE T tomograph\, Phys Med Biol.\, vol. 64\, no. 5\, Mar 2019\n[8] NEMA Standa rds Publication NU 2-2018\, National Electrical Manufacturers Association\ , 2018\n\nhttps://indico.koza.if.uj.edu.pl/event/4/contributions/278/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/278/ END:VEVENT BEGIN:VEVENT SUMMARY:Innovative Positron Emission Tomography for a Beam Range Monitorin g in Proton Radiotherapy DTSTART;VALUE=DATE-TIME:20211010T090000Z DTEND;VALUE=DATE-TIME:20211010T092000Z DTSTAMP;VALUE=DATE-TIME:20260815T043008Z UID:indico-contribution-17-266@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Jakub Baran (IFJ PAN)\nImproving the precision and c onformity of proton treatment delivery by application of proton beam range monitoring remains to be one of the greatest challenges of the proton rad iation therapy[1]. One of the most commonly investigated approaches is to measure proton beam range by means of detection of annihilation gammas pro duced in patient during irradiation. A new\, modular\, easy-configurable p lastic scintillator based J-PET technology[2\,3] is being developed at the Jagiellonian University\, Poland offering the possibility to address the proton beam range monitoring by means of positon emission tomography (PET) imaging[4]. \n\nWe developed a workflow to perform Monte Carlo simulation s (GATE)[5] of proton therapy treatment of patients including β+ activity production\, coincidence events detection and PET image reconstruction (C ASToR)[6] just after the irradiation. Six different J-PET based scanner se tup configurations (single-layer\, multi-layer\, cylindrical\, dual-head) were designed and investigated. We compared efficiency\, number of registe red coincidences (true and scattered) and reconstructed activity images di stribution for different geometrical setup configurations. The expected ac tivity reconstructed using J-PET scanner was compared to the actual β+ ac tivity distribution produced in the patient. \n\nOur results show that all investigated J-PET setup configurations are feasible to acquire and recon struct the β+ activity produced during patient irradiation with a proton beam. The efficiency of the configurations ranges from 0.06% (single layer dual-head) to 0.52% (triple layer barrel). The reconstructed PET images w ere compared to ground truth production activity distribution revealing go od agreement\, which will be further improved by optimization of the recon struction and image post-processing protocols. Experimental validation of the simulations will be performed on phantoms and in the clinical-like con ditions in order to fully evaluate the J-PET detector capabilities.\n\n[1] Knopf\, AC\, and Lomax\, A.\, "In vivo proton range verification: a revie w." Physics in Medicine & Biology 58.15 (2013): R131.\n[2] Moskal\, P.\, e t al. "Positronium in medicine and biology." Nature Reviews Physics 1.9 (2 019): 527-529.\n[3] Moskal\, P.\, et al. "Simulating NEMA characteristics of the modular total-body J-PET scanner—an economic total-body PET from plastic scintillators." Physics in Medicine & Biology 66.17 (2021): 175015 .\n[4] Baran\, J.\, et al. "Studies of J-PET detector to monitor range unc ertainty in proton therapy." 2019 IEEE Nuclear Science Symposium and Medic al Imaging Conference (NSS/MIC). IEEE.\n[5] Grevillot\, L.\, et al. "GATE ‐RTion: a GATE/Geant4 release for clinical applications in scanned ion b eam therapy." Medical Physics 47.8 (2020): 3675-3681.\n[6] Merlin\, T.\, e t al. "CASToR: a generic data organization and processing code framework f or multi-modal and multi-dimensional tomographic reconstruction." Physics in Medicine & Biology 63.18 (2018): 185005.\n\nhttps://indico.koza.if.uj.e du.pl/event/4/contributions/266/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/266/ END:VEVENT BEGIN:VEVENT SUMMARY:3D printed lightweight and modular lithium-ion Uninterruptible Pow er Booster for medical devices. DTSTART;VALUE=DATE-TIME:20211010T094000Z DTEND;VALUE=DATE-TIME:20211010T100000Z DTSTAMP;VALUE=DATE-TIME:20260815T043008Z UID:indico-contribution-17-255@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Gabriel Moskal (Department of Chemical Technology\, Faculty of Chemistry of the Jagiellonian University\, Kraków\, Poland\;To tal-Body Jagiellonian-PET Laboratory\, Jagiellonian University\, Kraków\, Poland )\nAdvanced devices for diagnostics and medical therapy require a constant and stable power source. The disadvantage of commonly used uninte rruptible power supply (UPS) is the heavy weight[1]\, centralization and t he need to use specially prepared rooms and dedicated electrical installat ions. The aim of the presented research is to prepare a safe\, economic an d modular Uninterruptible Power Booster (UPB). A UPB can increase the insu fficient power output of the mains supply\, guaranteeing power for the pre -planned time. Low price and modularity are possible due to the use of 3D printing and Li-ion cells\, which will allow the construction of UPB insta lled in the immediate vicinity of the protected device. Among available te chnologies of chemical energy storage\, Li-ion cells are characterized by high gravimetric and volumetric energy density[1]. Currently\, liquid elec trolytes(LE) are used in Li-ion cells\, which have good ionic conductivity \, but are flammable\, toxic and sensitive to lithium dendrite overgrowth\ , which may lead to an internal short circuit and damage to a given module . For safety reasons\, a much better solution than LE would be solid elect rolytes(SE)\, which would not be flammable and hazardous to the environmen t. Due to the fact that SE constitute a barrier to lithium dendrites\, the y can extend the working time of li-ion cells[2]. Currently\, there is no known material that would fit well as a SE for li-ion cells. There are sev eral materials under development\, but they are not ready for industrial a pplications[3\,4].This presentation concerns the research conducted on SE\ , synthesized with the use of cheap\, environmentally safe materials. For this purpose\, syntheses of materials based on silicon glass and polysacch arides were performed. Methods of syntheses and the results for measuring the ionic conductivity of the tested electrolytes and an example UPB for J -PET mobile tomograph will be presented[5\,6]. The use of this solution wi th stationary devices will allow to reduce electricity costs by loading th e energy storage using a less expensive night tariff\, and then using the collected energy during the day\, and also to install the device in a room without access to a UPS system.\n[1]S. Anuphappharadorn Et al.\, Energy P rocedia\,56(2014)352-358\n[2]J. Xie\, Y. Lu\, Nature Communications\,11(20 20)2499\n[3]F. Zheng Et al.\, Journal of Power Source\,389(2018)198-213 \n [4]A. Manthiram Et al.\, Nature Reviews Materials\,2(2017)16103\n[5]P. Mos kal\, E. Stępień\,PET Clinics\,15(2020)439-452\n[6]P. Moskal et al.\, Na ture Reviews Physics\,1(2019)527-529\n\nhttps://indico.koza.if.uj.edu.pl/e vent/4/contributions/255/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/255/ END:VEVENT BEGIN:VEVENT SUMMARY:103Pd/103mRh in-vivo generator for Auger electron targeted therapy DTSTART;VALUE=DATE-TIME:20211010T092000Z DTEND;VALUE=DATE-TIME:20211010T094000Z DTSTAMP;VALUE=DATE-TIME:20260815T043008Z UID:indico-contribution-17-242@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Nasrin Abbasi Gharibkandi ( Institute of Nuclear Che mistry and Technology)\nIn recent years the application of Auger emitters for cancer targeted therapy has got great attention. Current clinically us eful systemic radiation therapies are mainly based on β- radiation emitte rs. However\, the tissue range of low energy β- particles is about severa l hundred cells length that is not optimal for treatment of small-size tum ors [1]. Tissue range of α particles is only around several cells length (40 – 100 µm)\, what in combination with their high linear energy trans fer (LET≈100keV/µm) results in high radiocytotoxicity. However\, this t herapeutic approach cannot be used widely due to the low availability of α-emitters [2]. Auger electrons are similar to high-LET particles\, like α particles\, and can induce considerable cell damage. Furthermore\, comp ared to α and β- radiation\, Auger emitters remain of low toxicity whil e travelling in blood or bone marrow but become highly efficient when inco rporated into DNA of target cells. Hence\, Auger radiotherapy is considere d a promising field for targeting small tumors such as metastases [3]. Sin ce most of the energy released by Auger electrons is deposited in close pr oximity from the decay site\, the successful use of Auger emitters in ther apy requires their precise delivery to a sensitive organelles in the cells [4]. We propose new idea to deliver the Auger emitter 103mRh to the cell nucleus by using an in-vivo 103Pd/103mRh generator conjugate. Synthesized trastuzumab or inhibitor of PSMA radiobiocojugates labeled with 103Pd (t1/ 2 = 16.99 d) will transport the radionuclide to the cytoplasm in the perin uclear area. As a result of nuclear decay\, 103mRh (t1/2=56 min) will be r eleased and in the form of 103Rh_aq^(3+) will penetrate the nuclear membra ne and bind to the DNA inducing cytotoxic effect. In the first step\, we s ynthesized Au nanoparticles\, which were covered with a layer of metallic Pd. Next\, using PEG linker\, we attached monoclonal trastuzumab to the co re-shell nanoparticles. The preliminary studies of cytotoxicity of non-rad ioactive Au@Pd nanoparticles and Au@Pd-trastuzumab bioconjugates were perf ormed.\nReferences\n[1] Y.-m. Song\, X.-r. Zheng\, and X.-q. Yao\, "Study on the interactions of ruthenium (III)\, rhodium (III) and palladium (II) ions with DNA\," Transition metal chemistry\, vol. 31\, pp. 616-620\, 2006 .\n[2] C. Parker\, V. Lewington\, N. Shore\, C. Kratochwil\, M. Levy\, O. Lindén\, et al.\, "Targeted alpha therapy\, an emerging class of cancer a gents: a review\," JAMA oncology\, vol. 4\, pp. 1765-1772\, 2018.\n[3] A. I. Kassis\, "The amazing world of auger electrons\," International journal of radiation biology\, vol. 80\, pp. 789-803\, 2004.\n[4] S. Aghevlian\, A. J. Boyle\, and R. M. Reilly\, "Radioimmunotherapy of cancer with high l inear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons\," Advanced drug delivery reviews\, vol. 1 09\, pp. 102-118\, 2017.\n\nhttps://indico.koza.if.uj.edu.pl/event/4/contr ibutions/242/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/242/ END:VEVENT END:VCALENDAR