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SUMMARY:Micro-CT journey - from bones to personalized medicine
DTSTART;VALUE=DATE-TIME:20211011T074000Z
DTEND;VALUE=DATE-TIME:20211011T080000Z
DTSTAMP;VALUE=DATE-TIME:20261008T200903Z
UID:indico-contribution-264@indico.koza.if.uj.edu.pl
DESCRIPTION:Speakers: Bartosz Leszczyński (M. Smoluchowski Institute of P
 hysics\, Jagiellonian University)\nX-ray microtomography (micro-CT) is a w
 ell establised nondestructive 3D method for small sample internal structur
 e imaging. For over 20 years\, micro-CT is known as a golden standard in b
 one microarchitecture analysis\, as an alternative to histological section
 ing  method for preclinical research [1\, 2]. Micro-CT surpasses histologi
 cal analysis because it provides 3D information with several micron sampli
 ng.\n\nIn recent years\, micro-CT has been succesfully used in micro-angio
 graphy research. For this purpose it needs addition of contrast agents eit
 her by staining the sample for ex-vivo scanning or using perfusion in smal
 l animal in-vivo micro-CT [3\, 4]. Staining methods enhance imaging contra
 st globally by diffusion process in examined tissue\, particullary in area
 s with high affinity to a specific contrasting solutions. Recent research 
 proofs the potential of this metod in imaging of 3D cell cultures called s
 pheroids [5]. The injected contrast agent works more locally. It can enhan
 ce image contrast of blood vessels\, heart\, kidneys and urinary bladder.\
 n\nFrom the other hand micro-CT is an indispensable tool in material scien
 ce including drug design for a personalized medicine. This work shows how 
 micro-CT can help in design and quality control of individualy 3D printed 
 tablets [6\, 7]. \n\n\nReferences\n\n[1] Leszczyński\, et al. (2014). Thr
 ee dimensional visualisation and morphometry of bone samples studied in mi
 crocomputed tomography (micro-CT). Folia morphologica\, 73(4)\, 422–428.
  https://doi.org/10.5603/FM.2014.0064\n[2]Pilutin\, A.\, et al. (2021). Mo
 rphology and serum and bone tissue calcium and magnesium concentrations in
  the bones of male rats chronically treated with letrozole\, a nonsteroida
 l cytochrome P450 aromatase inhibitor. Connective tissue research\, 62(4)\
 , 454–463. https://doi.org/10.1080/03008207.2020.1771329\n[3]Leszczyńsk
 i\, et al.(2018). Visualization and Quantitative 3D Analysis of Intraocula
 r Melanoma and Its Vascularization in a Hamster Eye. International journal
  of molecular sciences\, 19(2)\, 332. https://doi.org/10.3390/ijms19020332
 \n[4] Tielemans\, B.\, et al. (2020). From Mouse to Man and Back: Closing 
 the Correlation Gap between Imaging and Histopathology for Lung Diseases. 
 Diagnostics\, 10(9)\, 636. https://doi.org/10.3390/diagnostics10090636\n[5
 ] Karimi\, H.\, et al.(2020). X-ray microtomography as a new approach for 
 imaging and analysis of tumor spheroids. Micron\, 137\, 102917. https://do
 i.org/10.1016/j.micron.2020.102917\n[6] Jamróz\, W.\, et al. (2020). Spee
 d it up\, slow it down…An issue of bicalutamide release from 3D printed 
 tablets. European journal of pharmaceutical sciences : official journal of
  the European Federation for Pharmaceutical Sciences\, 143\, 105169. https
 ://doi.org/10.1016/j.ejps.2019.105169\n[7] Jamróz W.\, et al.(2020). Mult
 ivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crysta
 l-Forming Drug-Itraconazole. Materials\, 13(21)\, 4961. https://doi.org/10
 .3390/ma13214961\n\nhttps://indico.koza.if.uj.edu.pl/event/4/contributions
 /264/
LOCATION:Theranostics Center / on-line
URL:https://indico.koza.if.uj.edu.pl/event/4/contributions/264/
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