BEGIN:VCALENDAR VERSION:2.0 PRODID:-//CERN//INDICO//EN BEGIN:VEVENT SUMMARY:Polystyrene-based plastic scintillators for theranostics applicati ons DTSTART;VALUE=DATE-TIME:20211010T082000Z DTEND;VALUE=DATE-TIME:20211010T084000Z DTSTAMP;VALUE=DATE-TIME:20260812T030334Z UID:indico-contribution-16-287@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Łukasz Kapłon (Jagiellonian University)\nŁukasz K apłon on behalf of the J-PET Collaboration.\n\nPlastic scintillators are used in many applications connected with medical devices\, for example in time-of-flight positron emission tomography [1]\, long-axial field of view positron emission tomography scanners [2] and in plastic scintillation do simetry [3]. Scintillators absorb ionizing radiation and convert its energ y into visible light via fluorescence. Purpose of this research is to find optimal fluorescent dyes combination dissolved in polystyrene matrix. Pol ymer scintillators were synthesized from styrene monomer in bulk radical p olymerization [4].\n\nIn this research one the best fluorescent compound e mitting ultraviolet light is combined with a few fluorescent dyes shifting scintillators emission to blue and green light spectrum [5]. Emission max ima of manufactured polystyrene scintillators are close to maximum quantum efficiency of light detectors used in plastic scintillation detectors. Li ght output of scintillators as a measure of gamma radiation conversion int o blue and green light will be presented. High light output and matching e mission spectra of scintillator with quantum efficiency of light detector is needed to obtain good signal-to-noise ratio in scintillation detectors [6].\n\nGreen-emitting plastic scintillators have several advantages over blue-emitting scintillators in plastic scintillation dosimetry application . Firstly\, green light is less attenuated by polystyrene matrix and yello w compounds resulting from radiation damage. Secondly\, the longer the wav elength of scintillators light\, the smaller portion of Cerenkov light is emitted in this green bandwidth in plastic dosimeter and subtraction of th is stem signal is easier. Thirdly\, green light around 500 nm is the least attenuated in plastic optical fibers usually glued to plastic scintillato rs forming scintillation dosimeter.\n\nReferences\n[1] S. Niedźwiecki et al.\, Acta Phys. Pol. B\, 48 (2017) 1567-1576\n[2] P. Moskal\, E. Stępie ń\, PET Clin\, 15 (2020) 439-452\n[3] L. Beaulieu\, S. Beddar\, Phys. Med . Biol.\, 61 (2016) R305-R343\n[4] Ł. Kapłon et al.\, Bio-Algorithms and Med-Systems\, 10 (2014) 27-31\n[5] Ł. Kapłon\, Acta Phys. Pol. B\, 51 ( 2020) 225-230\n[6] A. Wieczorek et al.\, PLoS ONE\, 12 (2017) e0186728 1-1 6\n\nThis work was supported by grant for the early stage of research fina ncing from Centre for Technology Transfer CITTRU from the Jagiellonian Uni versity in 2021\; the National Science Centre of Poland through grant OPUS No. 2019/35/B/ST2/03562 and the Jagiellonian University under project No. CRP/0641.221.2020.\n\nhttps://indico.koza.if.uj.edu.pl/event/4/contributi ons/287/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/287/ END:VEVENT BEGIN:VEVENT SUMMARY:Positron annihilation as a process to observe of the pathogenic ti ssue modification. DTSTART;VALUE=DATE-TIME:20211010T070000Z DTEND;VALUE=DATE-TIME:20211010T072000Z DTSTAMP;VALUE=DATE-TIME:20260812T030334Z UID:indico-contribution-16-251@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Bożena Jasińska (Institute of Physics\, Maria Curi e Sklodowska University)\nTwo the most known techniques based on positron- electron annihilation are PET (Positron Emission Tomography) and PALS (Pos itron Annihilation Lifetime Spectroscopy). \nPET is a diagnostic method en abling imaging of the metabolism of chosen substances in the living organi sm. Metabolism rate depends on many factors\, one of them is cancer growth in some region of body.\nOther technique\, commonly used in material scie nces\, PALS\, allows following precisely kind of processes leading to pos itron annihilation\, including creation and decaying the positronium (boun d state of positron-electron) states. It is known that o-Ps lifetime value reflects size of the free spaces in which it is trapped. Then one can exp ect it can be used to investigate tissue modification during some kind of diseases. Additionally\, intensity of this component allows to follow char ge activity of some processes\, including cell apoptosis or radical creati on.\nPreliminary investigation performed on real healthy and altered human tissues using PALS clearly indicates that it is possible to distinguish b etween healthy and diseased tissues and between different kinds of lesions of the some organ using techniques based on positron annihilation. So\, i t is justified to include the new imaging method based on positronium prop erties in PET diagnosis.\n\nhttps://indico.koza.if.uj.edu.pl/event/4/contr ibutions/251/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/251/ END:VEVENT BEGIN:VEVENT SUMMARY:Test targets for J-PET experiments with medicine and physics DTSTART;VALUE=DATE-TIME:20211010T080000Z DTEND;VALUE=DATE-TIME:20211010T082000Z DTSTAMP;VALUE=DATE-TIME:20260812T030334Z UID:indico-contribution-16-276@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Marek Gorgol (Maria Curie-Sklodowska University\, In stitute of Physics\, Department of Material Physics\, Pl. M. Curie-Sklodow skiej 1\, 20-031 Lublin\, Poland)\nJ-PET\, as a total body PET device\, gi ves an opportunity to perform additional investigations in medicine\, that couldn’t be performed with the use of standard PET detectors. It can be also used as new research device for physics. However\, these both aspec ts are very challenging because many difficulties and artifacts that requi res explanation and overcoming. Therefore\, various chambers and targets n eed to be used at particular stages of testing and development. The overvi ew of chambers dedicated for J-PET will be presented with the emphasis of various problems encountered during the research\, as well as the solution of each one. The future plans for creating the chambers required for the further stages of research will be also discussed.\n\nhttps://indico.koza. if.uj.edu.pl/event/4/contributions/276/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/276/ END:VEVENT BEGIN:VEVENT SUMMARY:Solid-liquid structure model for Ps-based oncological nanodiagnost ics DTSTART;VALUE=DATE-TIME:20211010T072000Z DTEND;VALUE=DATE-TIME:20211010T074000Z DTSTAMP;VALUE=DATE-TIME:20260812T030334Z UID:indico-contribution-16-273@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Bożena Zgardzińska (Institute of Physics\, Maria C urie-Sklodowska University)\nSolid-liquid structure model for Ps-based onc ological nanodiagnostics\n\nB. Zgardzińska*\nfor the J-PET collaboration\ n\n*email: bozena.zgardzinska@mail.umcs.pl\n\nInstitute of Physics\, Maria Curie-Sklodowska University\, Pl. Marii Curie-Skłodowskiej 1\, 20-031 Lu blin\, Poland\n\n\nFor an aging society\, the socio-economic consequences of neoplastic diseases justify research towards developing effective oncol ogical diagnostics. An opportunity for the development of highly sensitive nanodiagnostics is the combination of two technique based on the same ann ihilation process\, the Positron Emission Tomography (PET) and the Positro n Annihilation Lifetime Spectroscopy (PALS). While the first imaging techn ique uses annihilation quanta\, the second has been used for decades to de termine the structure of materials at nanometer level and based on the hyd rogen-like unstable positronium atom (Ps=e^-+e^+).\n The biological materi al still belongs to the group of complex systems that have been poorly inv estigated using the PALS technique. Due to large morphological and physiol ogical diversity of tissue\, different origin of cells\, metabolism and fu nctionality\, there are a number of factors that affect and disrupt the pr ocess of Ps creation and annihilation. On the other hand\, the neoplastic processes lead to tissue dysfunction and are associated with changes in bo th the structure and metabolism of the tissues building the organ. \n As a simplification of complex biological system we proposed to adopt a solid- liquid structure model. As a consequence of such approach we could disting uish two types of volumes in which Ps annihilates: the nano-bubbles in the liquid phase of the sample (body fluid\, mainly water)\, and the nano-vol umes in rigid structure\, similar to the solid phase of the sample.\n The samples taken from healthy and neoplastic tissues of the human uterus and liver were investigated using PALS technique. The analysis was performed u sing the solid-liquid structure model. The INTI plot mapping was used to d etermine the type and degree of neoplastic lesions. The total water conten t (free and physiosorbed) of healthy and altered tissue was estimated. The possible influence of chemical composition (radicals and O2 concentration ) as well as the chemotherapy treatment was discussed. \n The observations and the above listed results may be used to develop additional functional ity of new generation PET scanners in the field of non-invasive diagnostic s accompanying imaging.\n\nhttps://indico.koza.if.uj.edu.pl/event/4/contri butions/273/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/273/ END:VEVENT BEGIN:VEVENT SUMMARY:X-ray detectors for exotic atoms and other types of applications DTSTART;VALUE=DATE-TIME:20211010T074000Z DTEND;VALUE=DATE-TIME:20211010T080000Z DTSTAMP;VALUE=DATE-TIME:20260812T030334Z UID:indico-contribution-16-268@indico.koza.if.uj.edu.pl DESCRIPTION:Speakers: Catalina Curceanu (lnf-infn)\nI shall discuss variou s X ray detector systems used in exotic atoms experiments\, starting with the Silicon Drift Detectors used in kaonic atoms measurements at Frascati within the SIDDHARTA-2 experiment. I shall then present the VOXES system\, based on HAPG crystals\, able to perform extreme precision X ray measurem ents. The VOXES system can be used both for fundamental science and for so cietal applications\; in this context I shall present some of this ongoing applications at LNF-INFN.\n\nhttps://indico.koza.if.uj.edu.pl/event/4/con tributions/268/ LOCATION:Theranostics Center / on-line URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/268/ END:VEVENT END:VCALENDAR